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The use of mathematical modelling techniques in biomedical research is playing an increasingly important role in the understanding of the pathophysiology of disease processes. This includes not only understanding mechanisms of physiological processes, but also diagnosis and treatment. In addition, its introduction in the study of genomics and proteomics is ...
Tracer Kinetics in Biomedical Research: from Data to Model
The use of mathematical modelling techniques in biomedical research is playing an increasingly important role in the understanding of the pathophysiology of disease processes. This includes not only understanding mechanisms of physiological processes, but also diagnosis and treatment. In addition, its introduction in the study of genomics and proteomics is key in understanding the functional characteristics of gene expression and protein assembly and secretion. Finally, with the increasing complexity and associated cost of drug development, modelling techniques are being used to streamline the process. This book is designed to give the reader the mathematical and statistical information necessary to design tracer kinetic studies, to use non-compartmental methodologies and/or to develop multi-compartmental models to interpret the data. The book starts with a review of fundamentals of radioactive and stable isotope tracer kinetics and then proceeds with a description of the non-compartmental and multi-compartmental modelling methodologies to study systems in the steady state.; The focus is on understanding the basic assumptions inherent in the methodologies and the underlying mathematics and statistics, on discussing how to assess how good a model is and on giving some hints on how better to design kinetic studies, in order to increase the probability of a successful study and to ensure the maximal information content in the experimental data to be extracted. The book has a section on parameter estimation, fitting models to data, first in general terms and then specifically related to non-compartmental and compartmental models. This is written from a basic point of view, and is intended to remove the mystery from the black box of computer optimization software. Finally, a special application often found in tracer kinetic analysis, precursor-product relationships, is discussed. Throughout the book, the goal is to provide even the novice with sufficient background so that he/she can feel comfortable. A number of case studies, based upon real experimental data, are carried through the text. Other examples illustrate specific points. All data examples are provided on a floppy disk.
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This publication is the fourth major treatise on photochromism involving organic molecules and derived systems. The first such book was edited by G.H. Brown in the Weissberger series in 1971, the second was edited by H. Durr and H. Bouas-Laurent in the Elsevier series in 1990. A third book, edited ...
Organic Photochromic and Thermochromic Compounds: Volume 2: Physicochemical Studies, Biological Applications, and Thermochromism
This publication is the fourth major treatise on photochromism involving organic molecules and derived systems. The first such book was edited by G.H. Brown in the Weissberger series in 1971, the second was edited by H. Durr and H. Bouas-Laurent in the Elsevier series in 1990. A third book, edited by C.B. McArdle, should be added to the list, which focuses on the very important topic of the behavior of photochromic systems in polymer matrices.; This book is a result of the large increase in the number of publications and patents concerning photochromic compounds and their use in various applications, such as ophthalmic lenses and security printing, during the last 10 years. As a result of this increased interest, two successful International Symposia on Photochromism have been held: the first, ISOP93, in France on Embiez Island near Bandol (September 12-16, 1993) and the second, ISOP96, in the United States in Clearwater, Florida (September 8-12, 1996). The number of countries represented at each of these symposia (17 and 16, respectively) attests to the international scope of the photochromic research community. This global interest is also exemplified by the authors of the chapters within this book. The aim of the second volume of this new review is focused on the physico-chemical properties and photochromic behavior of the best-known systems, leading to new developments in the known photochromic series or the discovery of new families.; However, chapters are included on the most appropriate physico-chemical methods by which photochromic substances can be studied (spectrokinetic studies on photostationary states, Raman spectroscopy, EPR, chemical computations and molecular modeling, X-ray diffraction analysis). In addition, special topics such as interaction between photochromic compounds and polymer matrices, photodegradation mechanisms, and potential biological applications have been treated. The last chapter, on thermochromic materials, is included to emphasize the chemical similarities between photochromic and thermochromic materials.; In general, the literature cited within the chapters covers publications through 1995.
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The foundation for understanding the function and dynamics of biological systems is knowledge of their structure. Many experimental methodologies are used for determination of structure, each with special utilities. The volumes in this series on Biological Magnetic Resonance emphasize the methods that involve magnetic resonance. This volume seeks to provide ...
Biological Magnetic Resonance: Volume 19: Distance Measurements in Biological Systems by Epr: 19
The foundation for understanding the function and dynamics of biological systems is knowledge of their structure. Many experimental methodologies are used for determination of structure, each with special utilities. The volumes in this series on Biological Magnetic Resonance emphasize the methods that involve magnetic resonance. This volume seeks to provide a critical evaluation of EPR methods for determining the distances between two unpaired electrons. The editors invited the authors to make this a very practical book, with specific numerical examples of how experimental data are worked up to produce a distance estimate, and realistic assessments of uncertainties and of the range of applicability, along with examples of the power of the technique to answer biological problems.
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