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Silent Spring catalyzed an environmental movement in the 1960s and achieved a ban on DDT, but are the alternatives any less toxic? Rachel Carson's eloquent book Silent Spring stands as one of the most important books of the twentieth century and inspired important and long-lasting changes in environmental science and ...
Banned: A History of Pesticides and the Science of Toxicology
Silent Spring catalyzed an environmental movement in the 1960s and achieved a ban on DDT, but are the alternatives any less toxic? Rachel Carson's eloquent book Silent Spring stands as one of the most important books of the twentieth century and inspired important and long-lasting changes in environmental science and government policy. Frederick Rowe Davis thoughtfully sets Carson's study in the context of the twentieth century, reconsiders her achievement, and analyzes its legacy in light of toxic chemical use and regulation today. Davis examines the history of pesticide development alongside the evolution of the science of toxicology and tracks legislation governing exposure to chemicals across the twentieth century. He affirms the brilliance of Carson's careful scientific interpretations drawing on data from university and government toxicologists. Although Silent Spring instigated legislation that successfully terminated DDT use, other warnings were ignored. Ironically, we replaced one poison with even more toxic ones. Davis concludes that we urgently need new thinking about how we evaluate and regulate pesticides in accounting for their ecological and human toll.
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42.000000 USD
Hardback
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This new edition overviews drug transporters and presents the principles of drug transport and associated techniques, featuring new chapters on multidrug and toxin extrusion proteins, placental transport, in silico approaches in drug discovery, and regulatory guidance for drug transport studies in drug development. Describes drug transporter families, mechanisms, and clinical ...
Drug Transporters: Molecular Characterization and Role in Drug Disposition
This new edition overviews drug transporters and presents the principles of drug transport and associated techniques, featuring new chapters on multidrug and toxin extrusion proteins, placental transport, in silico approaches in drug discovery, and regulatory guidance for drug transport studies in drug development. Describes drug transporter families, mechanisms, and clinical implications along with experimental methods for studying and characterizing drug transporters Includes new chapters on multidrug and toxin extrusion proteins, placental transport and in silico approaches in drug discovery Has a new chapter covering regulatory guidance for the evaluation of drug transport in drug development with global criteria used for drug transporters in clinical trials Arranges material to go from fundamental mechanisms to clinical outcomes, making the book useful for novice and expert readers
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114.12 USD
Hardback
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Fresh fruit and vegetables have been identified as a significant source of pathogens and chemical contaminants. As a result, there has been a wealth of research on identifying and controlling hazards at all stages in the supply chain. Improving the safety of fresh fruit and vegetables reviews this research and ...
Improving the Safety of Fresh Fruit and Vegetables
Fresh fruit and vegetables have been identified as a significant source of pathogens and chemical contaminants. As a result, there has been a wealth of research on identifying and controlling hazards at all stages in the supply chain. Improving the safety of fresh fruit and vegetables reviews this research and its implications for food processors. Part one reviews the major hazards affecting fruit and vegetables such as pathogens and pesticide residues. Building on this foundation, Part two discusses ways of controlling these hazards through such techniques as HACCP and risk assessment. The final part of the book analyses the range of decontamination and preservation techniques available, from alternatives to hypochlorite washing systems and ozone decontamination to good practice in storage and transport. With its distinguished editor and international team of contributors, Improving the safety of fresh fruit and vegetables is a standard reference for all those involved in fruit and vegetable production and processing.
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346.500000 USD
Hardback
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A key resource for toxicologists across a broad spectrum of fields, this book offers a comprehensive analysis of molecular modelling approaches and strategies applied to risk assessment for pharmaceutical and environmental chemicals. Provides a perspective of what is currently achievable with computational toxicology and a view to future developments Helps ...
Computational Toxicology: Risk Assessment for Chemicals
A key resource for toxicologists across a broad spectrum of fields, this book offers a comprehensive analysis of molecular modelling approaches and strategies applied to risk assessment for pharmaceutical and environmental chemicals. Provides a perspective of what is currently achievable with computational toxicology and a view to future developments Helps readers overcome questions of data sources, curation, treatment, and how to model / interpret critical endpoints that support 21st century hazard assessment Assembles cutting-edge concepts and leading authors into a unique and powerful single-source reference Includes in-depth looks at QSAR models, physicochemical drug properties, structure-based drug targeting, chemical mixture assessments, and environmental modeling Features coverage about consumer product safety assessment and chemical defense along with chapters on open source toxicology and big data
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194.250000 USD
Hardback
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Advances in Molecular Toxicology features the latest advances in all of the subspecialties of the broad area of molecular toxicology. Toxicology is the study of poisons, and this series details the study of the molecular basis by which a vast array of agents encountered in the human environment and produced ...
Advances in Molecular Toxicology: Volume 8
Advances in Molecular Toxicology features the latest advances in all of the subspecialties of the broad area of molecular toxicology. Toxicology is the study of poisons, and this series details the study of the molecular basis by which a vast array of agents encountered in the human environment and produced by the human body itself manifest themselves as toxins. Not strictly limited to documenting these examples, the series is also concerned with the complex web of chemical and biological events that give rise to toxin-induced symptoms and disease. The new technologies that are being harnessed to analyze and understand these events will also be reviewed by leading workers in the field. Advances in Molecular Toxicology will report progress in all aspects of these rapidly evolving molecular aspects of toxicology with a view toward detailed elucidation of progress on the molecular level and on advances in technological approaches employed.
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303.12 USD
Hardback
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Specifically geared to personnel in the pharmaceutical and biotechnology industries, this book describes the basics and challenges of oral bioavailability one of the most significant hurdles in drug discovery and development. Describes approaches to assess pharmacokinetics and how drug efflux and uptake transporters impact oral bioavailability Helps readers reduce the ...
Oral Bioavailability Assessment: Basics and Strategies for Drug Discovery and Development
Specifically geared to personnel in the pharmaceutical and biotechnology industries, this book describes the basics and challenges of oral bioavailability one of the most significant hurdles in drug discovery and development. Describes approaches to assess pharmacokinetics and how drug efflux and uptake transporters impact oral bioavailability Helps readers reduce the failure rate of drug candidates when transitioning from the bench to the clinic during development Explains how preclinical animal models used in preclinical testing and in vitro tools translate to humans, which is an underappreciated and complicated area of drug development Includes chapters about pharmacokinetic modelling, the Biopharmaceutics Drug Disposition Classification System (BDDCS), and the Extended Clearance Classification System (ECCS) Has tutorials for applying strategies to medicinal chemistry practices of drug discovery/development
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191.100000 USD
Hardback
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Pesticide dose is a parameter that is central to pesticide efficacy, effects of pesticides on non-target organisms, evolution of pesticide resistance, and non-intended pesticide effects such as hormesis (the stimulatory effect of a sub-toxic dose of a toxin). This book details and documents the reasons why only a tiny fraction ...
Pesticide Dose: Effects on the Environment and Target and Non-Target Organisms
Pesticide dose is a parameter that is central to pesticide efficacy, effects of pesticides on non-target organisms, evolution of pesticide resistance, and non-intended pesticide effects such as hormesis (the stimulatory effect of a sub-toxic dose of a toxin). This book details and documents the reasons why only a tiny fraction of applied pesticides reach their desired molecular targets in the pests for which they are intended. This is followed by a discussion of the relationship of dose to efficacy levels and the practical implications of this. Pesticide movement to non-target organisms by drift and other processes has become a topic of great interest and is thoroughly covered. The book ends with a review of the effects of herbicides on non-target terrestrial plants with large differences in sensitivities to low herbicides doses. This volume gives the reader an appreciation for the complexity of pesticide dose effects.
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168.000000 USD
Hardback
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Continuing food poisoning outbreaks around the globe have put fresh produce safety at the forefront of food research. Global Safety of Fresh Produce provides a detailed and comprehensive overview of best practice for produce safety throughout the food chain, and unique coverage of commercial technologies for fresh produce safety. Part ...
Global Safety of Fresh Produce: A Handbook of Best Practice, Innovative Commercial Solutions and Case Studies
Continuing food poisoning outbreaks around the globe have put fresh produce safety at the forefront of food research. Global Safety of Fresh Produce provides a detailed and comprehensive overview of best practice for produce safety throughout the food chain, and unique coverage of commercial technologies for fresh produce safety. Part one covers the production and regulation of fresh produce on the agricultural level, including issues of niche farm fresh products, FDA regulation, and zoonotic transfer of pathogens from animals to farm products. Part two moves on to look at safety and environmental issues surrounding fresh produce processing, such as postharvest washing, alternative sanitizers, and using produce waste as animal feed. Part three focuses on current and emerging commercial solutions for fresh produce safety, like ionizing radiation and edible coatings, and part four covers methods of laboratory testing and related legislation. The final section of the book covers a series of case studies of fresh produce safety breaches, including European E. coli outbreaks in sprouts and leafy greens, and the illegal use of fluorescent whitening agents (FWAs) in China. This book is an essential text for R&D managers in the fresh produce industry, quality control professionals working with fresh produce throughout the food chain, postgraduate students, and academic researchers with an interest in fresh produce safety.
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147.97 USD
Hardback
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Traditional systems of medicine are fast emerging as viable alternatives to modern medical science. Further, in recent years the emphasis on botanicals as source for drug discovery and development has been realized globally. Added to this, the safer profile of herbal drugs combined with their low costs make them ideal ...
Recent Advances in Herbal Drug Research and Therapy
Traditional systems of medicine are fast emerging as viable alternatives to modern medical science. Further, in recent years the emphasis on botanicals as source for drug discovery and development has been realized globally. Added to this, the safer profile of herbal drugs combined with their low costs make them ideal targets for newer drugs. As in the modern system of medicine, viz. allopathy, herbal drugs form an inseparable part of the management of various disorders. The concept of scientific validation of the basis of traditional uses of herbal medicines has given birth to a new concept of reverse pharmacology, and interactions between traditional and modern systems of medicine are being increasingly encouraged. Recent Advances in Herbal Drug Research and Therapy showcases some of these crucial and emerging issues relating to herbal drugs. This compilation is a judicious combination of research and conventional aspects on the subject of herbal drugs, their pharmacology and therapeutic applications. Some very relevant general and systemic pharmacological as well as toxicological aspects have been highlighted by some of the leading experts in this field. The book will be of interest to students, scientists, teachers and other health professionals in the area of pharmacology, toxicology and allied health sciences. Spread in 26 chapters the book broadly focuses on: Standardization and quality control of herbal drugs Regulatory issues like ethics and pharmacovigilance with herbals Clinical research with herbal drugs Herbogenomics Herb-drug interactions Potential therapeutics uses of herbal drugs focusing on various systemic disorders of cardiorespiratory, endocrinal, neuropsychiatric gastrointestinal systems and cancer Herbal drugs and environmental toxicology
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USD
Hardback
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A single-source reference with a broad and holistic overview of nonclinical studies, this book offers critical training material and describes regulations of nonclinical testing through guidelines, models, case studies, practical examples, and worldwide perspectives. The book: * Provides a complete overview of nonclinical study organization, conduct, and reporting and describes ...
The Role of the Study Director in Nonclinical Studies: Pharmaceuticals, Chemicals, Medical Devices, and Pesticides
A single-source reference with a broad and holistic overview of nonclinical studies, this book offers critical training material and describes regulations of nonclinical testing through guidelines, models, case studies, practical examples, and worldwide perspectives. The book: * Provides a complete overview of nonclinical study organization, conduct, and reporting and describes the roles and responsibilities of a Study Director to manage an effective study * Covers regulatory and scientific concepts, including international testing and Good Laboratory Practice (GLP), compliance with guidelines, and animal models * Features a concluding chapter that compiles case studies / lessons learned from those that have served as a Study Director for many years * Addresses the entire spectrum of nonclinical testing, making it applicable to those in the government, laboratories and those actively involved in in all sectors of industry
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140.960000 USD

The Role of the Study Director in Nonclinical Studies: Pharmaceuticals, Chemicals, Medical Devices, and Pesticides

Hardback
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With an emphasis on the fundamental and practical aspects of ADME for therapeutic proteins, this book helps readers strategize, plan and implement translational research for biologic drugs. Details cutting-edge ADME (absorption, distribution, metabolism and excretion) and PKPD (pharmacokinetic / pharmacodynamics) modeling for biologic drugs Combines theoretical with practical aspects of ...
ADME and Translational Pharmacokinetics / Pharmacodynamics of Therapeutic Proteins: Applications in Drug Discovery and Development
With an emphasis on the fundamental and practical aspects of ADME for therapeutic proteins, this book helps readers strategize, plan and implement translational research for biologic drugs. Details cutting-edge ADME (absorption, distribution, metabolism and excretion) and PKPD (pharmacokinetic / pharmacodynamics) modeling for biologic drugs Combines theoretical with practical aspects of ADME in biologic drug discovery and development and compares innovator biologics with biosimilar biologics and small molecules with biologics, giving a lessons-learned perspective Includes case studies about leveraging ADME to improve biologics drug development for monoclonal antibodies, fusion proteins, pegylated proteins, ADCs, bispecifics, and vaccines Presents regulatory expectations and industry perspectives for developing biologic drugs in USA, EU, and Japan Provides mechanistic insight into biodistribution and target-driven pharmacokinetics in important sites of action such as tumors and the brain
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163.800000 USD
Hardback
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Each day, headlines warn that baby bottles are leaching dangerous chemicals, nonstick pans are causing infertility, and plastic containers are making us fat. What if green chemistry could change all that? What if rather than toxics, our economy ran on harmless, environmentally-friendly materials? Elizabeth Grossman, an acclaimed journalist who brought ...
Chasing Molecules: Poisonous Products, Human Health, and the Promise of Green Chemistry
Each day, headlines warn that baby bottles are leaching dangerous chemicals, nonstick pans are causing infertility, and plastic containers are making us fat. What if green chemistry could change all that? What if rather than toxics, our economy ran on harmless, environmentally-friendly materials? Elizabeth Grossman, an acclaimed journalist who brought national attention to the contaminants hidden in computers and other high tech electronics, now tackles the hazards of ordinary consumer products. She shows that for the sake of convenience, efficiency, and short-term safety, we have created synthetic chemicals that fundamentally change, at a molecular level, the way our bodies work. The consequences range from diabetes to cancer, reproductive and neurological disorders. Yet it's hard to imagine life without the creature comforts current materials provide - and Grossman argues we do not have to. A scientific revolution is introducing products that are 'benign by design', developing manufacturing processes that consider health impacts at every stage, and is creating new compounds that mimic rather than disrupt natural systems. Through interviews with leading researchers, Grossman gives us a first look at this radical transformation. Green chemistry is just getting underway, but it offers hope that we can indeed create products that benefit health, the environment, and industry.
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16.83 USD
Hardback
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Homeostasis and Toxicology of Non-Essential Metals synthesizes the explosion of new information on the molecular, cellular, and organismal handling of metals in fish in the past 15 years. These elements are no longer viewed by fish physiologists as heavy metals that kill fish by suffocation, but rather as interesting moieties ...
Fish Physiology: Homeostasis and Toxicology of Non-Essential Metals, Volume 31b
Homeostasis and Toxicology of Non-Essential Metals synthesizes the explosion of new information on the molecular, cellular, and organismal handling of metals in fish in the past 15 years. These elements are no longer viewed by fish physiologists as heavy metals that kill fish by suffocation, but rather as interesting moieties that enter and leave fish by specific pathways, which are subject to physiological regulation. The metals featured in this volume are those about which there has been most public and scientific concern, and therefore are those most widely studied by fish researchers. Metals such as Ag, Al, Cd, Pb, Hg, As, Sr, and U have no known nutritive function in fish at present, but are toxic at fairly low levels. The companion volume, Homeostasis and Toxicology of Essential Metals, Volume 31A, covers metals that are either proven to be or are strongly suspected to be essential in trace amounts, yet are toxic in higher doses. Metals such as Cu, Zn, Fe, Ni, Co, Se, Mo and Cr. In addition, three chapters in Volumes 31A and 31B on Basic Principles (Chapter 1, 31A), Field Studies and Ecological Integration (Chapter 9, 31A) and Modeling the Physiology and Toxicology of Metals (Chapter 9, 31B) act as integrative summaries and make these two volumes a vital set for readers.
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121.800000 USD
Hardback
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This wide-ranging text reviews the wealth of recent research on assessing and managing the risks from pesticide, veterinary and other chemical residues in food. After an introductory chapter on the key issues in food toxicology, Part one covers the assessment and management of risks, with individual chapters on genetic susceptibility ...
Pesticide, Veterinary and Other Residues in Food
This wide-ranging text reviews the wealth of recent research on assessing and managing the risks from pesticide, veterinary and other chemical residues in food. After an introductory chapter on the key issues in food toxicology, Part one covers the assessment and management of risks, with individual chapters on genetic susceptibility to dietary carcinogens, good agricultural practice and HACCP systems, targeted and rapid methods for analysing residues in food and ways of assessing the mutagenicity of chemicals in food. Part two looks at veterinary residues, covering their safety, toxicology and detection. Part three examines pesticides, with chapters on surveillance and detection methods for fungicides and herbicides. In the final part, there are chapters summarising a wide range of other chemical residues in food, from xenostrogens/endocrine disruptors and dietary estrogens to polycyclic aromatic hydrocarbons, dioxins and polychlorinated biphenyls. Pesticide, veterinary and other residues in food is a standard reference for all those concerned with ensuring the safety of food.
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175.68 USD
Hardback
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Homeostasis and Toxicology of Essential Metals synthesizes the explosion of new information on the molecular, cellular, and organismal handling of metals in fish in the past 15 years. These elements are no longer viewed by fish physiologists as heavy metals that kill fish by suffocation, but rather as interesting moieties ...
Fish Physiology: Homeostasis and Toxicology of Essential Metals, Volume 31a
Homeostasis and Toxicology of Essential Metals synthesizes the explosion of new information on the molecular, cellular, and organismal handling of metals in fish in the past 15 years. These elements are no longer viewed by fish physiologists as heavy metals that kill fish by suffocation, but rather as interesting moieties that enter and leave fish by specific pathways, which are subject to physiological regulation. The metals featured in this volume are those about which there has been most public and scientific concern, and therefore are those most widely studied by fish researchers. Metals such as Cu, Zn, Fe, Ni, Co, Se, Mo and Cr are either proven to be or are strongly suspected to be essential in trace amounts, yet are toxic in higher doses. The companion volume, Homeostasis and Toxicology of Non-Essential Metals, Volume 31B, covers metals that have no known nutritive function in fish at present, but which are toxic at fairly low levels, such as Ag, Al, Cd, Pb, Hg, As, Sr, and U. In addition, three chapters in Volumes 31A and 31B on Basic Principles (Chapter 1, 31A), Field Studies and Ecological Integration (Chapter 9, 31A) and Modeling the Physiology and Toxicology of Metals (Chapter 9, 31B) act as integrative summaries and make these two volumes a vital set for readers.
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55.14 USD
Hardback
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Highlighting international approaches; the book details strategies to minimize contamination, residue monitoring programs, and classes of drugs and chemicals that pose contaminant risk in livestock. * Focuses attention on drug and chemical residues in edible animal products * Covers novel computational, statistical, and mathematical strategies for dealing with chemical exposures ...
Strategies for Reducing Drug and Chemical Residues in Food Animals: International Approaches to Residue Avoidance, Management, and Testing
Highlighting international approaches; the book details strategies to minimize contamination, residue monitoring programs, and classes of drugs and chemicals that pose contaminant risk in livestock. * Focuses attention on drug and chemical residues in edible animal products * Covers novel computational, statistical, and mathematical strategies for dealing with chemical exposures in food animals * Details major drug classes used in food animal production and their residue risks * Highlights efforts at harmonizing and the differences among areas like US, EU, Canada, Australia, South America, China, and Asia, where the issue of chemical exposures has significant impact on livestock products * Ties veterinary clinical practice and the use of these drugs in food animals with regulatory standards and mitigation practices
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97.53 USD
Hardback
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