Uveal Melanoma: A Model for Exploring Fundamental Cancer Biology

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Uveal melanoma is the most common intraocular malignancy in adults, yet little is known about the factors that predispose patients to develop the disease. However, the availability of several uveal melanoma cell lines has fostered novel in vitro and in vivo studies that have added to our knowledge about the immunology, genetics, and molecular biology of uveal melanoma, revealing, for instance, that that uveal melanoma and cutaneous melanoma are remarkably different diseases. Presenting this important research into the area, Uveal Melanoma summarizes developments regarding the biology and metastasis of the disease, and provides insight into the pathobiology of this type of melanoma, as well as a discussion of the necessary expansion of treatment options - thus shedding new light on what is undoubtedly a highly significant area of study.