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Rift Valley fever (RVF) is one of the most serious transboundary animal diseases. It is a mosquito-borne viral disease, which causes periodic severe epidemics, principally involving ruminant animals. This manual provides information on the nature of RVF and the principles and strategic options for its prevention, control and elimination. Guidelines are provided for individual countries threatened by RVF to formulate their overall national policy on control and eradication of a possible incurision of the disease.