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Chapters 1 to 5 include a description of the philosophy, foundations, and construction (methodology) of the formalism, including the derivation of a nonequilibrium grand-canonical ensemble for far-from-equilibrium systems as well as the derivation of a quantum nonlinear kinetic theory and a response function theory together with a theory of scattering. In chapter 6 applications of the theory are cataloged, making comparisons with experimental data (a basic step for the validation of any theory). Chapter 7 is devoted to the description of irreversible thermodynamics, providing a far-reaching generalization of Informational-Statistical Thermodynamics. The last chapter gives an overall picture of the formalism, and questions and criticisms related to it are discussed.