As Executive Director of the H.H. Chao Comprehensive Digestive Disease Center, University of California, Irvine, Dr. Chang brings the wealth of his experience and knowledge to the topic of interventional endoscopic ultrasound. His issue is divided into two sections, the first dealing with the best practices of interventional EUS. Articles in this section address FNA of solid pancreatic tumors, pancreatic cysts, diagnosis of SMT's, lung cancer staging, pancreatic drainage, and celiac neurolysis. The second section addresses emerging technologies for intervention EUS. These articles discuss pancreatic cyst ablation, vascular access and therapy, anti-tumor agents, fiducial markers and brachytherapy, image enhancement, tumor ablation, and anastomosis.