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Leading researchers are specially invited to provide a complete understanding of a key topic within the multidisciplinary fields of physiology, biochemistry and pharmacology. In a form immediately useful to scientists, this periodical aims to filter, highlight and review the latest developments in these rapidly advancing fields.
Reviews of Physiology, Biochemistry and Pharmacology, Vol. 175
Leading researchers are specially invited to provide a complete understanding of a key topic within the multidisciplinary fields of physiology, biochemistry and pharmacology. In a form immediately useful to scientists, this periodical aims to filter, highlight and review the latest developments in these rapidly advancing fields.
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167.990000 USD

Reviews of Physiology, Biochemistry and Pharmacology, Vol. 175

Hardback
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This book discusses various fundamental aspects of polysaccharide based nano-biocarrier drug delivery systems and its application in the delivery of small molecules, proteins, peptides, oligonucleotides and genes. It also discusses advances in drug delivery systems in treatment of cancer, cardiovascular, pulmonary, and infectious diseases.
Polysaccharide based Nano-Biocarrier in Drug Delivery
This book discusses various fundamental aspects of polysaccharide based nano-biocarrier drug delivery systems and its application in the delivery of small molecules, proteins, peptides, oligonucleotides and genes. It also discusses advances in drug delivery systems in treatment of cancer, cardiovascular, pulmonary, and infectious diseases.
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264.47 USD

Polysaccharide based Nano-Biocarrier in Drug Delivery

Hardback
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This book is an international effort to standardize the language, terms, and methods used in ocular toxicology.With over 300 color illustrations this consensus volume provides standards and harmonization for procedures, terminology, and scoring schemes for ocular toxicology. it is essential for industry, pharmaceutical companies, and governmental agencies to help improve ...
Standards for Ocular Toxicology and Inflammation
This book is an international effort to standardize the language, terms, and methods used in ocular toxicology.With over 300 color illustrations this consensus volume provides standards and harmonization for procedures, terminology, and scoring schemes for ocular toxicology. it is essential for industry, pharmaceutical companies, and governmental agencies to help improve the drug development process and to reduce and refine the use of animals in research. Standards for Ocular Toxicology and Inflammation is endorsed by the American College of Veterinary Ophthalmologists.
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178.490000 USD

Standards for Ocular Toxicology and Inflammation

Hardback
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Antisense-based drugs are part of a growing number of pharmaceutical and biotech programs to treat diseases including cancer, diabetes, and ALS. Reviewing fundamentals and offering guidelines for drug discovery and development, this book is a practical guide from the safety assessment to clinical experience with antisense oligonucleotides. Examines principles and ...
Oligonucleotide-Based Drugs and Therapeutics: Preclinical and Clinical Considerations for Development
Antisense-based drugs are part of a growing number of pharmaceutical and biotech programs to treat diseases including cancer, diabetes, and ALS. Reviewing fundamentals and offering guidelines for drug discovery and development, this book is a practical guide from the safety assessment to clinical experience with antisense oligonucleotides. Examines principles and tools for scientists in both pre-clinical and clinical settings and how to apply them to antisense oligonucleotides Reviews fundamentals and provides guidelines for scientists in drug design and discovery to increase efficiency, assessment, and success of drug candidates Helps readers understand antisense molecules and their targets, biochemistry and toxicity mechanisms, roles in disease, and applications for safety and therapeutics Includes interdisciplinary perspectives, from both academia and research, on a hot topic that combines pharmacology, toxicology, biology, and medicinal chemistry to advance our understanding and application of therapeutics
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236.250000 USD

Oligonucleotide-Based Drugs and Therapeutics: Preclinical and Clinical Considerations for Development

Hardback
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Key features: Serves as a standard reference for researchers, teachers and students of various disciplines such as Fisheries Science, Marine Biology, Life Sciences, Biotechnology, Natural Products, and Pharmacy, their libraries, and as a valuable guide for pharmaceutical companies involved in the development of new drugs from marine sponges Presents the ...
Biology and Ecology of Pharmaceutical Marine Sponges
Key features: Serves as a standard reference for researchers, teachers and students of various disciplines such as Fisheries Science, Marine Biology, Life Sciences, Biotechnology, Natural Products, and Pharmacy, their libraries, and as a valuable guide for pharmaceutical companies involved in the development of new drugs from marine sponges Presents the taxonomy, common name, global distribution, and habitat of 250 species of marine sponges Provides the diagnostic features and pharmaceutical compounds (along with their chemical structure and activities) of 450 species of marine sponges Includes more than 500 detailed illustrations Biology and Ecology of Pharmaceutical Marine Sponges is the first comprehensive book of its kind written by scientists from both the Marine Biology and Pharmacy disciplines to fill the long-felt need for a marine natural products book devoted exclusively to sponges. Sponges are the most primitive multicelled animals that have existed for 700 - 800 million years. Despite their wide range of functional roles, not much is known about them. Marine sponges are responsible for more than 5,300 pharmaceutical products and some species have the potential to provide future drugs to prevent and treat important medical conditions such as cancer, a range of viral diseases, malaria, and inflammatory diseases. Nucleosides derived from sponges were the basis for the synthesis of Ara-C, the first marine-derived anticancer agent, currently used in the routine treatment of patients with leukemia and lymphoma. Marine sponges are the potential sources of many unique metabolites with anticancer,anti-inflammatory, antibiotic, antiviral, antimalarial, and immune or neurosuppressive properties. Although many bioactives have been discovered in marine sponges, only a few of these compounds have been commercialized. This book hopes to change that, providing the taxonomy, common name, global distribution, habitat, diagnostic features and pharmaceutical compounds (along with their chemical structure and activities) of 450 species of marine sponges, accompanied by high-quality illustrations. The book should be a standard reference for students, researchers and teachers of disciplines such as Fisheries Science, Marine Biology, Biochemistry, Biotechnology and Pharmacy and a valuable guide for pharmaceutical companies involved in the development of new drugs from marine sponges.
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262.450000 USD

Biology and Ecology of Pharmaceutical Marine Sponges

by Anbu Jeba Sunilson, Santhanam Ramesh, Ramasamy Santhanam
Hardback
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This work brings together a wealth of data regarding the reference values and factors of variation in biochemical parameters used by camel veterinarians and scientists to determine these animals' nutritional and clinical status. It also explores several technical aspects involved in determining these parameters, sampling procedures, and essential elements in ...
Camel Clinical Biochemistry and Hematology
This work brings together a wealth of data regarding the reference values and factors of variation in biochemical parameters used by camel veterinarians and scientists to determine these animals' nutritional and clinical status. It also explores several technical aspects involved in determining these parameters, sampling procedures, and essential elements in the interpretation of the results. Though many texts are available on small and large ruminants, much less is known about species confined to the marginal zones of tropical and Mediterranean countries, such as camels. This book addresses precisely this research gap, on the one hand by presenting an extensive review of the literature, and on the other by synthesizing the outcomes of the authors' numerous previous works. In veterinary medicine, blood tests to help diagnose diseases in cattle were first proposed nearly a century ago, but were mainly developed in the 1960s, initially at specialized research or veterinary services laboratories, and eventually, with the advent of new equipment and the miniaturization of the analyzers, finding their way into veterinarians' cabinets. Beyond their diagnostic value, veterinary surgeons and zootechnicians also speculated on the potential use of blood tests to evaluate animals' nutritional status. Thus, a whole range of analyses are now proposed to the stakeholders responsible for animal health. Such analyses could help to define a metabolic profile, which would offer a valuable decision-making tool for experts and researchers alike.
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209.990000 USD

Camel Clinical Biochemistry and Hematology

by Mohammed Bengoumi, Bernard Faye
Hardback
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Summary: The focus of this book is on how the U.S. FDA will approve biosimilar drugs, as learned from recent approvals by the FDA. Understanding the limitations of the statutory limits and non-inferiority testing are presented as tools to obviate patient trials and minimize testing of immunogenicity. An in-depth scientific, ...
Biosimilarity: The FDA Perspective
Summary: The focus of this book is on how the U.S. FDA will approve biosimilar drugs, as learned from recent approvals by the FDA. Understanding the limitations of the statutory limits and non-inferiority testing are presented as tools to obviate patient trials and minimize testing of immunogenicity. An in-depth scientific, mathematical and statistical view of the tools required to establish biosimilarity of biological drugs of different complexity -- a must for every developer of biosimilars. Features: First comprehensive analysis based on new guidelines and approval packages of several biosimilars Presents the first approach to challenge FDA in reducing or eliminating any testing in patients. Provides a comprehensive understanding of the U.S. statutory requirements vis-a-vis the regulatory guidelines Provides model CQA and Analytical Similarity testing protocols for cytokines and monoclonal antibodies Allow creation of a fast-to-market pathway to develop biosimilars
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206.46 USD

Biosimilarity: The FDA Perspective

by Sarfaraz K Niazi
Hardback
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Following the success of the first edition, this book is designed to provide practical and timely information for toxicologic pathologists working in pharmaceutical drug discovery and development. The majority of the book (Organ Systems) will provide detailed descriptions of histopathological lesions observed in drug development. In addition, it will provide ...
Toxicologic Pathology: Nonclinical Safety Assessment, Second Edition
Following the success of the first edition, this book is designed to provide practical and timely information for toxicologic pathologists working in pharmaceutical drug discovery and development. The majority of the book (Organ Systems) will provide detailed descriptions of histopathological lesions observed in drug development. In addition, it will provide information to assist the pathologist in making determinations of the origin of lesions as well as its relevance to human risk. Toxicologic Pathology: Nonclinical Safety Assessment, Second Edition includes 2 new concept chapters. The first of the new chapters address approaches for the evaluation of unique therapeutic modalities such as cell therapies, gene therapies, and gene expression knockdown therapies. While these still represent new developing therapeutic approaches, there has been significant experience with the therapeutic modalities in the last 5 years. The second new chapter addresses the nonclinical safety assessment of medical devices, a topic of increasing importance that was not addressed in a unique chapter in the first edition. The other concept chapters have been updated and cover important topics including the overview of drug development; principles of nonclinical safety assessment; an introduction to toxicologic pathology; techniques used in toxicologic pathology, clinical pathology, toxicokinetics, and drug development toxicogenomics; and spontaneous lesions. The 13 organ system chapters provide the specifics related to pathologic characteristics, differential diagnosis, and interpretation of toxic responses in each organ system. These chapters are specifically important for the bench pathologist but also for the toxicologist who interacts with pathologists and function as study toxicologists and project team representatives in the drug development arena.
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383.91 USD

Toxicologic Pathology: Nonclinical Safety Assessment, Second Edition

Hardback
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Drug Delivery Nanosystems for Biomedical Application reviews some of the most challenging nanosystems with different routes of delivery that are useful for specific drugs, from both efficacy and bioavailability points-of-view. The chapters explore how this area is developing, the present state of the field, and future developments, in particular, inorganic, ...
Drug Delivery Nanosystems for Biomedical Applications
Drug Delivery Nanosystems for Biomedical Application reviews some of the most challenging nanosystems with different routes of delivery that are useful for specific drugs, from both efficacy and bioavailability points-of-view. The chapters explore how this area is developing, the present state of the field, and future developments, in particular, inorganic, metallic, polymeric, composite and lipid nanosystems and their possible evolution to clinical applications. The book is a valuable research reference for both researchers and industrial partners who are not only interested in learning about this area, but also want to gain insights on how to move towards translational research.
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189.000000 USD

Drug Delivery Nanosystems for Biomedical Applications

by Sharma
Hardback
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This first monograph in the new AAPS book series concisely reviews important aspects of powder and particle systems and the critical quality attributes that should be used as a guide to future developments intended to maximize the control of product quality and performance. Drs. Hickey and Giovagnoli have written an ...
Pharmaceutical Powder and Particles
This first monograph in the new AAPS book series concisely reviews important aspects of powder and particle systems and the critical quality attributes that should be used as a guide to future developments intended to maximize the control of product quality and performance. Drs. Hickey and Giovagnoli have written an essential primer for any scientists involved in powder or particle research and manufacturing. It is appropriate for those just entering the field or as a rapid reference for the experienced pharmaceutical scientist. The authors have both academic and industrial experience and the coverage includes solid state chemistry; crystallization; physical processes; particle size and distribution;particle interaction;manufacturing processes;quality by design;and a general discussion of the industry. Pharmaceutical Powder and Particles is intended to concisely review important aspects of powder and particle systems and the critical quality attributes that should be used as a guide to future developments intended to maximize the control of product quality and performance.
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167.990000 USD

Pharmaceutical Powder and Particles

by Stefano Giovagnoli, Anthony J Hickey
Hardback
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Since the publication of the first edition in 2000, there has been an explosive growth of literature in biopharmaceutical research and development of new medicines. This encyclopedia (1) provides a comprehensive and unified presentation of designs and analyses used at different stages of the drug development process, (2) gives a ...
Encyclopedia of Biopharmaceutical Statistics - Four Volume Set
Since the publication of the first edition in 2000, there has been an explosive growth of literature in biopharmaceutical research and development of new medicines. This encyclopedia (1) provides a comprehensive and unified presentation of designs and analyses used at different stages of the drug development process, (2) gives a well-balanced summary of current regulatory requirements, and (3) describes recently developed statistical methods in the pharmaceutical sciences. Features of the Fourth Edition: 1. 78 new and revised entries have been added for a total of 308 chapters and a fourth volume has been added to encompass the increased number of chapters. 2. Revised and updated entries reflect changes and recent developments in regulatory requirements for the drug review/approval process and statistical designs and methodologies. 3. Additional topics include multiple-stage adaptive trial design in clinical research, translational medicine, design and analysis of biosimilar drug development, big data analytics, and real world evidence for clinical research and development. 4. A table of contents organized by stages of biopharmaceutical development provides easy access to relevant topics. About the Editor: Shein-Chung Chow, Ph.D. is currently an Associate Director, Office of Biostatistics, U.S. Food and Drug Administration (FDA). Dr. Chow is an Adjunct Professor at Duke University School of Medicine, as well as Adjunct Professor at Duke-NUS, Singapore and North Carolina State University. Dr. Chow is the Editor-in-Chief of the Journal of Biopharmaceutical Statistics and the Chapman & Hall/CRC Biostatistics Book Series and the author of 28 books and over 300 methodology papers. He was elected Fellow of the American Statistical Association in 1995.
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1578.29 USD

Encyclopedia of Biopharmaceutical Statistics - Four Volume Set

Hardback
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This book focuses on analytical similarity assessment in biosimilar product development following the FDA's recommended stepwise approach for obtaining totality-of-the-evidence for approval of biosimilar products. It covers concepts such as the tiered approach for assessment of similarity of critical quality attributes in the manufacturing process of biosimilar products, models/methods like ...
Analytical Similarity Assessment in Biosimilar Product Development
This book focuses on analytical similarity assessment in biosimilar product development following the FDA's recommended stepwise approach for obtaining totality-of-the-evidence for approval of biosimilar products. It covers concepts such as the tiered approach for assessment of similarity of critical quality attributes in the manufacturing process of biosimilar products, models/methods like the statistical model for classification of critical quality attributes, equivalence tests for critical quality attributes in Tier 1 and the corresponding sample size requirements, current issues, and recent developments in analytical similarity assessment.
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221.81 USD

Analytical Similarity Assessment in Biosimilar Product Development

by Shein-Chung Chow
Hardback
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Written by experts in the field of pharmacovigilance and patient safety, this concise resource provides a succinct, easy-to-digest overview of an increasingly critical area of medical safety. Drs. Thao Doan, Cheryl Renz, Fabio Lievano, Mondira Bhattacharya, and Linda Scarazzini provide essential information for health care professionals, clinical researchers, and regulators ...
Pharmacovigilance: A Practical Approach
Written by experts in the field of pharmacovigilance and patient safety, this concise resource provides a succinct, easy-to-digest overview of an increasingly critical area of medical safety. Drs. Thao Doan, Cheryl Renz, Fabio Lievano, Mondira Bhattacharya, and Linda Scarazzini provide essential information for health care professionals, clinical researchers, and regulators who need a comprehensive, up-to-date source of information on the principles and practice of pharmacovigilance. Covers the evolving regulatory landscape, as well as current and future use of digital technologies. Uses case studies to ensure content is relevant to everyday practice. Discusses behavioral science and patient perspectives, risk communication, and new frontiers in pharmacovigilance. Consolidates today's available information on this timely topic into one convenient resource.
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126.25 USD

Pharmacovigilance: A Practical Approach

Paperback / softback
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This book provides an essential update on the startling array of novel insecticidal toxins and drugs produced by the fascinating bacterium Photorhabdus. The respective chapters describe everything from the detailed molecular biology of the `Toxin complexes' or Tc's to the complexity of insect immune response in relation to both the ...
The Molecular Biology of Photorhabdus Bacteria
This book provides an essential update on the startling array of novel insecticidal toxins and drugs produced by the fascinating bacterium Photorhabdus. The respective chapters describe everything from the detailed molecular biology of the `Toxin complexes' or Tc's to the complexity of insect immune response in relation to both the bacterium and its nematode vector. The volume covers both primary (toxin production and regulation) and secondary (natural product synthesis and regulation) metabolism and emphasises the potential use of toxins and drugs in both agriculture and medicine. It also discusses in detail two totally novel quorum sensing mechanisms and the likely role of LuxR solos in sensing the presence of different bacterial hosts. Lastly, the book explores the unique case of P. asymbiotica, which seems to have evolved the ability to infect both insects and humans. This synthesis proves that Photorhabdus truly does offer a `gold mine' for the discovery of novel insecticidal proteins and novel natural products with potential uses in agriculture and medicine alike.
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209.990000 USD

The Molecular Biology of Photorhabdus Bacteria

Paperback / softback
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This volume aims to connect current ideas and concepts about GI disorders with the search for novel therapeutics. Towards this goal, authors provide a timely state-of-the-art overview of the GI tract in health and disease, current treatment approaches and ongoing developments in drug discovery, and their potential for the better ...
Gastrointestinal Pharmacology
This volume aims to connect current ideas and concepts about GI disorders with the search for novel therapeutics. Towards this goal, authors provide a timely state-of-the-art overview of the GI tract in health and disease, current treatment approaches and ongoing developments in drug discovery, and their potential for the better treatment of patients with GI disorders.
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367.490000 USD

Gastrointestinal Pharmacology

Paperback / softback
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Medicines, Ethics and Practice: The professional guide for pharmacists is the Royal Pharmaceutical Society's established professional guide for pharmacists. This 42nd edition is a revised practical resource which helps pharmacists practice confidently and professionally. It embeds professionalism at the heart of decision-making processes and provides essential information, supporting the pharmacist ...
Medicines, Ethics and Practice 2018: The professional guide for pharmacists
Medicines, Ethics and Practice: The professional guide for pharmacists is the Royal Pharmaceutical Society's established professional guide for pharmacists. This 42nd edition is a revised practical resource which helps pharmacists practice confidently and professionally. It embeds professionalism at the heart of decision-making processes and provides essential information, supporting the pharmacist in their day-to-day practice.
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93.85 USD

Medicines, Ethics and Practice 2018: The professional guide for pharmacists

by Royal Pharmaceutical Society
Paperback / softback
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This book sheds new light on the diagnosis and treatment of Heart Failure in adult patients with congenital heart disease. This is a rapidly growing clinical issue for this group of patients and the clinical teams caring for them. The book highlights the major clinical dilemmas in diagnosing heart failure ...
Heart Failure in Adult Congenital Heart Disease
This book sheds new light on the diagnosis and treatment of Heart Failure in adult patients with congenital heart disease. This is a rapidly growing clinical issue for this group of patients and the clinical teams caring for them. The book highlights the major clinical dilemmas in diagnosing heart failure in patients with a lifelong cardiac condition and describes in details the utility of biomarkers, complex imaging and functional tests, e.g. the cardiopulmonary exercise testing. A step-wise approach to treatment is described from drug therapy through to devices and transplantation. As such, the book offers an essential guide for cardiologists and cardiac surgeons looking to optimize the management of patients with delicate physiology and complex disease.
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135.450000 USD

Heart Failure in Adult Congenital Heart Disease

Hardback
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This is the ideal book for anyone contemplating starting a career in, or shifting their career to, studying the dynamics that drive cancer progression and its response to therapy. Topics include the theory and population genetics of cancers, genetic diversity within tumors (intra-tumor heterogeneity), understanding how mutant clones expand in ...
Frontiers in Cancer Research: Evolutionary Foundations, Revolutionary Directions
This is the ideal book for anyone contemplating starting a career in, or shifting their career to, studying the dynamics that drive cancer progression and its response to therapy. Topics include the theory and population genetics of cancers, genetic diversity within tumors (intra-tumor heterogeneity), understanding how mutant clones expand in tissues, the role of cancer stem cells in the dynamics of tumors, the evolution of metastasis, and how to improve cancer therapy by addressing the evolution of cancers in response to our interventions. There are also chapters on the patterns of cancer susceptibility in humans due to a mismatch between our modern environment and the environment in which our ancestors evolved, as well as a chapter on the evolution of cancer suppression mechanisms that have evolved in different species, particularly the large long-lived animals like elephants and whales that are better at suppressing cancers than humans. This book serves as a primer on the evolutionary and ecological theory of cancer- the framework upon which all the details of cancer may be hung. It is ideal for oncologists and cancer researchers interested in evolutionary theory, and evolutionary biologists and ecologists interested in gaining insights into cancer development and prevention.
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209.990000 USD

Frontiers in Cancer Research: Evolutionary Foundations, Revolutionary Directions

Paperback / softback
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Natural, popular, and inexpensive, apple cider vinegar is the latest health trend. Learn more about its powers with this attractive and easy-to-use illustrated guide--complete with recipes! We all know that apple cider vinegar is a useful addition to the pantry and a tasty ingredient in cooking. But it can do ...
Apple Cider Vinegar Handbook
Natural, popular, and inexpensive, apple cider vinegar is the latest health trend. Learn more about its powers with this attractive and easy-to-use illustrated guide--complete with recipes! We all know that apple cider vinegar is a useful addition to the pantry and a tasty ingredient in cooking. But it can do more than just add flavor. With the potential to cure an upset stomach, treat a sore throat, aid weight loss, and more, apple cider vinegar is one of today's handiest all-natural remedies. The Apple Cider Vinegar Handbook shows you why this inexpensive liquid is a must-have in your home and how to use it to achieve optimum health.
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22.17 USD

Apple Cider Vinegar Handbook

by Amy Leigh Mercree
Paperback / softback
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This volume describes the mechanisms which bacteria have created to secure their survival, proliferation and dissemination by subverting the actin cytoskeleton of host cells. Bacteria have developed a veritable arsenal of toxins, effector proteins and virulence factors that allow them to modify the properties of the intracellular actin cytoskeleton for ...
The Actin Cytoskeleton and Bacterial Infection
This volume describes the mechanisms which bacteria have created to secure their survival, proliferation and dissemination by subverting the actin cytoskeleton of host cells. Bacteria have developed a veritable arsenal of toxins, effector proteins and virulence factors that allow them to modify the properties of the intracellular actin cytoskeleton for their own purposes. Bacterial factors either modify actin directly as the main component of this part of the cytoskeleton or functionally subvert regulatory or signalling proteins terminating at the actin cytoskeleton. In short, this volume provides an overview of the various tricks bacteria have evolved to act on actin in order to hijack this essential host cell component for their own needs. As such, it will be of interest to scientists from many fields, as well as clinicians whose work involves infectious diseases.
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209.990000 USD

The Actin Cytoskeleton and Bacterial Infection

Paperback / softback
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Reflux is an important factor in many different lung diseases and its manifestations are under recognised. The pathological basis of reflux has recently undergone major changes and clinicians' understanding has improved with diagnostic technology. This book aims to educate and inform professionals of these latest developments and give practical advice ...
Reflux Aspiration and Lung Disease
Reflux is an important factor in many different lung diseases and its manifestations are under recognised. The pathological basis of reflux has recently undergone major changes and clinicians' understanding has improved with diagnostic technology. This book aims to educate and inform professionals of these latest developments and give practical advice to their application in the clinical setting. It contains contributions written by world experts discussing their latest research, ideas and future directions in this fast moving area. Pharmacological, surgical and behavioural techniques in the prevention and treatment of reflux are discussed in each chapter. Special circumstances, such as eosinophilic inflammation in relation to asthma, cough and eosinophilic bronchitis are also highlighted. This book brings together the various different strands of research in reflux in relation to airways disease, to provide readers with a board summary of how the different but overlapping areas impacted by reflux affect the respiratory tract.
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157.490000 USD

Reflux Aspiration and Lung Disease

Hardback
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This practical collection examines methodologies originating from the benefits of genome-wide approaches to studying epigenetics, which has opened the emerging field of epigenomics. Focusing on the areas of cancer, inflammatory and autoimmune disorders, chapters discuss three main components of the epigenome and their role in the regulation of gene expression ...
Epigenetics and Gene Expression in Cancer, Inflammatory and Immune Diseases
This practical collection examines methodologies originating from the benefits of genome-wide approaches to studying epigenetics, which has opened the emerging field of epigenomics. Focusing on the areas of cancer, inflammatory and autoimmune disorders, chapters discuss three main components of the epigenome and their role in the regulation of gene expression and present a detailed method section specific to studying each component, including data analyses, troubleshooting, and feasibility in different experimental settings. The main topics are high-throughput and targeted methods for DNA methylation analysis, nucleosome position mapping, studying epigenetic effects of gut microbiota, optical imaging for detection of epigenetic aberrations in living cells, methods for microRNA, and histone code profiling. Written for the Methods in Pharmacology and Toxicology series, the book includes the kind of detail and implementation advice to encourage success in the lab. Authoritative and easily applicable, Epigenetics and Gene Expression in Cancer, Inflammatory and Immune Diseases aims to provide pharmacologists, molecular biologists, bioinformaticians, and toxicologists with a vital background on epigenetics and state-of-the-art techniques in epigenomics.
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124.950000 USD

Epigenetics and Gene Expression in Cancer, Inflammatory and Immune Diseases

Paperback / softback
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This volume focuses on antibiotics research, a field of topical significance for human health due to the worrying increase of nosocomial infections caused by multi-resistant bacteria. It covers several basic aspects, such as the evolution of antibiotic resistance and the influence of antibiotics on the gut microbiota, and addresses the ...
How to Overcome the Antibiotic Crisis: Facts, Challenges, Technologies and Future Perspectives
This volume focuses on antibiotics research, a field of topical significance for human health due to the worrying increase of nosocomial infections caused by multi-resistant bacteria. It covers several basic aspects, such as the evolution of antibiotic resistance and the influence of antibiotics on the gut microbiota, and addresses the search for novel pathogenicity blockers as well as historical aspects of antibiotics. Further topics include applied aspects, such as drug discovery based on biodiversity and genome mining, optimization of lead structures by medicinal chemistry, total synthesis and drug delivery technologies. Moreover, the development of vaccines as a valid alternative therapeutic approach is outlined, while the importance of epidemiological studies on important bacterial pathogens, the problems arising from the excessive use of antibiotics in animal breeding, and the development of innovative technologies for diagnosing the bad bugs are discussed in detail. Accordingly, the book will appeal to researchers and clinicians alike.
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230.990000 USD

How to Overcome the Antibiotic Crisis: Facts, Challenges, Technologies and Future Perspectives

Paperback / softback
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This second edition volume expands on the previous edition by discussing classic techniques, as well as new protocols that focus on the preparation of liposomes, lipid characterization, particle size and charge analysis, drug encapsulation, surface modification, stimuli response, and cellular interaction and biodistribution. Written in the highly successful Methods in ...
Liposomes: Methods and Protocols
This second edition volume expands on the previous edition by discussing classic techniques, as well as new protocols that focus on the preparation of liposomes, lipid characterization, particle size and charge analysis, drug encapsulation, surface modification, stimuli response, and cellular interaction and biodistribution. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and practical, Liposomes: Methods and Protocols, Second Edition is a valuable resource for graduate students, post-doctoral researchers, and established investigators utilizing lipid-based systems in the fields of cell and molecular biology, drug delivery, and physical chemistry.
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124.950000 USD

Liposomes: Methods and Protocols

Paperback / softback
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This detailed book arrives as there is an increasing need for multiplex biomarker readouts for improved clinical management and to support the development of new drugs by pharmaceutical companies, due to continuous technical developments and new insights into the high complexity of many diseases. Chapters explore the basic technology platforms ...
Multiplex Biomarker Techniques: Methods and Applications
This detailed book arrives as there is an increasing need for multiplex biomarker readouts for improved clinical management and to support the development of new drugs by pharmaceutical companies, due to continuous technical developments and new insights into the high complexity of many diseases. Chapters explore the basic technology platforms being applied in the fields of genomics, proteomics, transcriptomics, metabolomics, and imaging, which are currently the methods of choice in multiplex biomarker research. The book also describes the chief medical areas in which the greatest progress has been made and highlight areas where further resources are required. Written for the highly successful Methods in Molecular Biology series, methodology chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Multiplex Biomarker Techniques: Methods and Applications serves as an ideal resource for a wide variety of researchers interested in these vital multiplex techniques.
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145.950000 USD

Multiplex Biomarker Techniques: Methods and Applications

Paperback / softback
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This is the second edition of a well-received book that reflects the state of the art in cancer medical therapies and their side-effects, including immunotherapy and chemotherapeutic drugs. All chapters have been fully updated to include all the latest progress in drug discovery such as targeted therapies for each cancer ...
Side Effects of Medical Cancer Therapy: Prevention and Treatment
This is the second edition of a well-received book that reflects the state of the art in cancer medical therapies and their side-effects, including immunotherapy and chemotherapeutic drugs. All chapters have been fully updated to include all the latest progress in drug discovery such as targeted therapies for each cancer type. From issues such as preservation of fertility to antiemetic therapy the book provides a very comprehensive overview of the field. The book includes a new chapter on immuno-oncology drugs. Organised by organ system, it lists the toxicity, side-effects and measures of prevention pertaining to each type of drug used in cancer therapy. The most dangerous side-effects are priority so as to alert the reader to their importance. Designed for quick reference in the clinical setting this book is primarily aimed at established medical oncologists but will also appeal to junior doctors, trainees, pharmacists and nurses.
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208.950000 USD

Side Effects of Medical Cancer Therapy: Prevention and Treatment

Hardback
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This unique publication explores diverse themes relating to thrombosis and embolism, from basic research at cell and molecular level to the actual care, prevention, and treatment of diverse categories of patients suffering from such diseases. Chapters cover a variety of topics including thrombosis and embolism in surgical patients, cancer patients, ...
Thrombosis and Embolism: from Research to Clinical Practice: Volume 1
This unique publication explores diverse themes relating to thrombosis and embolism, from basic research at cell and molecular level to the actual care, prevention, and treatment of diverse categories of patients suffering from such diseases. Chapters cover a variety of topics including thrombosis and embolism in surgical patients, cancer patients, pregnant women and children and adolescents, as well as treatment of the conditions by traditional anticoagulants, novel oral anticoagulants, thrombolytic therapy, endovascular treatment and embolectomy. Readers may explore cutting edge research, recommendations from major societies, contemporary guidelines, areas of controversy and directions for ongoing and future research. The book features comprehensive information ranging from molecular mechanisms of diseases to the clinical features, diagnosis, and therapeutic regimens for treating a variety of clinical conditions. It has a broad appeal to scientists and research students as well as busy clinicians engaged in patient care, who will all find something important and useful amongst these carefully selected chapters.
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209.990000 USD

Thrombosis and Embolism: from Research to Clinical Practice: Volume 1

Paperback / softback
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Medicinal Chemistry: Fundaments presents the cycle of the life of drugs, their physico-chemical properties, and consequences that arise in development. The fundamental concepts of Medicinal Chemistry (pharmacophore, prodrugs, Lipinsky rules) are also presented, including discussions on specific concerns of the European Pharmacopeia - the industrialist's bible - its role, and ...
Medicinal Chemistry: Fundamentals
Medicinal Chemistry: Fundaments presents the cycle of the life of drugs, their physico-chemical properties, and consequences that arise in development. The fundamental concepts of Medicinal Chemistry (pharmacophore, prodrugs, Lipinsky rules) are also presented, including discussions on specific concerns of the European Pharmacopeia - the industrialist's bible - its role, and a description of the monographs of active principles.
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170.54 USD

Medicinal Chemistry: Fundamentals

by Roland Barret
Hardback
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This book provides a critical and comprehensive review of the methodologies available for measuring drug adherence in clinical practice, including those relying on emerging technologies. The authors discuss the risk factors of non-adherence and shed light on how to identify patients at risk of poor adherence. Drug therapies in chronic ...
Drug Adherence in Hypertension and Cardiovascular Protection
This book provides a critical and comprehensive review of the methodologies available for measuring drug adherence in clinical practice, including those relying on emerging technologies. The authors discuss the risk factors of non-adherence and shed light on how to identify patients at risk of poor adherence. Drug therapies in chronic diseases rely heavily on the patient's adherence, since drugs that are not taken are ineffective and leave the patient at high risk of developing clinical complications. Given the absence of new drugs for the treatment of hypertension, drug adherence is particularly important in these patients to improve blood pressure control. The book further investigates a new aspect, namely the importance of drug adherence in clinical trials and studies and draws attention to the limits of developing drugs without significant information on drug adherence. Several chapters are dedicated to the importance of adherence in specific forms of hypertension, such as resistant hypertension, dyslipidemia and hypertension associated with cardiovascular risk. As experts confronted with drug adherence in their daily practice, the authors analyse the real effectiveness of several interventions aimed at improving drug adherence and put particular emphasis on the importance of an interdisciplinary approach involving nurses and pharmacists. The volume also includes a careful analysis of the health and economic impact of poor adherence. The book is aimed at physicians, pharmacists, students and all health professionals dealing not only with hypertension or dyslipidemia, but also with chronic asymptomatic diseases such as diabetes, HIV or chronic respiratory diseases.
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135.450000 USD

Drug Adherence in Hypertension and Cardiovascular Protection

Hardback
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Scientific Healing Affirmations
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5.140000 USD

Scientific Healing Affirmations

by Paramahansa Yogananda
Paperback / softback
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