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This book is an international effort to standardize the language, terms, and methods used in ocular toxicology.With over 300 color illustrations this consensus volume provides standards and harmonization for procedures, terminology, and scoring schemes for ocular toxicology. it is essential for industry, pharmaceutical companies, and governmental agencies to help improve ...
Standards for Ocular Toxicology and Inflammation
This book is an international effort to standardize the language, terms, and methods used in ocular toxicology.With over 300 color illustrations this consensus volume provides standards and harmonization for procedures, terminology, and scoring schemes for ocular toxicology. it is essential for industry, pharmaceutical companies, and governmental agencies to help improve the drug development process and to reduce and refine the use of animals in research. Standards for Ocular Toxicology and Inflammation is endorsed by the American College of Veterinary Ophthalmologists.
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178.490000 USD

Standards for Ocular Toxicology and Inflammation

Hardback
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The focus of this book is on how the US FDA will approve biosimilar drugs. The European scene is well developed with specific guidelines that are already in place. However, these guidelines do not apply to the thinking of the FDA in approving these products. The FDA is quite different ...
Biosimilarity: The FDA Perspective
The focus of this book is on how the US FDA will approve biosimilar drugs. The European scene is well developed with specific guidelines that are already in place. However, these guidelines do not apply to the thinking of the FDA in approving these products. The FDA is quite different from other regulatory agencies. With the US providing more than 50% of the worldwide market for these products, every serious manufacturer of biosimilar biological drugs should be targeting US approval of their products. Thus, this book is strictly on FDA approval strategy.
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206.46 USD

Biosimilarity: The FDA Perspective

by Sarfaraz K Niazi
Hardback
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Most biological pathways, physical and neurological properties are highly conserved between humans and Drosophila and nearly 75% of human disease-causing genes have a functional homologue in Drosophila. This volume provides recent advances in Drosophila models for various human diseases, with each chapter providing a review of studies involving Drosophila models, ...
Drosophila Models for Human Diseases
Most biological pathways, physical and neurological properties are highly conserved between humans and Drosophila and nearly 75% of human disease-causing genes have a functional homologue in Drosophila. This volume provides recent advances in Drosophila models for various human diseases, with each chapter providing a review of studies involving Drosophila models, as well as detailed protocols commonly used in laboratories. Starting with a review of Drosophila's value as a highly tractable model organism for studying human diseases, subsequent chapters present Drosophila models for specific human diseases. The book provides a useful resource for all scientists who are starting to use the Drosophila model in their studies, and for researchers working in the pharmaceutical industry and using new screening models to develop new medicines for various diseases.
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188.990000 USD

Drosophila Models for Human Diseases

Hardback
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This work brings together a wealth of data regarding the reference values and factors of variation in biochemical parameters used by camel veterinarians and scientists to determine these animals' nutritional and clinical status. It also explores several technical aspects involved in determining these parameters, sampling procedures, and essential elements in ...
Camel Clinical Biochemistry and Hematology
This work brings together a wealth of data regarding the reference values and factors of variation in biochemical parameters used by camel veterinarians and scientists to determine these animals' nutritional and clinical status. It also explores several technical aspects involved in determining these parameters, sampling procedures, and essential elements in the interpretation of the results. Though many texts are available on small and large ruminants, much less is known about species confined to the marginal zones of tropical and Mediterranean countries, such as camels. This book addresses precisely this research gap, on the one hand by presenting an extensive review of the literature, and on the other by synthesizing the outcomes of the authors' numerous previous works. In veterinary medicine, blood tests to help diagnose diseases in cattle were first proposed nearly a century ago, but were mainly developed in the 1960s, initially at specialized research or veterinary services laboratories, and eventually, with the advent of new equipment and the miniaturization of the analyzers, finding their way into veterinarians' cabinets. Beyond their diagnostic value, veterinary surgeons and zootechnicians also speculated on the potential use of blood tests to evaluate animals' nutritional status. Thus, a whole range of analyses are now proposed to the stakeholders responsible for animal health. Such analyses could help to define a metabolic profile, which would offer a valuable decision-making tool for experts and researchers alike.
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209.990000 USD

Camel Clinical Biochemistry and Hematology

by Mohammed Bengoumi, Bernard Faye
Hardback
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Since the publication of the first edition in 2000, there has been an explosive growth of literature in biopharmaceutical research and development of new medicines. This encyclopedia (1) provides a comprehensive and unified presentation of designs and analyses used at different stages of the drug development process, (2) gives a ...
Encyclopedia of Biopharmaceutical Statistics - Four Volume Set
Since the publication of the first edition in 2000, there has been an explosive growth of literature in biopharmaceutical research and development of new medicines. This encyclopedia (1) provides a comprehensive and unified presentation of designs and analyses used at different stages of the drug development process, (2) gives a well-balanced summary of current regulatory requirements, and (3) describes recently developed statistical methods in the pharmaceutical sciences. Features of the Fourth Edition: 1. 78 new and revised entries have been added for a total of 308 chapters and a fourth volume has been added to encompass the increased number of chapters. 2. Revised and updated entries reflect changes and recent developments in regulatory requirements for the drug review/approval process and statistical designs and methodologies. 3. Additional topics include multiple-stage adaptive trial design in clinical research, translational medicine, design and analysis of biosimilar drug development, big data analytics, and real world evidence for clinical research and development. 4. A table of contents organized by stages of biopharmaceutical development provides easy access to relevant topics. About the Editor: Shein-Chung Chow, Ph.D. is currently an Associate Director, Office of Biostatistics, U.S. Food and Drug Administration (FDA). Dr. Chow is an Adjunct Professor at Duke University School of Medicine, as well as Adjunct Professor at Duke-NUS, Singapore and North Carolina State University. Dr. Chow is the Editor-in-Chief of the Journal of Biopharmaceutical Statistics and the Chapman & Hall/CRC Biostatistics Book Series and the author of 28 books and over 300 methodology papers. He was elected Fellow of the American Statistical Association in 1995.
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1578.29 USD

Encyclopedia of Biopharmaceutical Statistics - Four Volume Set

Hardback
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The BNF for Children (BNFC) 2018-2019 provides essential practical information to all healthcare professionals involved in the prescribing, dispensing, monitoring and administration of medicines to children. It addresses a significant knowledge gap in many areas of paediatric practice by providing practical information on the use of medicines in children of ...
BNF for Children (BNFC) 2018-2019
The BNF for Children (BNFC) 2018-2019 provides essential practical information to all healthcare professionals involved in the prescribing, dispensing, monitoring and administration of medicines to children. It addresses a significant knowledge gap in many areas of paediatric practice by providing practical information on the use of medicines in children of all ages from birth to adolescence. Recommendations in the BNFC have been constructed on the basis of authoritative sources, emerging evidence and best practice guidelines. The content has been carefully validated by a network of paediatric experts and the process is overseen by a paediatric formulary committee. The BNF for Children 2018-2019 has been revised and revalidated to reflect changes in product availability, emerging safety concerns and shifts in clinical practice.
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98.11 USD

BNF for Children (BNFC) 2018-2019

Paperback / softback
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The field of molecular medicine covers the medical interventions targeting molecular structures and mechanisms that are involved in disease progression. In cancer, several molecular mechanisms have been shown to impact its progression, aggressiveness and chemoresistance. Increasing evidence demonstrates the role of nanotechnology and outcome of molecular therapy. Several books have ...
Molecular Medicines for Cancer: Concepts and Applications of Nanotechnology
The field of molecular medicine covers the medical interventions targeting molecular structures and mechanisms that are involved in disease progression. In cancer, several molecular mechanisms have been shown to impact its progression, aggressiveness and chemoresistance. Increasing evidence demonstrates the role of nanotechnology and outcome of molecular therapy. Several books have discussed molecular biology and mechanisms involved in cancer, but this text gives an account of molecular therapeutics in cancer relating to advancements of nanotechnology. It provides a description of the multidisciplinary field of molecular medicines and its targeted delivery to cancer using nanotechnology.
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307.12 USD

Molecular Medicines for Cancer: Concepts and Applications of Nanotechnology

Hardback
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This book discusses various fundamental aspects of polysaccharide based nano-biocarrier drug delivery systems and its application in the delivery of small molecules, proteins, peptides, oligonucleotides and genes. It also discusses advances in drug delivery systems in treatment of cancer, cardiovascular, pulmonary, and infectious diseases.
Polysaccharide based Nano-Biocarrier in Drug Delivery
This book discusses various fundamental aspects of polysaccharide based nano-biocarrier drug delivery systems and its application in the delivery of small molecules, proteins, peptides, oligonucleotides and genes. It also discusses advances in drug delivery systems in treatment of cancer, cardiovascular, pulmonary, and infectious diseases.
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264.47 USD

Polysaccharide based Nano-Biocarrier in Drug Delivery

Hardback
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Compiled with the advice of clinical experts and continually updated to reflect the latest evidence from credible sources worldwide, the new edition of the British National Formulary 76 (BNF) provides up-to-date guidance on prescribing, dispensing, and administering medicines. Access to the latest edition of the BNF is vital for healthcare ...
BNF 76 (British National Formulary) September 2018
Compiled with the advice of clinical experts and continually updated to reflect the latest evidence from credible sources worldwide, the new edition of the British National Formulary 76 (BNF) provides up-to-date guidance on prescribing, dispensing, and administering medicines. Access to the latest edition of the BNF is vital for healthcare professionals, as it reflects current best practice as well as legal and professional guidelines relating to the uses of medicines.NICE has accredited the editorial process used by the British National Formulary to produce its resources.
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98.11 USD

BNF 76 (British National Formulary) September 2018

Paperback / softback
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This book focuses on analytical similarity assessment in biosimilar product development following the FDA's recommended stepwise approach for obtaining totality-of-the-evidence for approval of biosimilar products. It covers concepts such as the tiered approach for assessment of similarity of critical quality attributes in the manufacturing process of biosimilar products, models/methods like ...
Analytical Similarity Assessment in Biosimilar Product Development
This book focuses on analytical similarity assessment in biosimilar product development following the FDA's recommended stepwise approach for obtaining totality-of-the-evidence for approval of biosimilar products. It covers concepts such as the tiered approach for assessment of similarity of critical quality attributes in the manufacturing process of biosimilar products, models/methods like the statistical model for classification of critical quality attributes, equivalence tests for critical quality attributes in Tier 1 and the corresponding sample size requirements, current issues, and recent developments in analytical similarity assessment.
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221.81 USD

Analytical Similarity Assessment in Biosimilar Product Development

by Shein-Chung Chow
Hardback
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Biology and Ecology of Pharmaceutical Marine Sponges is the first comprehensive book of its kind written by scientists from both the Marine Biology and Pharmacy disciplines to fill the long-felt need for a marine natural products book devoted exclusively to sponges. Sponges are the most primitive multicelled animals that have ...
Biology and Ecology of Pharmaceutical Marine Sponges
Biology and Ecology of Pharmaceutical Marine Sponges is the first comprehensive book of its kind written by scientists from both the Marine Biology and Pharmacy disciplines to fill the long-felt need for a marine natural products book devoted exclusively to sponges. Sponges are the most primitive multicelled animals that have existed for 700 - 800 million years. Despite their wide range of functional roles, not much is known about them. Marine sponges are responsible for more than 5,300 pharmaceutical products and some species have the potential to provide future drugs to prevent and treat important medical conditions such as cancer, a range of viral diseases, malaria, and inflammatory diseases. Nucleosides derived from sponges were the basis for the synthesis of Ara-C, the first marine-derived anticancer agent, currently used in the routine treatment of patients with leukemia and lymphoma. Marine sponges are the potential sources of many unique metabolites with anticancer,anti-inflammatory, antibiotic, antiviral, antimalarial, and immune or neurosuppressive properties. Although many bioactives have been discovered in marine sponges, only a few of these compounds have been commercialized. This book hopes to change that, providing the taxonomy, common name, global distribution, habitat, diagnostic features and pharmaceutical compounds (along with their chemical structure and activities) of 450 species of marine sponges, accompanied by high-quality illustrations. The book should be a standard reference for students, researchers and teachers of disciplines such as Fisheries Science, Marine Biology, Biochemistry, Biotechnology and Pharmacy and a valuable guide for pharmaceutical companies involved in the development of new drugs from marine sponges.
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324.19 USD

Biology and Ecology of Pharmaceutical Marine Sponges

by Anbu Jeba Sunilson, Santhanam Ramesh, Ramasamy Santhanam
Hardback
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Drug Delivery Nanosystems for Biomedical Application reviews some of the most challenging nanosystems with different routes of delivery that are useful for specific drugs, from both efficacy and bioavailability points-of-view. The chapters explore how this area is developing, the present state of the field, and future developments, in particular, inorganic, ...
Drug Delivery Nanosystems for Biomedical Applications
Drug Delivery Nanosystems for Biomedical Application reviews some of the most challenging nanosystems with different routes of delivery that are useful for specific drugs, from both efficacy and bioavailability points-of-view. The chapters explore how this area is developing, the present state of the field, and future developments, in particular, inorganic, metallic, polymeric, composite and lipid nanosystems and their possible evolution to clinical applications. The book is a valuable research reference for both researchers and industrial partners who are not only interested in learning about this area, but also want to gain insights on how to move towards translational research.
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189.000000 USD

Drug Delivery Nanosystems for Biomedical Applications

by Sharma
Hardback
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This book presents an extensive study on the effectiveness of recent regulations on pharmaceutical prices in India, exploring the weaknesses in the design and implementation of pharmaceutical price controls and investigating what can be done to fix the broken system. In addition, it examines the extent to which essential medicines ...
Regulating Pharmaceutical Prices in India: Policy Design, Implementation and Compliance
This book presents an extensive study on the effectiveness of recent regulations on pharmaceutical prices in India, exploring the weaknesses in the design and implementation of pharmaceutical price controls and investigating what can be done to fix the broken system. In addition, it examines the extent to which essential medicines are actually made affordable by price controls. The book argues that companies make the pharmaceutical price control regime largely ineffective by coordinating to increase pre-regulation prices; by diversifying horizontally away from the regulated markets and increasing prices in the unregulated markets; by manipulating trade margins; and by refusing to comply with the regulation because the penalties remains negligible. The book draws on extensive empirical research involving India's 2013 Drug Price Control Order and widely-used medicines such as paracetamol and metformin to illustrate how firms have weakened regulation. It argues that the regulatory regime can be strengthened by using systematic analysis of product- and region-level data in the Indian pharmaceutical industry, and by screening for the strategies that firms currently employ to circumvent regulation. In closing, it discusses recent efforts to strengthen the implementation of price controls in India and expanding the scope of price controls to medical devices.
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146.990000 USD

Regulating Pharmaceutical Prices in India: Policy Design, Implementation and Compliance

by Ajay Bhaskarabhatla
Hardback
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Medicines, Ethics and Practice: The professional guide for pharmacists is the Royal Pharmaceutical Society's established professional guide for pharmacists. This 42nd edition is a revised practical resource which helps pharmacists practice confidently and professionally. It embeds professionalism at the heart of decision-making processes and provides essential information, supporting the pharmacist ...
Medicines, Ethics and Practice 2018: The professional guide for pharmacists
Medicines, Ethics and Practice: The professional guide for pharmacists is the Royal Pharmaceutical Society's established professional guide for pharmacists. This 42nd edition is a revised practical resource which helps pharmacists practice confidently and professionally. It embeds professionalism at the heart of decision-making processes and provides essential information, supporting the pharmacist in their day-to-day practice.
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93.85 USD

Medicines, Ethics and Practice 2018: The professional guide for pharmacists

by Royal Pharmaceutical Society
Paperback / softback
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This book sheds new light on the diagnosis and treatment of Heart Failure in adult patients with congenital heart disease. This is a rapidly growing clinical issue for this group of patients and the clinical teams caring for them. The book highlights the major clinical dilemmas in diagnosing heart failure ...
Heart Failure in Adult Congenital Heart Disease
This book sheds new light on the diagnosis and treatment of Heart Failure in adult patients with congenital heart disease. This is a rapidly growing clinical issue for this group of patients and the clinical teams caring for them. The book highlights the major clinical dilemmas in diagnosing heart failure in patients with a lifelong cardiac condition and describes in details the utility of biomarkers, complex imaging and functional tests, e.g. the cardiopulmonary exercise testing. A step-wise approach to treatment is described from drug therapy through to devices and transplantation. As such, the book offers an essential guide for cardiologists and cardiac surgeons looking to optimize the management of patients with delicate physiology and complex disease.
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135.450000 USD

Heart Failure in Adult Congenital Heart Disease

Hardback
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Natural, popular, and inexpensive, apple cider vinegar is the latest health trend. Learn more about its powers with this attractive and easy-to-use illustrated guide--complete with recipes! We all know that apple cider vinegar is a useful addition to the pantry and a tasty ingredient in cooking. But it can do ...
Apple Cider Vinegar Handbook
Natural, popular, and inexpensive, apple cider vinegar is the latest health trend. Learn more about its powers with this attractive and easy-to-use illustrated guide--complete with recipes! We all know that apple cider vinegar is a useful addition to the pantry and a tasty ingredient in cooking. But it can do more than just add flavor. With the potential to cure an upset stomach, treat a sore throat, aid weight loss, and more, apple cider vinegar is one of today's handiest all-natural remedies. The Apple Cider Vinegar Handbook shows you why this inexpensive liquid is a must-have in your home and how to use it to achieve optimum health.
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22.17 USD

Apple Cider Vinegar Handbook

by Amy Leigh Mercree
Paperback / softback
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The cyclic purine nucleotides 3',5'-cAMP and 3',5'-cGMP are well-established second messengers. cGMP has recently been covered in a volume of the Handbook of Experimental Pharmacology (volume 191). In addition to 3',5'-cAMP and 3',5'-cGMP, so-called non-canonical cyclic nucleotides exist. These comprise the cyclic pyrimidine nucleotides 3',5'-cCMP and 3',5'-cUMP, the purine nucleotide ...
Non-canonical Cyclic Nucleotides
The cyclic purine nucleotides 3',5'-cAMP and 3',5'-cGMP are well-established second messengers. cGMP has recently been covered in a volume of the Handbook of Experimental Pharmacology (volume 191). In addition to 3',5'-cAMP and 3',5'-cGMP, so-called non-canonical cyclic nucleotides exist. These comprise the cyclic pyrimidine nucleotides 3',5'-cCMP and 3',5'-cUMP, the purine nucleotide 3',5'-cIMP, the 2',3'-nucleoside monophosphates and cyclic dinucleotides. In this volume of the Handbook of Pharmacology, word-leading experts in the field summarize our current knowledge on these non-canonical cyclic nucleotides, discuss open questions, future research directions and the pharmacotherapeutic implications. Special emphasis will be given to the emerging roles of 3',5'-cCMP and 3',5'-cUMP as second messengers with regard to generators, effectors, biological functions, inactivation and bacterial toxins. The role of 3',5'-cIMP as potential second messenger will also be critically discussed. Furthermore, we will consider transport of cyclic nucleotides and their potential role as first messengers. The role of the cyclic dinucleotide cGAMP in the immune system will covered, too. Lastly, the book will present important methodological aspects ranging from mass-spectrometric methods for cyclic nucleotide detection to the synthesis of nucleotide analogs as experimental tools and holistic methods for analysis of cyclic nucleotide effects.
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367.490000 USD

Non-canonical Cyclic Nucleotides

Paperback / softback
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This book starts with a general introduction to phytochemistry, followed by chapters on plant constituents, their origins and chemistry, but also discussing animal-, microorganism- and mineral-based drugs. Further chapters cover vitamins, food additives and excipients as well as xenobiotics and poisons. The book also explores the herbal approach to disease ...
Therapeutic Use of Medicinal Plants and their Extracts: Volume 2: Phytochemistry and Bioactive Compounds
This book starts with a general introduction to phytochemistry, followed by chapters on plant constituents, their origins and chemistry, but also discussing animal-, microorganism- and mineral-based drugs. Further chapters cover vitamins, food additives and excipients as well as xenobiotics and poisons. The book also explores the herbal approach to disease management and molecular pharmacognosy and introduces methods of qualitative and quantitative analysis of plant constituents. Phytochemicals are classified as primary (e.g. carbohydrates, lipids, amino acid derivations, etc.) or secondary (e.g. alkaloids, terpenes and terpenoids, phenolic compounds, glycosides, etc.) metabolites according to their metabolic route of origin, chemical structure and function. A wide variety of primary and secondary phytochemicals are present in medicinal plants, some of which are active phytomedicines and some of which are pharmaceutical excipients.
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262.490000 USD

Therapeutic Use of Medicinal Plants and their Extracts: Volume 2: Phytochemistry and Bioactive Compounds

by A.N.M. Alamgir
Hardback
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This is the second edition of a well-received book that reflects the state of the art in cancer medical therapies and their side-effects, including immunotherapy and chemotherapeutic drugs. All chapters have been fully updated to include all the latest progress in drug discovery such as targeted therapies for each cancer ...
Side Effects of Medical Cancer Therapy: Prevention and Treatment
This is the second edition of a well-received book that reflects the state of the art in cancer medical therapies and their side-effects, including immunotherapy and chemotherapeutic drugs. All chapters have been fully updated to include all the latest progress in drug discovery such as targeted therapies for each cancer type. From issues such as preservation of fertility to antiemetic therapy the book provides a very comprehensive overview of the field. The book includes a new chapter on immuno-oncology drugs. Organised by organ system, it lists the toxicity, side-effects and measures of prevention pertaining to each type of drug used in cancer therapy. The most dangerous side-effects are priority so as to alert the reader to their importance. Designed for quick reference in the clinical setting this book is primarily aimed at established medical oncologists but will also appeal to junior doctors, trainees, pharmacists and nurses.
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208.950000 USD

Side Effects of Medical Cancer Therapy: Prevention and Treatment

Hardback
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This unique publication explores diverse themes relating to thrombosis and embolism, from basic research at cell and molecular level to the actual care, prevention, and treatment of diverse categories of patients suffering from such diseases. Chapters cover a variety of topics including thrombosis and embolism in surgical patients, cancer patients, ...
Thrombosis and Embolism: from Research to Clinical Practice: Volume 1
This unique publication explores diverse themes relating to thrombosis and embolism, from basic research at cell and molecular level to the actual care, prevention, and treatment of diverse categories of patients suffering from such diseases. Chapters cover a variety of topics including thrombosis and embolism in surgical patients, cancer patients, pregnant women and children and adolescents, as well as treatment of the conditions by traditional anticoagulants, novel oral anticoagulants, thrombolytic therapy, endovascular treatment and embolectomy. Readers may explore cutting edge research, recommendations from major societies, contemporary guidelines, areas of controversy and directions for ongoing and future research. The book features comprehensive information ranging from molecular mechanisms of diseases to the clinical features, diagnosis, and therapeutic regimens for treating a variety of clinical conditions. It has a broad appeal to scientists and research students as well as busy clinicians engaged in patient care, who will all find something important and useful amongst these carefully selected chapters.
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209.990000 USD

Thrombosis and Embolism: from Research to Clinical Practice: Volume 1

Paperback / softback
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Medicinal Chemistry: Fundaments presents the cycle of the life of drugs, their physico-chemical properties, and consequences that arise in development. The fundamental concepts of Medicinal Chemistry (pharmacophore, prodrugs, Lipinsky rules) are also presented, including discussions on specific concerns of the European Pharmacopeia - the industrialist's bible - its role, and ...
Medicinal Chemistry: Fundamentals
Medicinal Chemistry: Fundaments presents the cycle of the life of drugs, their physico-chemical properties, and consequences that arise in development. The fundamental concepts of Medicinal Chemistry (pharmacophore, prodrugs, Lipinsky rules) are also presented, including discussions on specific concerns of the European Pharmacopeia - the industrialist's bible - its role, and a description of the monographs of active principles.
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170.54 USD

Medicinal Chemistry: Fundamentals

by Roland Barret
Hardback
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This detailed volume brings together a diverse collection of stem cell-derived model-based toxicity assays, from those routinely used to those deemed to have considerable potential. With a focus on differentiated tissues, the chapters explore numerous cardiotoxicity applications as well as coverage of neurotoxicity, hepatotoxicity, and more. Written for the Methods ...
Stem Cell-Derived Models in Toxicology
This detailed volume brings together a diverse collection of stem cell-derived model-based toxicity assays, from those routinely used to those deemed to have considerable potential. With a focus on differentiated tissues, the chapters explore numerous cardiotoxicity applications as well as coverage of neurotoxicity, hepatotoxicity, and more. Written for the Methods in Pharmacology and Toxicology series, the contents of this book aim to enable adoption of these protocols in laboratories that are interested in entering the field as well as to facilitate the transfer of best practices between laboratories that are already actively pursuing these technologies. Authoritative and cutting-edge, Stem Cell-Derived Models in Toxicology serves as a vital resource for researchers aiming to improve risk assessment in drug discovery and design.
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145.950000 USD

Stem Cell-Derived Models in Toxicology

Paperback / softback
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Current cancer therapies are focused on three general strategies: modifying intrinsic radiosensitivity via molecular targeting, manipulating microenvironmental factors to enhance tumor susceptibility to radiation, and improving delivery of radiation to critical tumor locations while sparing normal tissues. The goal of this volume is to describe a number of promising approaches ...
Increasing the Therapeutic Ratio of Radiotherapy
Current cancer therapies are focused on three general strategies: modifying intrinsic radiosensitivity via molecular targeting, manipulating microenvironmental factors to enhance tumor susceptibility to radiation, and improving delivery of radiation to critical tumor locations while sparing normal tissues. The goal of this volume is to describe a number of promising approaches corresponding to each strategy. In general, research in radiation oncology tends to be siloed into fundamental biology, physics or treatment delivery. The strategies for improving therapeutic ratio encompassed in this book will involve each of these components of radiation oncology. Thus, they will illustrate the variety of disparate approaches available for potentially improving the efficacy of radiotherapy, which may then stimulate discussion across disciplines and foster further translational investigations. Although a goal of each chapter will be to highlight advances within an approach, of equal importance will be the delineation of barriers to successful clinical application and how to overcome or minimize such impediments. Along these lines, because therapeutic ratio incorporates both tumor and normal tissue radio response, a point of emphasis will be the mechanistic rationale for selectively modifying tumor (sensitization) or normal cells (protection). Finally, whereas the literature is replete with studies describing potential targets/strategies for increasing the therapeutic ratio for radiotherapy, this book will focus on those supported by in vivo data consistent with impending translational application along with those that are already being evaluated in the clinic.
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230.990000 USD

Increasing the Therapeutic Ratio of Radiotherapy

Paperback / softback
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This thorough volume delves into antiepileptic drug discovery with a comprehensive collection of innovative approaches for the development of antiepileptic therapies, focusing on novel molecular targets for antiepileptic drugs, computer-aided approaches for the identification of new drug candidates, and therapeutic strategies to overcome refractory epilepsy. The last section illustrates the ...
Antiepileptic Drug Discovery: Novel Approaches
This thorough volume delves into antiepileptic drug discovery with a comprehensive collection of innovative approaches for the development of antiepileptic therapies, focusing on novel molecular targets for antiepileptic drugs, computer-aided approaches for the identification of new drug candidates, and therapeutic strategies to overcome refractory epilepsy. The last section illustrates the potential benefits that network pharmacology and rational drug repurposing could bring to the antiepileptic drug discovery community. Written for the Methods in Pharmacology and Toxicology series, chapters include the kind of detailed description and implementation advice to ensure results in the laboratory. Authoritative and practical, Antiepileptic Drug Discovery: Novel Approaches aims to provide medicinal chemists, pharmacologists, and other researchers with the tools need to further explore the study of pharmacoresistant epilepsy and the discovery of new antiepileptic drugs.
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145.950000 USD

Antiepileptic Drug Discovery: Novel Approaches

Paperback / softback
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Winner of BMA Medical Book Award, Highly Commended in Public Health Written for medical professionals, this book provides a concise reference with clear guidelines on how to manage both the victims of chemical agent exposure and the site of the incident. David Baker considers the nature and basic science of ...
Toxic Trauma: A Basic Clinical Guide
Winner of BMA Medical Book Award, Highly Commended in Public Health Written for medical professionals, this book provides a concise reference with clear guidelines on how to manage both the victims of chemical agent exposure and the site of the incident. David Baker considers the nature and basic science of the hazards faced as well as the practical management of persons exposed to chemicals and toxins. Praise for the first edition Toxic Trauma is a welcome addition to the literature. . . . Although written for clinicians, the book contains chapters that should be read by administrators and other health care professionals to ensure they understand and can inform the public in a balanced manner about the logistic considerations, and widespread consequences across systems when an event does occur. Any healthcare library should consider this book an essential text. --Michael Nurok, American Journal of Disaster Medicine This book excels as a reference for those interested in learning about and designing systems to better handle toxic trauma. --Michael D. Zwank, Doody's Book Reviews
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125.990000 USD

Toxic Trauma: A Basic Clinical Guide

by David J. Baker
Paperback / softback
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This volume explores techniques that are currently used to understand solid target-specific models in computational toxicology. The chapters are divided into four sections and discuss topics such as molecular descriptors, QSAR and read-across; molecular and data modeling techniques to comply with both scientific and regulatory sides; computational toxicology in drug ...
Computational Toxicology: Methods and Protocols
This volume explores techniques that are currently used to understand solid target-specific models in computational toxicology. The chapters are divided into four sections and discuss topics such as molecular descriptors, QSAR and read-across; molecular and data modeling techniques to comply with both scientific and regulatory sides; computational toxicology in drug discovery; and strategies on how to predict various human-health toxicology endpoints. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the methods and software tools used, step-by-step, readily reproducible computational protocols, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and cutting-edge, Computational Toxicology: Methods and Protocols is a valuable resource for researchers who are interested in learning more about this expanding field.
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230.990000 USD

Computational Toxicology: Methods and Protocols

Hardback
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This Brief takes the reader on a chemical journey by following the history for over two centuries of how an opiate became an opioid, thus spawning an empire and a series of crises. These imperfect resemblances of alkaloids are both natural and synthetic substances that, particularly in America, are continually ...
A Time-Release History of the Opioid Epidemic
This Brief takes the reader on a chemical journey by following the history for over two centuries of how an opiate became an opioid, thus spawning an empire and a series of crises. These imperfect resemblances of alkaloids are both natural and synthetic substances that, particularly in America, are continually part of a growing concern about overuse. This seemed an inviting prospect for those in pain, but as the ubiquitous media coverage continues to lay bare, the levels of abuse point to the fact that perhaps an epidemic is upon us, if not a culture war. Seeking answers to how and why this addiction crisis transpired over two hundred years of long development, this Brief examines the role that the chemistry laboratory played in turning patients into consumers. By utilizing a host of diverse sources, this Brief seeks to trace the design and the production of opioids and their antecedents over the past two centuries. From the isolation and development of the first alkaloids with morphine that relieved pain within the home and on the battlefield, to the widespread use of nostrums and the addiction crisis that ensued, to the dissemination of drugs by what became known as Big Pharma after the World Wars; and finally, to competition from home-made pharmaceuticals, the progenitor was always, in some form, a type of chemistry lab. At times, the laboratory pressed science to think deeply about society's maladies, such as curing disease and alleviating pain, in order to look for new opportunities in the name of progress. Despite the best intentions opioids have created a paradox of pain as they were manipulated by creating relief with synthetic precision and influencing a dystopian vision. Thus, influence came in many forms, from governments, from the medical community, and from the entrepreneurial aspirations of the general populace. For better, but mostly for worse, all played a role in changing forever the trajectory of what started with the isolation of a compound in Germany. Combining chemistry and history in a rousing new long-form narrative that even broadens the definition of a laboratory, the origins and future of this complicated topic are carefully examined.
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73.490000 USD

A Time-Release History of the Opioid Epidemic

by Steven M. Rooney, J.N. Campbell
Paperback / softback
Book cover image
Today's challenge, especially for many newcomers to the regulated industry, is not necessarily to gather regulatory information, but to know how to interpret and apply it. The ability to discern what is important from what is not, and to interpret regulatory documents correctly, provides a valuable competitive advantage to any ...
An Overview of FDA Regulated Products: From Drugs and Cosmetics to Food and Tobacco
Today's challenge, especially for many newcomers to the regulated industry, is not necessarily to gather regulatory information, but to know how to interpret and apply it. The ability to discern what is important from what is not, and to interpret regulatory documents correctly, provides a valuable competitive advantage to any newcomer or established professional in this field. An Overview of FDA Regulated Products: From Drugs and Medical Devices to Food and Tobacco provides a valuable summary of the key information to unveil the meaning of critical, and often complex, regulatory concepts. Concise and easy to read with practical explanations, key points, summaries and case studies, this book highlights the regulatory processes involved in bringing an FDA regulated product from research and development to approval and market. Although the primary focus will be on the US system, this book also features global perspectives where appropriate. A valuable resource for students, professors and professionals, An Overview of FDA Regulated Products illustrates the most important elements and concepts so that the reader can focus on the critical issues and make the necessary connections to be successful.
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104.950000 USD

An Overview of FDA Regulated Products: From Drugs and Cosmetics to Food and Tobacco

Paperback
Book cover image
This book presents a systematic overview of the most relevant nanomaterials and their respective intrinsic properties that have been highly explored by the scientific community and pharmaceutical companies in several different modalities for cancer therapy and bioimaging. The chapters explore the synergistic effects provided by the different nanostructured materials and ...
Nanooncology: Engineering nanomaterials for cancer therapy and diagnosis
This book presents a systematic overview of the most relevant nanomaterials and their respective intrinsic properties that have been highly explored by the scientific community and pharmaceutical companies in several different modalities for cancer therapy and bioimaging. The chapters explore the synergistic effects provided by the different nanostructured materials and highlight the main in vitro and in vivo therapeutic achievements on cancer. This work also provides relevant discussion about the recent progresses and future challenges that nanotechnology faces on the conception of more efficient nanoformulations against primary tumors, circulating cancer cells and metastases.
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209.990000 USD

Nanooncology: Engineering nanomaterials for cancer therapy and diagnosis

Hardback
Book cover image
Bacterial diarrheal diseases remain an important leading cause of preventable death, especially among children under five in developing countries. In the American continent, diarrheal disease and other health complications caused by Escherichia coli constitute a major public health problem, and, therefore, several research groups have dedicated their effort to understand ...
Escherichia coli in the Americas
Bacterial diarrheal diseases remain an important leading cause of preventable death, especially among children under five in developing countries. In the American continent, diarrheal disease and other health complications caused by Escherichia coli constitute a major public health problem, and, therefore, several research groups have dedicated their effort to understand this pathogen and provide feasible solutions to prevent, treat and reduce E. coli infections. The Latin American Coalition for Escherichia coli Research (LACER) was created as a multidisciplinary network of international research groups working with E. coli with the ultimate goal of advancing understanding of E. coli, and to prepare the next generation of American E. coli investigators. As such, this book compiles the knowledge of these investigators about E. coli, a commensal bacteria living inside its host, and a pathogen causing disease in animals and humans. Escherichia coli in the Americas contains a series of 15 chapters written by experts, covering basic concepts regarding the different categories of E. coli, including their environmental niche, virulence mechanisms, host reservoir, and disease outcomes, as well as diagnosis, vaccine development and treatment. This book's target audience include trainees and students learning about the basic and clinical aspects of E. coli pathogenesis, as well as experts around the globe who wish to learn more about this pathogen and the public health impact this bacteria has in America.
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230.990000 USD

Escherichia coli in the Americas

Paperback / softback
Page 1 of 40