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This comprehensive volume discusses in vitro laboratory development of insulin-producing cells. It encompasses multiple aspects of islet biology-from embryonic development and stem cell differentiation to clinical studies in islet transplantation, regulation of islet beta-cell regeneration, pancreatic progenitors, mathematical modelling of islet development, epigenetic regulation, and much more. The chapter authors ...
Pancreatic Islet Biology
This comprehensive volume discusses in vitro laboratory development of insulin-producing cells. It encompasses multiple aspects of islet biology-from embryonic development and stem cell differentiation to clinical studies in islet transplantation, regulation of islet beta-cell regeneration, pancreatic progenitors, mathematical modelling of islet development, epigenetic regulation, and much more. The chapter authors represent leading laboratories from around the world who contribute their international perspectives and global expertise. Collectively, they provide the reader with a concise yet detailed knowledge of processes and current developments in islet regenerative biology. Pancreatic Islet Biology, part of the Stem Cell Biology and Regenerative Medicine series, is essential reading for researchers and clinicians in stem cells or endocrinology, especially those focusing on diabetes.
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230.990000 USD

Pancreatic Islet Biology

Paperback / softback
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Comprised of cases presenting diverse clinical scenarios involving pituitary tumors and related conditions, this concise, practical casebook provides clinical endocrinologists with the best real-world strategies to properly diagnose and treat the various presentations and symptoms they may encounter in daily practice. Discussing macroprolactinoma, non-functioning adenoma, TSH-secreting adenoma, Cushing's disease and ...
Pituitary Tumors: A Clinical Casebook
Comprised of cases presenting diverse clinical scenarios involving pituitary tumors and related conditions, this concise, practical casebook provides clinical endocrinologists with the best real-world strategies to properly diagnose and treat the various presentations and symptoms they may encounter in daily practice. Discussing macroprolactinoma, non-functioning adenoma, TSH-secreting adenoma, Cushing's disease and acromegaly, each chapter is a case that provides a unique clinical presentation of a patient's symptoms and clinical findings, diagnostic work-up and the thought process involved in navigating the treatment options, as well as the supporting evidence. Cases included illustrate different types of tumors, related disorders and special situations and considerations, in addition to various management strategies, complications and outcomes, with helpful clinical pearls and pitfalls. Pragmatic and reader-friendly, Pituitary Tumors: A Clinical Casebook is written by experts in the field and is designed to facilitate and guide endocrinologists in the sometimes challenging decision-making process by presenting real case scenarios that span the spectrum of pituitary tumor presentations and treatment options.
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89.240000 USD

Pituitary Tumors: A Clinical Casebook

Paperback / softback
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This book provides comprehensive information on continuous glucose monitoring (CGM). The first section focuses on the fundamentals of CGM technology, including the principles of CGM, accuracy assessment, operation procedure, management processes, the picture-interpretation methodology, the clinical value of CGM parameters, reference values, clinical applications of CGM report and management systems, ...
Continuous Glucose Monitoring
This book provides comprehensive information on continuous glucose monitoring (CGM). The first section focuses on the fundamentals of CGM technology, including the principles of CGM, accuracy assessment, operation procedure, management processes, the picture-interpretation methodology, the clinical value of CGM parameters, reference values, clinical applications of CGM report and management systems, and clinical indications. In turn, the second section describes the clinical application of CGM, including assessing blood glucose fluctuation and hypoglycemic effects, detecting hypoglycemia and identifying fasting hyperglycemia. It also describes the role of CGM in connection with specific diseases, such as fulminant type 1 diabetes, gestational diabetes mellitus, steroid diabetes, and insulinoma. The closing chapter outlines the future of CGM. In addition, the book presents typical cases and analyses of nearly a hundred typical monitoring maps. As such, it offers diabetic health care doctors a valuable reference guide to the clinical application of and scientific research on CGM.
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224.37 USD

Continuous Glucose Monitoring

Hardback
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Most biological pathways, physical and neurological properties are highly conserved between humans and Drosophila and nearly 75% of human disease-causing genes have a functional homologue in Drosophila. This volume provides recent advances in Drosophila models for various human diseases, with each chapter providing a review of studies involving Drosophila models, ...
Drosophila Models for Human Diseases
Most biological pathways, physical and neurological properties are highly conserved between humans and Drosophila and nearly 75% of human disease-causing genes have a functional homologue in Drosophila. This volume provides recent advances in Drosophila models for various human diseases, with each chapter providing a review of studies involving Drosophila models, as well as detailed protocols commonly used in laboratories. Starting with a review of Drosophila's value as a highly tractable model organism for studying human diseases, subsequent chapters present Drosophila models for specific human diseases. The book provides a useful resource for all scientists who are starting to use the Drosophila model in their studies, and for researchers working in the pharmaceutical industry and using new screening models to develop new medicines for various diseases.
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188.990000 USD

Drosophila Models for Human Diseases

Hardback
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Since the 1970s, there has been much discussion about the glucoreceptor and substrate site and which of these two is the dominant theory, but new findings on the glucose-sensing receptor have now shed new light on the glucoreceptor theory. This volume reviews recent advances concerning the glucose-sensing receptor in pancreatic ...
Glucose-sensing Receptor in Pancreatic Beta-cells
Since the 1970s, there has been much discussion about the glucoreceptor and substrate site and which of these two is the dominant theory, but new findings on the glucose-sensing receptor have now shed new light on the glucoreceptor theory. This volume reviews recent advances concerning the glucose-sensing receptor in pancreatic beta-cells. The history of research into pancreatic beta-cells is long and complex; accordingly, the first chapters present the history of this field and explain the hypothesis of insulin secretion mechanisms: glucoreceptor theory . Subsequent chapters examine the function and activity of the glucose-sensing receptor in pancreatic beta-cells, such as identification, channel pathway, receptor signal and physiological role. Readers will gain a thorough understanding of the glucose-sensing receptor and glucose metabolism in pancreatic beta-cells, new insights into the pathophysiology of diabetes, and learn about new targets for the treatment of diabetes.
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167.990000 USD

Glucose-sensing Receptor in Pancreatic Beta-cells

Hardback
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'I believe it is an ethical imperative for all clinicians who treat women in menopause or women with breast cancer to alert their patients to this book' Michael Baum, MD, Professor Emeritus of Surgery and visiting professor of Medical Humanities, University College London 'A thorough, careful and unbiased assessment . ...
Oestrogen Matters: Why Taking Hormones in Menopause Improves Women's Well-Being, Lengthens Their Lives-and Doesn't Raise the Risk of Breast Cancer
'I believe it is an ethical imperative for all clinicians who treat women in menopause or women with breast cancer to alert their patients to this book' Michael Baum, MD, Professor Emeritus of Surgery and visiting professor of Medical Humanities, University College London 'A thorough, careful and unbiased assessment . . . This extremely valuable message deserves to be widely disseminated' Lord Turnberg, former President of the Royal College of Physicians A compelling defence of hormone replacement therapy, exposing the faulty science behind its fall from prominence and empowering readers to make informed decisions about their health. For years, hormone replacement therapy (HRT) was hailed as a miracle. Study after study showed that HRT, if initiated at the onset of menopause, could ease symptoms ranging from hot flushes to memory loss; reduce the risk of heart disease, Alzheimer's, osteoporosis, and some cancers; and even extend a woman's overall life expectancy. But when a large study by the Women's Health Initiative announced results showing an uptick in breast cancer among women taking HRT, the winds shifted abruptly, and HRT, officially deemed a carcinogen, was abandoned. Now, sixteen years after HRT was left for dead, Dr Bluming, a medical oncologist, and Dr Tavris, a social psychologist, track its strange history and present a compelling case for its resurrection. They investigate what led the public -- and much of the medical establishment -- to accept the Women's Health Initiative's often exaggerated claims, while also providing a fuller picture of the science that supports HRT. A sobering and revelatory read, Oestrogen Matters sets the record straight on this beneficial treatment and provides an empowering path to wellness for women everywhere.
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23.88 USD

Oestrogen Matters: Why Taking Hormones in Menopause Improves Women's Well-Being, Lengthens Their Lives-and Doesn't Raise the Risk of Breast Cancer

by Carol Tavris PhD, Avrum Bluming, MD
Paperback / softback
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Thyroid hormone plays an important role in development and functional maintenance in the central nervous system. Deficiency of thyroid hormone during fetal and early postnatal life induces abnormal development known as cretinism in humans. However, the molecular mechanism of thyroid hormone action has not yet been fully understood. Thyroid hormone ...
Thyroid Hormone Disruption and Neurodevelopment
Thyroid hormone plays an important role in development and functional maintenance in the central nervous system. Deficiency of thyroid hormone during fetal and early postnatal life induces abnormal development known as cretinism in humans. However, the molecular mechanism of thyroid hormone action has not yet been fully understood. Thyroid hormone action in the brain may be disrupted under various pathological conditions. In addition, environmental factors including endocrine-disrupting chemicals and bacterial endotoxins may disrupt thyroid hormone action in brain, causing abnormal brain development and functional disruption. This is a first book to comprehensively describe the effect of thyroid hormone disruption in the central nervous system. The first section deals with the disruption of thyroid hormone action at the molecular level. First the authors provide a summary of the possible molecular mechanisms of thyroid hormone action in the brain, then they discuss several factors that may disrupt thyroid hormone action. In the second section, animal models to study thyroid hormone action will be introduced. An interesting character of thyroid hormone deficiency is that, without thyroid hormone, the thyroid hormone receptor may act as a repressor of gene expression, causing more severe consequence than those of thyroid hormone receptor knockout animals. Thus, several different kind of animal models may be used to clarify the role of thyroid hormone and its receptor in the brain. In the third section, human studies on thyroid disease and neurodevelopment will be introduced. Although endemic cretinism induced by iodine deficiency and sporadic cretinism by various thyroid mutation are well known, the pathophysiological mechanisms that create each abnormal phenotype are not fully understood.
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209.990000 USD

Thyroid Hormone Disruption and Neurodevelopment

Paperback / softback
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How hormonal signals in one small structure of the brain-the hypothalamus-govern our physiology and behavior. As human beings, we prefer to think of ourselves as reasonable. But how much of what we do is really governed by reason? In this book, Gareth Leng considers the extent to which one small ...
The Heart of the Brain: The Hypothalamus and Its Hormones
How hormonal signals in one small structure of the brain-the hypothalamus-govern our physiology and behavior. As human beings, we prefer to think of ourselves as reasonable. But how much of what we do is really governed by reason? In this book, Gareth Leng considers the extent to which one small structure of the neuroendocrine brain-the hypothalamus-influences what we do, how we love, and who we are. The hypothalamus contains a large variety of neurons. These communicate not only through neurotransmitters, but also through peptide signals that act as hormones within the brain. While neurotransmitter signals tend to be ephemeral and confined by anatomical connectivity, the hormone signals that hypothalamic neurons generate are potent, wide-reaching, and long-lasting. Leng explores the evolutionary origins of these remarkable neurons, and where the receptors for their hormone signals are found in the brain. By asking how the hypothalamic neurons and their receptors are regulated, he explores how the hypothalamus links our passions with our reason. The Heart of the Brain shows in an accessible way how this very small structure is very much at the heart of what makes us human.
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36.750000 USD

The Heart of the Brain: The Hypothalamus and Its Hormones

by Gareth Leng
Hardback
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This practical book describes only neurometabolic hereditary diseases which have a specific treatment and encourages the general neurologist to think of the most common neurometabolic hereditary diseases, which he might have seen and never considered in the differential diagnosis. Information regarding how to deal with diseases with special therapy is ...
Neurometabolic Hereditary Diseases of Adults
This practical book describes only neurometabolic hereditary diseases which have a specific treatment and encourages the general neurologist to think of the most common neurometabolic hereditary diseases, which he might have seen and never considered in the differential diagnosis. Information regarding how to deal with diseases with special therapy is provided (i.e. enzymatic replacement therapy in Fabry disease and Pompe disease), as is information on diseases which are not easily recognized (i.e. Niemann-Pick disease type C), and diseases with clinical features mimicking other common neurodegenrative diseases (i.e. Wilson's disease). Neurometabolic Hereditary Diseases is written with a clinical focus for adult neurologists working in general hospitals.
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114.450000 USD

Neurometabolic Hereditary Diseases of Adults

Hardback
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In organizing the second edition of this renowned Handbook, Dr. Neoptolemos and his co-editors have produced and updated a revised edition to the distinguished Major Reference Work devoted to pancreatic cancer. Like its preceding edition, the second edition continues to have a widespread appeal among clinicians, pathologists and basic scientists, ...
Pancreatic Cancer
In organizing the second edition of this renowned Handbook, Dr. Neoptolemos and his co-editors have produced and updated a revised edition to the distinguished Major Reference Work devoted to pancreatic cancer. Like its preceding edition, the second edition continues to have a widespread appeal among clinicians, pathologists and basic scientists, who are now struggling to understand this complex and rapidly expanding field. Because of the recent and vast growth in both the clinical and scientific research being done in pancreatic cancer, (there is currently an unprecedented investment by academia and industry in this field), each research's knowledge of other specialty areas outside his or her own is often quite limited. The aim of the new edition is to place the tangible advances, including new developments in surgical approaches with regards to resection techniques, the state of laparoscopic approaches, the growing impact of surgical approaches in the management of recurrent pancreatic cancer, controversies in the management of IMPN as the precursor lesion for PDAC and others - readily at hand. The second edition focuses on advances that will not become dated, and the editors have chosen authors, who are the very best in each area.
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892.490000 USD

Pancreatic Cancer

Hardback
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Oxford Desk Reference: Endocrinology provides easy access to evidence-based materials for quick consultation but also provides an in-depth expert reference for clinical practice. It covers the process of diagnosis, investigation, and management, as well as information for patients. Internationally-renowned experts have brought together evidence, guidelines and their clinical expertise to ...
Oxford Desk Reference: Endocrinology
Oxford Desk Reference: Endocrinology provides easy access to evidence-based materials for quick consultation but also provides an in-depth expert reference for clinical practice. It covers the process of diagnosis, investigation, and management, as well as information for patients. Internationally-renowned experts have brought together evidence, guidelines and their clinical expertise to put trustworthy support at your fingertips. The vast spectrum of endocrine disorders are clearly laid out in self-contained topics for easy reference. Chapters build bridges between pathogenesis, clinical presentation, differential diagnosis and investigation to aid understanding. Careful consideration is given to establishing a diagnosis including the recognition, investigation and management of the rarer diagnoses. The practical treatment of everyday endocrine disorders and the management of life-long conditions are outlined in clear protocols. Chapters are organised by endocrine glands, disorders and syndromes and there are sections on the involvement of hormones in other specialities including endocrine oncology. The continuity from childhood to adolescent and adult endocrinology as well as the needs of older patients is explored in specific sections. Dedicated chapters cover the important roles endocrine specialist nurses play in patient management, and dietetic advice. The editors have included a wealth of practical resources including: DT A speedy reference section, which provides summaries and quick direction DT A patient advice and reference section, which supports face-to-face discussion with patients DT A medicolegal chapter, which outlines risk and DVLA regulations Oxford Desk Reference: Endocrinology is the ideal companion for consultants, registrars associate specialists and clinical assistants as well as those from other disciplines who share endocrine clinics including endocrine surgeons, oncologists, gynaecologists and paediatricians.
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94.500000 USD

Oxford Desk Reference: Endocrinology

Hardback
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Bringing together the latest knowledge on the growth and development of children and the most important abnormalities of puberty, this comprehensive text presents the current views on the pathogenesis, diagnostic possibilities and therapeutic options of the main deviations from the normal course of puberty (e.g., precocious and delayed puberty). The ...
Puberty: Physiology and Abnormalities
Bringing together the latest knowledge on the growth and development of children and the most important abnormalities of puberty, this comprehensive text presents the current views on the pathogenesis, diagnostic possibilities and therapeutic options of the main deviations from the normal course of puberty (e.g., precocious and delayed puberty). The chain of physical and hormonal changes in the transitional years is carefully followed, including the regulation of the hypothalamic pulse generator as well as the timing of puberty. Further topics include growth disturbances, adolescent varicocele, adolescent gynecomastia, polycystic ovary syndrome, pubertal acne, and the psychosocial development of adolescents with pubertal abnormalities. Written and edited by internationally noted experts, Puberty will be an excellent resource for pediatricians, endocrinologists, gynecologists, andrologists, urologists, family practitioners, child psychologists and public health specialists - all those who will be challenged in their everyday practice with the problems of puberty.
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146.990000 USD

Puberty: Physiology and Abnormalities

Paperback / softback
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This book indicates the technique and fine points of the mini- and one-anastomosis gastric bypass, and looks at the means of revising other operations related to it. The chapters discuss postoperative complications, treatment and requirements, postoperative diet and medications, the remarkable effects on the co-morbidities of morbid obesity, and the ...
Essentials of Mini - One Anastomosis Gastric Bypass
This book indicates the technique and fine points of the mini- and one-anastomosis gastric bypass, and looks at the means of revising other operations related to it. The chapters discuss postoperative complications, treatment and requirements, postoperative diet and medications, the remarkable effects on the co-morbidities of morbid obesity, and the durability of the weight loss, as well as the improvement in the quality of life. Essentials of Mini - One Anastomosis Gastric Bypass aims to help surgeons manage the difficulties encountered within this procedure and to help create improved practice.
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156.450000 USD

Essentials of Mini - One Anastomosis Gastric Bypass

Hardback
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Leading researchers are specially invited to provide a complete understanding of the key topics in these archetypal multidisciplinary fields. In a form immediately useful to scientists, this periodical aims to filter, highlight and review the latest developments in these rapidly advancing fields.
Reviews of Physiology, Biochemistry and Pharmacology Vol. 170
Leading researchers are specially invited to provide a complete understanding of the key topics in these archetypal multidisciplinary fields. In a form immediately useful to scientists, this periodical aims to filter, highlight and review the latest developments in these rapidly advancing fields.
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178.490000 USD

Reviews of Physiology, Biochemistry and Pharmacology Vol. 170

Paperback / softback
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This book reviews the growing literature that is consistent with the hypothesis that hormones can regulate auditory physiology and perception across a broad range of animal taxa, including humans. Understanding how hormones modulate auditory function has far reaching implications for advancing our knowledge in the basic biomedical sciences and in ...
Hearing and Hormones
This book reviews the growing literature that is consistent with the hypothesis that hormones can regulate auditory physiology and perception across a broad range of animal taxa, including humans. Understanding how hormones modulate auditory function has far reaching implications for advancing our knowledge in the basic biomedical sciences and in understanding the evolution of acoustic communication systems. A fundamental goal of neuroscience is to understand how hormones modulate neural circuits and behavior. For example, steroids such as estrogens and androgens are well-known regulators of vocal motor behaviors used during social acoustic communication. Recent studies have shown that these same hormones can also greatly influence the reception of social acoustic signals, leading to the more efficient exchange of acoustic information.
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178.490000 USD

Hearing and Hormones

Paperback / softback
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Removing the shroud of complexity that had engulfed the field of menopause research and management for more than a decade, this unique, case-based resource discusses a range of topics relevant to the reproductive health of the aging female. The opening section includes chapters covering the symptomatology, epidemiology and impact of ...
Essentials of Menopause Management: A Case-Based Approach
Removing the shroud of complexity that had engulfed the field of menopause research and management for more than a decade, this unique, case-based resource discusses a range of topics relevant to the reproductive health of the aging female. The opening section includes chapters covering the symptomatology, epidemiology and impact of the menopausal burden, and reviews in depth the most current evidence on the efficacy, risks and benefits of pharmacological and alternative therapies. Utilizing vibrant case material, the second section details common symptoms of menopause and an individualized approach to management, such as sleep loss, skeletal fragility, sexual dysfunction, hirsutism and alopecia, primary ovarian insufficiency and failure, and vasomotor symptoms. Chapters reviewing therapeutic options and considerations tailored to gynecologic and breast cancer patients and survivors comprise the third and final section. Developed as a multidisciplinary collaboration and addressing the needs of practicing reproductive medicine clinicians and researchers providing care to an aging female population, Essentials of Menopause Management provides clear, up-to-date information and recommendations on the range of current treatment strategies for menopause and its symptoms.
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157.490000 USD

Essentials of Menopause Management: A Case-Based Approach

Paperback / softback
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This book focuses on the use of various molecules with antioxidant properties in the treatment of major male genital tract disorders, especially male infertility, erectile dysfunction, and accessory gland infection. The coverage also includes discussion of pathophysiology, the molecular basis of male infertility, and the rationale for use of antioxidants, ...
Antioxidants in Andrology
This book focuses on the use of various molecules with antioxidant properties in the treatment of major male genital tract disorders, especially male infertility, erectile dysfunction, and accessory gland infection. The coverage also includes discussion of pathophysiology, the molecular basis of male infertility, and the rationale for use of antioxidants, with particular attention to coenzyme Q10 and carnitine. Oxidative stress occurs when the production of reactive oxygen species, including free radicals, exceeds the body's natural antioxidant defences, leading to cellular damage. Oxidative stress is present in about half of all infertile men, and reactive oxygen species can produce infertility both by damaging the sperm membrane, with consequences for sperm motility, and by altering the sperm DNA. There is consequently a clear rationale for the use of antioxidant treatments within andrology, and various in vitro and in vivo studies have indicated that many antioxidants indeed have beneficial impacts. In providing a detailed and up-to-date overview of the subject, this book will be of interest to both practitioners and researchers in andrology, endocrinology, and urology.
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104.990000 USD

Antioxidants in Andrology

Paperback / softback
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A cutting-edge yet practical guide for newly-diagnosed and established type 2 diabetes patients and their families, providing an understanding of what really causes the condition and therefore how to manage it effectively, by one of the UK's leading diabetes physicians. The book includes much that will be unfamiliar to non-specialist ...
Get Tough With Type 2: Master your diabetes
A cutting-edge yet practical guide for newly-diagnosed and established type 2 diabetes patients and their families, providing an understanding of what really causes the condition and therefore how to manage it effectively, by one of the UK's leading diabetes physicians. The book includes much that will be unfamiliar to non-specialist doctors, helping sufferers to manage their own condition better and work optimally with healthcare professionals: The primary problem is not blood glucose but fat in the wrong organs (liver and pancreas); Type 1 diabetes can masquerade as type 2 - the warning signs; Putting the Newcastle-type ultra-low-calorie diet into real life use; Managing cholesterol and blood pressure problems; Reasonable blood sugar levels and minimising medication; Overcoming complications; Questions patients should be asking
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25.58 USD

Get Tough With Type 2: Master your diabetes

by David Levy
Paperback / softback
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Recent years have seen spectacular advances in the field of circadian biology. These have attracted the interest of researchers in many fields, including endocrinology, neurosciences, cancer, and behavior. By integrating a circadian view within the fields of endocrinology and metabolism, researchers will be able to reveal many, yet-unsuspected aspects of ...
A Time for Metabolism and Hormones
Recent years have seen spectacular advances in the field of circadian biology. These have attracted the interest of researchers in many fields, including endocrinology, neurosciences, cancer, and behavior. By integrating a circadian view within the fields of endocrinology and metabolism, researchers will be able to reveal many, yet-unsuspected aspects of how organisms cope with changes in the environment and subsequent control of homeostasis. This field is opening new avenues in our understanding of metabolism and endocrinology. A panel of the most distinguished investigators in the field gathered together to discuss the present state and the future of the field. The editors trust that this volume will be of use to those colleagues who will be picking up the challenge to unravel how the circadian clock can be targeted for the future development of specific pharmacological strategies toward a number of pathologies.
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62.990000 USD

A Time for Metabolism and Hormones

Paperback / softback
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This volume starts with an elementary introduction covering stem cell methodologies used to produce specific types of neurons, possibilities for their therapeutic use, and warnings of technical problems. In addition the authors report successes in achieving the derivation of a specific type of neuron. The dopamine neuron offers an important ...
Stem Cells in Neuroendocrinology
This volume starts with an elementary introduction covering stem cell methodologies used to produce specific types of neurons, possibilities for their therapeutic use, and warnings of technical problems. In addition the authors report successes in achieving the derivation of a specific type of neuron. The dopamine neuron offers an important example and is discussed in more detail. Additional chapters cover problems obviously approachable with cells derived from stem cells, including their need in surgeries for pituitary cancers. The last chapter provides an overview of this particular field of research and presents a vision for its future directions.
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62.990000 USD

Stem Cells in Neuroendocrinology

Paperback / softback
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This book presents the state of the art in the pathophysiology, diagnosis, and therapy of hypothalamic and pituitary disorders. After an introduction devoted to the physiology of the neuroendocrine control of the hypothalamic-pituitary unit, the diverse disorders involving hormonal excess or deficiency are systematically addressed axis by axis. For each ...
Hypothalamic-Pituitary Diseases
This book presents the state of the art in the pathophysiology, diagnosis, and therapy of hypothalamic and pituitary disorders. After an introduction devoted to the physiology of the neuroendocrine control of the hypothalamic-pituitary unit, the diverse disorders involving hormonal excess or deficiency are systematically addressed axis by axis. For each disorder, pathophysiology, clinical presentation, and management are discussed in detail. In addition, individual chapters focus on the neuroendocrinology of energy homeostasis and of bone metabolism, metabolic derangement secondary to pituitary dysfunction, and pituitary control of the endocrine pancreas. While the focus of the book is predominantly on pathophysiological and clinical aspects, due attention is also devoted to potential diagnostic and therapeutic innovations. The book is intended as a major reference for endocrinologists and basic and clinical scientists.
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313.950000 USD

Hypothalamic-Pituitary Diseases

Hardback
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Estrogen Matters: Why Taking Hormones in Menopause Can Improve Women's Well-Being and Lengthen Their Lives -- Without Raising the Risk of Breast Cancer
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36.750000 USD

Estrogen Matters: Why Taking Hormones in Menopause Can Improve Women's Well-Being and Lengthen Their Lives -- Without Raising the Risk of Breast Cancer

by Carol Tavris, Avrum Bluming
CD-Audio
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The Healing Self Food Journal and Activity Tracker: 90days Discover the Secret to Permanent Weight Loss to the Body You Want
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9.120000 USD

The Healing Self Food Journal and Activity Tracker: 90days Discover the Secret to Permanent Weight Loss to the Body You Want

by Jean Staley
Paperback / softback
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Estrogen Matters
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28.350000 USD

Estrogen Matters

by Carol Tavris, Avrum Bluming
Hardback
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This book presents the state of the art of type 2 diabetes genetics, from the process of genetic discovery to its interpretation and clinical application, and illustrates a model for other complex human phenotypes.The first section explores genome-wide association studies, the extension of this method to less accessible phenotypes and ...
The Genetics of Type 2 Diabetes and Related Traits: Biology, Physiology and Translation
This book presents the state of the art of type 2 diabetes genetics, from the process of genetic discovery to its interpretation and clinical application, and illustrates a model for other complex human phenotypes.The first section explores genome-wide association studies, the extension of this method to less accessible phenotypes and the arrival of next-generation sequencing. A further section goes beyond genetics to illustrate how other data sources can help interpret genetic data, such as leveraging population diversity, the correlation of genetic associations with physiological measurements, gene expression modulation, environmental factors and our microbial commensals. The third section describes advances in elucidating the complex path from association to function using in-depth sequencing and functional studies of the cellular and molecular effects of genes in the loci identified by genetics. The final section links our current understanding with clinically relevant questions, such as prediction, interactions with drugs or nutrients, and disease prevention, and paints a realistic but hopeful vision of the future.
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230.990000 USD

The Genetics of Type 2 Diabetes and Related Traits: Biology, Physiology and Translation

Paperback
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Thyroid Support Supplement: Master Guide: Boost Your Energy, Libido, Retentive Memory Capacity, Mental Clarity, Focus, Cognition, Sharpen Mind, Enrich Mood, Enhance Metabolism & Be Free from Depression, Stress & Anxiety with Thyroid Support Supplement. Wh
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12.590000 USD

Thyroid Support Supplement: Master Guide: Boost Your Energy, Libido, Retentive Memory Capacity, Mental Clarity, Focus, Cognition, Sharpen Mind, Enrich Mood, Enhance Metabolism & Be Free from Depression, Stress & Anxiety with Thyroid Support Supplement. Wh

by Dr Ashley Diamond
Paperback
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This book aims to present a comprehensive classification of hypertensive phenotypes based on underlying target organ involvement. Particular emphasis is placed on review and assessment of clinical presentation, pathophysiologic mechanisms, and possible specific therapeutic options for each hypertension phenotype. Several of these phenotypes are well known and well described in ...
Disorders of Blood Pressure Regulation: Phenotypes, Mechanisms, Therapeutic Options
This book aims to present a comprehensive classification of hypertensive phenotypes based on underlying target organ involvement. Particular emphasis is placed on review and assessment of clinical presentation, pathophysiologic mechanisms, and possible specific therapeutic options for each hypertension phenotype. Several of these phenotypes are well known and well described in the literature, such as prehypertension, white coat and masked hypertension, isolated systolic hypertension, renovascular hypertension, endocrine hypertension, pediatric hypertension, and gestational hypertension. Other hypertension phenotypes, however, are not widely recognized, being reported only in special reviews; examples include hypertension associated with renal calculus disease and other rarer causes such as Turner syndrome, herbal and medicinal compounds, and pharmacologic agents. A detailed account of the various causes of monogenic hypertension is also included. Finally, a section is devoted to general aspects of hypertension, including the significance of blood pressure indices, the natural course of untreated and treated hypertension, hypertension mechanisms, genetics, and guidelines for blood pressure control.
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334.950000 USD

Disorders of Blood Pressure Regulation: Phenotypes, Mechanisms, Therapeutic Options

Hardback
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This handbook compiles comprehensive reference information on sweeteners for academic researchers and professionals. It discusses both natural as well as synthetic products, considering health-related and economical aspects. Renowned authors mostly from academia, but also from the industry, summarize information about the chemistry, biological and pharmacological aspects, as well as bioavailability ...
Sweeteners: Pharmacology, Biotechnology, and Applications
This handbook compiles comprehensive reference information on sweeteners for academic researchers and professionals. It discusses both natural as well as synthetic products, considering health-related and economical aspects. Renowned authors mostly from academia, but also from the industry, summarize information about the chemistry, biological and pharmacological aspects, as well as bioavailability and applications of sweeteners. The book introduces various substance classes of sweeteners, which are mainly plant-derived, including glycosidic and terpenoid sweeteners, peptidic sweeteners, sweet-tasting proteins and protein-derived sweeteners (e.g. stevioside, sucralose, aspartame, thaumatin, brazzein and many more). Chapters address topics such as the isolation and purification of the compounds, their physical, chemical and biological properties, pharmacological activities, and also critically discuss their applications in view of health and ecotoxicological aspects. A special emphasis is on low or no-calorie sweeteners, for which there is an increasing demand and intensified research activities currently. This reference work hence provides the readers with key information and will serve the needs of graduate students and scholars, researchers and professionals working in the fields of chemistry, botany, biotechnology, or pharmacological or agricultural research, as well as in the food industry or the marketing of sweeteners.
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313.950000 USD

Sweeteners: Pharmacology, Biotechnology, and Applications

Hardback
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This volume represents an up-to-date overview on pre-Menopause and Menopause, with their respective clinical implications and therapies. The aim is to clarify possible doubts and clinical approaches to this particular period in a woman's life and how to face it, both offering solutions to actual problems and focusing on the ...
Pre-Menopause, Menopause and Beyond: Volume 5 Frontiers in Gynecological Endocrinology
This volume represents an up-to-date overview on pre-Menopause and Menopause, with their respective clinical implications and therapies. The aim is to clarify possible doubts and clinical approaches to this particular period in a woman's life and how to face it, both offering solutions to actual problems and focusing on the potential impact of preventive medicine in improving women's health and quality of life. The volume is published within the International Society of Gynecological Endocrinology (ISGE) Series, and is based on the 2017 International School of Gynecological and Reproductive Endocrinology Winter Course. This book, covering a very wide range of topics with particular focus on fertility in pre- and peri-menopausal women, climacteric and menopausal symptoms, impact of PCOS on post-menopausal health, breast disease, surgical treatments and therapies, will be an invaluable tool for gynecologists, endocrinologists, and experts in women's health.
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94.490000 USD

Pre-Menopause, Menopause and Beyond: Volume 5 Frontiers in Gynecological Endocrinology

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The revised and updated second edition of a multidisciplinary, evidence-based clinical guide for the care of pregnant women with diabetes The second edition of A Practical Manual of Diabetes in Pregnancy offers a wealth of new evidence, new material, new technologies, and the most current approaches to care. With contributions ...
A Practical Manual of Diabetes in Pregnancy
The revised and updated second edition of a multidisciplinary, evidence-based clinical guide for the care of pregnant women with diabetes The second edition of A Practical Manual of Diabetes in Pregnancy offers a wealth of new evidence, new material, new technologies, and the most current approaches to care. With contributions from a team of international experts, the manual is highly accessible and comprehensive in scope. It covers topics ranging from preconception to postnatal care, details the risks associated with diabetic pregnancy, and the long-term implications for the mother and baby. The text also explores recent controversies and examines thorny political pressures. The manual s treatment recommendations are based on the latest research to ensure pregnant women with diabetes receive the best possible care. The text takes a multi-disciplinary approach that reflects best practice in the treatment of diabetes in pregnancy. The revised second edition includes: New chapters on the very latest topics of interest Contributions from an international team of noted experts Practical, state-of-the-art text that has been fully revised with the latest in clinical guidance Easy-to-read, accessible format in two-color text design Illustrative case histories, practice points, and summary boxes, future directions, as well as pitfalls and what to avoid boxes Multiple choice questions with answers in each chapter Comprehensive and practical, the text is ideal for use in clinical settings for reference by all members of the multi-disciplinary team who care for pregnant women with diabetes. The manual is also designed for learning and review purposes by trainees in endocrinology, diabetes, and obstetrics.
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152.250000 USD

A Practical Manual of Diabetes in Pregnancy

Hardback
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