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This is the second edition of a well-received book in the series Drug Discovery and Evaluation The completely revised new edition of the volume reflects the current state of the art in Clinical Pharmacology. Drug Discovery and Evaluation has become a more and more difficult, expensive and time-consuming process. The ...
Drug Discovery and Evaluation: Methods in Clinical Pharmacology
This is the second edition of a well-received book in the series Drug Discovery and Evaluation The completely revised new edition of the volume reflects the current state of the art in Clinical Pharmacology. Drug Discovery and Evaluation has become a more and more difficult, expensive and time-consuming process. The effect of a new compound has to be detected by in vitro and in vivo methods of pharmacology. The activity spectrum and the potency compared to existing drugs have to be determined. As these processes can be divided up stepwise we have designed a book series Drug Discovery and Evaluation in the form of a recommendation document. Clinical pharmacokinetics are performed in parallel with human studies on tolerability and therapeutic effects. Special studies according to various populations and different therapeutic indications are necessary. These items are covered in the third volume: Methods in Clinical Pharmacology . For the 2nd edition of this volume, the chapters have been revised and completely updated. A large number of assays were added. New chapters were included, such as pain, addiction, gene therapy, orphan diseases.
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839.990000 USD

Drug Discovery and Evaluation: Methods in Clinical Pharmacology

Hardback
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Naturally Occurring Chemicals Against Alzheimer's Disease offers a detailed discussion on the roles, molecular mechanisms, structural activity relationships, toxicology and clinical data on phytochemicals in relation to Alzheimer's disease. The book examines the available phytochemicals and plants that are potentially effective, also determining the role and molecular targets of these ...
Naturally Occurring Chemicals Against Alzheimer's Disease
Naturally Occurring Chemicals Against Alzheimer's Disease offers a detailed discussion on the roles, molecular mechanisms, structural activity relationships, toxicology and clinical data on phytochemicals in relation to Alzheimer's disease. The book examines the available phytochemicals and plants that are potentially effective, also determining the role and molecular targets of these phytochemicals in combating AD. This comprehensive resource will be helpful to researchers who are working on herbal drugs on AD, phytochemistry, pharmacology, toxicology, clinical trials, neuroscience and advancement in formulations.
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236.250000 USD

Naturally Occurring Chemicals Against Alzheimer's Disease

Paperback / softback
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Our genome is the blueprint to our existence: it encodes all the information we need to develop from a single cell into a hugely complicated functional organism. But it is more than a static information store: our genome is a dynamic, tightly-regulated collection of genes, which switch on and off ...
Introduction to Genomics
Our genome is the blueprint to our existence: it encodes all the information we need to develop from a single cell into a hugely complicated functional organism. But it is more than a static information store: our genome is a dynamic, tightly-regulated collection of genes, which switch on and off in many combinations to give the variety of cells from which our bodies are formed. But how do we identify the genes that make up our genome? How do we determine their function? And how do different genes form the regulatory networks that direct the processes of life? Introduction to Genomics is a fascinating insight into what can be revealed from the study of genomes: how organisms differ or match; how different organisms evolved; how the genome is constructed and how it operates; and what our understanding of genomics means in terms of our future health and wellbeing. Covering the latest techniques that enable us to study the genome in ever-increasing detail, the book explores what the genome tells us about life at the level of the molecule, the cell, and the organism. Learning features throughout make this book the ideal teaching and learning tool: extensive end of chapter exercises and problems help the student to fully grasp the concepts being presented, while end of chapter weblems (web-based problems) and lab assignments give the student the opportunity to engage with the subject in a hands-on manner. The field of genomics is enabling us to analyze life in more detail than ever before; Introduction to Genomics is the perfect guide to this enthralling subject. Online Resource Centre The Online Resource Centre to accompany Introduction to Genomics features For lecturers: Figures from the book in electronic format For students: Answers to end-of-chapter exercises Guided tour of web sites in genomics Hints to end-of-chapter problems Rotating figures
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78.09 USD

Introduction to Genomics

by Arthur M. Lesk
Paperback
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Magnetic resonance imaging (MRI) has become the leading cross-sectional imaging method in clinical practice. Continuous technical improvements have significantly broadened the scope of applications. At present, MR imaging is not only the most important diagnostic technique in neuroradiology and musculoskeletal radiology, but has also become an invaluable diagnostic tool for ...
Clinical MR Imaging: A Practical Approach
Magnetic resonance imaging (MRI) has become the leading cross-sectional imaging method in clinical practice. Continuous technical improvements have significantly broadened the scope of applications. At present, MR imaging is not only the most important diagnostic technique in neuroradiology and musculoskeletal radiology, but has also become an invaluable diagnostic tool for abdominal, pelvic, cardiac, breast and vascular imaging. This book offers practical guidelines for performing efficient and cost-effective MRI examinations in daily practice. The underlying idea is that, by adopting a practical protocol-based approach, the work-flow in a MRI unit can be streamlined and optimized.
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293.990000 USD

Clinical MR Imaging: A Practical Approach

Hardback
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Metabolism at a Glance is a complete review course of metabolism in health and disease and offers a unique approach to the study of this difficult discipline. Metabolism is a complicated subject involving complex molecules and interrelated pathways. These metabolic pathways are usually taught separately with the result that the ...
Metabolism at a Glance
Metabolism at a Glance is a complete review course of metabolism in health and disease and offers a unique approach to the study of this difficult discipline. Metabolism is a complicated subject involving complex molecules and interrelated pathways. These metabolic pathways are usually taught separately with the result that the student develops a detailed but compartmentalised approach to metabolism and frequently fails to see the overall picture and its physiological significance. Using the at a Glance format, the book takes the student through a complete course in intermediary metabolism in an integrated manner. The same chart is repeated throughout the book with the individual pathway under study highlighted. The book is an ideal text for introductory biochemistry courses and has established itself as an enormously popular book amongst lecturers and students alike. This third edition is fully updated and includes five new chapters to mirror those topics currently taught at undergraduate level: 1. Metabolic Channelling 2. Glucose homeostasis and Reye's Disease 3. Pentose phosphate pathway and the prodcution of NADPH 4. Tryptophan metabolism in health and disease 5. Tyrosine metabolism in health and disease
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53.92 USD

Metabolism at a Glance

by J. G. Salway
Paperback
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This book is an accessible resource offering practical information not found in more database-oriented resources. The first chapter lists acronyms with definitions, and a glossary of terms and subjects used in biochemistry, molecular biology, biotechnology, proteomics, genomics, and systems biology. There follows chapters on chemicals employed in biochemistry and molecular ...
Biochemistry and Molecular Biology Compendium
This book is an accessible resource offering practical information not found in more database-oriented resources. The first chapter lists acronyms with definitions, and a glossary of terms and subjects used in biochemistry, molecular biology, biotechnology, proteomics, genomics, and systems biology. There follows chapters on chemicals employed in biochemistry and molecular biology, complete with properties and structure drawings. Researchers will find this book to be a valuable tool that will save them time, as well as provide essential links to the roots of their science. Key selling features: Contains an extensive list of commonly used acronyms with definitions Offers a highly readable glossary for systems and techniques Provides comprehensive information for the validation of biotechnology assays and manufacturing processes Includes a list of Log P values, water solubility, and molecular weight for selected chemicals Gives a detailed listing of protease inhibitors and cocktails, as well as a list of buffers
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288.25 USD

Biochemistry and Molecular Biology Compendium

by Roger L. Lundblad
Hardback
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Artificial organs may be considered as small-scale process plants, in which heat, mass and momentum transfer operations and, possibly, chemical transformations are carried out. This book proposes a novel analysis of artificial organs based on the typical bottom-up approach used in process engineering. Starting from a description of the fundamental ...
Artificial Organ Engineering
Artificial organs may be considered as small-scale process plants, in which heat, mass and momentum transfer operations and, possibly, chemical transformations are carried out. This book proposes a novel analysis of artificial organs based on the typical bottom-up approach used in process engineering. Starting from a description of the fundamental physico-chemical phenomena involved in the process, the whole system is rebuilt as an interconnected ensemble of elemental unit operations. Each artificial organ is presented with a short introduction provided by expert clinicians. Devices commonly used in clinical practice are reviewed and their performance is assessed and compared by using a mathematical model based approach. Whilst mathematical modelling is a fundamental tool for quantitative descriptions of clinical devices, models are kept simple to remain focused on the essential features of each process. Postgraduate students and researchers in the field of chemical and biomedical engineering will find that this book provides a novel and useful tool for the analysis of existing devices and, possibly, the design of new ones. This approach will also be useful for medical researchers who want to get a deeper insight into the basic working principles of artificial organs.
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178.490000 USD

Artificial Organ Engineering

by Luca Turchetti, Vincenzo Piemonte, Luigi Marrelli, Maria Cristina Annesini
Hardback
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This book presents cutting-edge research and applications of deep learning in a broad range of medical imaging scenarios, such as computer-aided diagnosis, image segmentation, tissue recognition and classification, and other areas of medical and healthcare problems. Each of its chapters covers a topic in depth, ranging from medical image synthesis ...
Deep Learning in Medical Image Analysis: Challenges and Applications
This book presents cutting-edge research and applications of deep learning in a broad range of medical imaging scenarios, such as computer-aided diagnosis, image segmentation, tissue recognition and classification, and other areas of medical and healthcare problems. Each of its chapters covers a topic in depth, ranging from medical image synthesis and techniques for muskuloskeletal analysis to diagnostic tools for breast lesions on digital mammograms and glaucoma on retinal fundus images. It also provides an overview of deep learning in medical image analysis and highlights issues and challenges encountered by researchers and clinicians, surveying and discussing practical approaches in general and in the context of specific problems. Academics, clinical and industry researchers, as well as young researchers and graduate students in medical imaging, computer-aided-diagnosis, biomedical engineering and computer vision will find this book a great reference and very useful learning resource.
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230.990000 USD

Deep Learning in Medical Image Analysis: Challenges and Applications

Hardback
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This book, now in an extensively revised second edition, describes the crucial role of zinc signaling in biological processes on a molecular and physiological basis. Global leaders in the field review the latest knowledge, including the very significant advances in understanding that have been achieved since publication of the first ...
Zinc Signaling
This book, now in an extensively revised second edition, describes the crucial role of zinc signaling in biological processes on a molecular and physiological basis. Global leaders in the field review the latest knowledge, including the very significant advances in understanding that have been achieved since publication of the first edition. Detailed information is provided on all the essentials of zinc signaling, covering molecular aspects and the roles of zinc transporters, the zinc sensing receptor, and metallothioneins. Detection techniques for zinc signals, involving genetically encoded and chemical probes, are also described. The critical contributions of the zinc signal in maintaining health and the adverse consequences of any imbalance in the signal are then thoroughly addressed. Here, readers will find up-to-date information on the significance of the zinc signal in a wide range of conditions, including cardiovascular disorders, neurodegenerative diseases, diabetes, autoimmune diseases, inflammatory conditions, skin disease, osteoarthritis, and cancer. The book will be of value for researchers, clinicians, and advanced students.
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262.490000 USD
Hardback
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This book focuses on thoracic ultrasound, a versatile, diagnostically accurate, low-cost, noninvasive and non-ionizing imaging technique. Thanks to portable devices, the method can be used to provide quick and accurate diagnoses in emergency settings, during transport, or at the patient's bedside in intensive care units. In addition, as a dynamic ...
Thoracic Ultrasound and Integrated Imaging
This book focuses on thoracic ultrasound, a versatile, diagnostically accurate, low-cost, noninvasive and non-ionizing imaging technique. Thanks to portable devices, the method can be used to provide quick and accurate diagnoses in emergency settings, during transport, or at the patient's bedside in intensive care units. In addition, as a dynamic examination that allows real-time assessment, it can be used to optimize diagnoses, the use of respiratory support equipment, surgical interventions and physiopathological assessments, both in critical patients and those with chronic conditions. Lastly, since it avoids ionizing radiation, thoracic ultrasound offers a first-line diagnostic tool for thoracic disease assessment in connection with pregnancy, neonatology and pediatrics. Pursuing a practical approach, this book also addresses the technological components that are needed in order to adequately set up the equipment. This integrated approach provides non-radiologists with essential know-how on using thoracic ultrasound as an extension of their physical examinations. Specific chapters are dedicated to thoracic ultrasound applications in neonatology, pediatrics and emergency medicine, as well as guided procedures and diaphragm function studies. Thoracic ultrasound has been a central element in the editors' clinical and experimental work for several years, and the book also includes contributions by prominent international experts on specific applications. Given its content and scope, the book will be of interest to all medical practitioners seeking a practical approach to thoracic ultrasound.
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146.990000 USD
Hardback
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Principles of Immunopharmacology provides a unique source of essential knowledge on the immune response, its diagnosis and its modification by drugs and chemicals. The 4th edition of this internationally recognized textbook has been revised to include recent developments, but continues the established format, dealing with four related fields in a ...
Nijkamp and Parnham's Principles of Immunopharmacology
Principles of Immunopharmacology provides a unique source of essential knowledge on the immune response, its diagnosis and its modification by drugs and chemicals. The 4th edition of this internationally recognized textbook has been revised to include recent developments, but continues the established format, dealing with four related fields in a single volume, thus obviating the need to refer to several different textbooks. The first section of the book, providing a basic introduction to immunology and its relevance for human disease, has been updated to accommodate new immunological concepts, particularly the role of epigenetics and the latest understanding of cancer immunology. The second section on immunodiagnostics offers a topical description of widely used molecular techniques and a new chapter on imaging techniques. This is followed by a systematic coverage of drugs affecting the immune system, including natural products. This third section contains 15 updated chapters, covering classical immunopharmacological topics such as anti-asthmatic, anti-rheumatic and immunosuppressive drugs, but also deals with antibiotics, plant-derived and dietary agents, with new chapters on monoclonal antibodies, immunotherapy in sepsis and infection, drugs for soft-tissue autoimmunity and cell therapy. The book concludes with a chapter on immunotoxicology and drug safety tests. Aids to the reader include a two-column format, glossaries of technical terms and appendix reference tables. The emphasis on illustrations is maintained from the first three editions. The book is a valuable single reference for undergraduate and graduate medical and biomedical students, postgraduate chemistry and pharmacy students, researchers in chemistry, biochemistry and the pharmaceutical industry and researchers lacking basic immunological knowledge, who want to understand the actions of drugs on the immune system.
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146.990000 USD
Paperback / softback
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This book is the outcome of a fruitful, long-standing cooperation between expert radiologists and clinicians, and explains the most relevant features and technical requirements that are needed to optimally conduct and assess MR examinations for temporomandibular joint (TMJ) pathologies. TMJ conditions are increasingly gaining attention, as the underlying diseases involved ...
MRI of the Temporomandibular Joint: Correlation Between Imaging and Pathology
This book is the outcome of a fruitful, long-standing cooperation between expert radiologists and clinicians, and explains the most relevant features and technical requirements that are needed to optimally conduct and assess MR examinations for temporomandibular joint (TMJ) pathologies. TMJ conditions are increasingly gaining attention, as the underlying diseases involved can vary considerably and be difficult to diagnose. Similarly, several imaging sub-specialties (e.g. dental radiology, neuroradiology, and musculoskeletal radiology) now find themselves dealing with the temporomandibular joints. The authors provide essential information on TMJ anatomy, dynamics, function and dysfunction. Correlations between clinical aspects and MRI findings are discussed and guidance for the correct interpretation of results is offered. Special findings that are helpful for differential diagnosis (arthritis, osteochondroma, synovial chondromatosis) are also examined. Given its extensive and varied coverage, the book offers a valuable asset for radiologists, dentists, gnathologists, maxillofacial surgeons, orthodontists and other professionals seeking a thorough overview of the subject
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157.490000 USD

MRI of the Temporomandibular Joint: Correlation Between Imaging and Pathology

Hardback
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The book is an on-the-spot reference for residents and medical students seeking diagnostic radiology fast facts. Its question-and-answer format makes it a perfect quick-reference for personal review and studying for board examinations and re-certification. Readers can read the text from cover to cover to gain a general foundation of knowledge ...
Essential Radiology Review: A Question and Answer Guide
The book is an on-the-spot reference for residents and medical students seeking diagnostic radiology fast facts. Its question-and-answer format makes it a perfect quick-reference for personal review and studying for board examinations and re-certification. Readers can read the text from cover to cover to gain a general foundation of knowledge that can be built upon through practice or can use choice chapters to review a specific subspecialty before starting a new rotation or joining a new service. With hundreds of high-yield questions and answer items, this resource addresses both general and subspecialty topics and provides accurate, on-the-spot answers. Sections are organized by subspecialty and body area, including chest, abdomen, and trauma, and chapters cover the anatomy, pathophysiology, differential diagnosis, hallmark signs, and image features of major diseases and conditions. Key example images and illustrations enhance the text throughout and provide an ideal, pocket-sized resource for residents and medical students.
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157.490000 USD

Essential Radiology Review: A Question and Answer Guide

Paperback / softback
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This publication is based on peer-reviewed manuscripts from the 2019 Conference on Drug Design & Discovery Technologies (CDDT) held at Ramaiah University of Applied Sciences, India. Providing a wide range of up to date topics on the latest advancements in drug design and discovery technologies, this book ensures the reader ...
Conference on Drug Design and Discovery Technologies
This publication is based on peer-reviewed manuscripts from the 2019 Conference on Drug Design & Discovery Technologies (CDDT) held at Ramaiah University of Applied Sciences, India. Providing a wide range of up to date topics on the latest advancements in drug design and discovery technologies, this book ensures the reader receives a good understanding of the scope of the field. Aimed at scientists, students, regulators, academics and consultants throughout the world, this book is an ideal resource for anyone interested in the state of the art in drug design and discovery.
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183.750000 USD

Conference on Drug Design and Discovery Technologies

Hardback
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Over the years, researchers have reported solubility data in the chemical, pharmaceutical, engineering, and environmental literature for several thousand organic compounds. Until the first publication of the Handbook of Aqueous Solubility Data, this information had been scattered throughout numerous sources. Now newly revised, the second edition of this landmark volume ...
Handbook of Aqueous Solubility Data
Over the years, researchers have reported solubility data in the chemical, pharmaceutical, engineering, and environmental literature for several thousand organic compounds. Until the first publication of the Handbook of Aqueous Solubility Data, this information had been scattered throughout numerous sources. Now newly revised, the second edition of this landmark volume continues the tradition of providing an extensive compilation of published aqueous solubility data for a wide variety of organic nonelectrolytes and unionized weak electrolytes. Adds data on 500 more organic compounds This latest edition adds 2000 new solubility values, bringing the total count to over 18,000 data points. Almost 500 organic compounds have been added, increasing the total number to 4661. This volume includes data for pharmaceuticals, pollutants, nutrients, herbicides, and pesticides as well as agricultural, industrial, and energy-related compounds. The same convenient format Each compound is identified by a sequential number along with molecular formula, compound name, synonyms, molecular weight, Chemical Abstracts Service Registry Number, melting point, and boiling point if available. Each entry has a five-point evaluation score for the quality of the reporting of the data, along with the full citation, and comments from the authors when necessary. The user-friendly format gives a clear depiction of each piece of solubility data with enough information to estimate its validity. The Handbook of Aqueous Solubility Data gives scientists in a broad range of fields a portable, accessible resource for solubility data of numerous compounds and a single system for the evaluation of the data supplied.
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102.27 USD

Handbook of Aqueous Solubility Data

by Parijat Jain, Yan He, Samuel H. Yalkowsky
Paperback / softback
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This introduction to medical imaging introduces all of the major medical imaging techniques in wide use in both medical practice and medical research, including Computed Tomography, Ultrasound, Positron Emission Tomography, Single Photon Emission Tomography and Magnetic Resonance Imaging. Principles of Medical Imaging for Engineers introduces fundamental concepts related to why ...
Principles of Medical Imaging for Engineers: From Signals to Images
This introduction to medical imaging introduces all of the major medical imaging techniques in wide use in both medical practice and medical research, including Computed Tomography, Ultrasound, Positron Emission Tomography, Single Photon Emission Tomography and Magnetic Resonance Imaging. Principles of Medical Imaging for Engineers introduces fundamental concepts related to why we image and what we are seeking to achieve to get good images, such as the meaning of 'contrast' in the context of medical imaging. This introductory text separates the principles by which 'signals' are generated and the subsequent 'reconstruction' processes, to help illustrate that these are separate concepts and also highlight areas in which apparently different medical imaging methods share common theoretical principles. Exercises are provided in every chapter, so the student reader can test their knowledge and check against worked solutions and examples. The text considers firstly the underlying physical principles by which information about tissues within the body can be extracted in the form of signals, considering the major principles used: transmission, reflection, emission and resonance. Then, it goes on to explain how these signals can be converted into images, i.e., full 3D volumes, where appropriate showing how common methods of 'reconstruction' are shared by some imaging methods despite relying on different physics to generate the 'signals'. Finally, it examines how medical imaging can be used to generate more than just pictures, but genuine quantitative measurements, and increasingly measurements of physiological processes, at every point within the 3D volume by methods such as the use of tracers and advanced dynamic acquisitions. Principles of Medical Imaging for Engineers will be of use to engineering and physical science students and graduate students with an interest in biomedical engineering, and to their lecturers.
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94.490000 USD

Principles of Medical Imaging for Engineers: From Signals to Images

by Michael Chappell
Hardback
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Hyperspectral Imaging, Volume 32, presents a comprehensive exploration of the different analytical methodologies applied on hyperspectral imaging and a state-of-the-art analysis of applications in different scientific and industrial areas. This book presents, for the first time, a comprehensive collection of the main multivariate algorithms used for hyperspectral image analysis in ...
Hyperspectral Imaging: Volume 32
Hyperspectral Imaging, Volume 32, presents a comprehensive exploration of the different analytical methodologies applied on hyperspectral imaging and a state-of-the-art analysis of applications in different scientific and industrial areas. This book presents, for the first time, a comprehensive collection of the main multivariate algorithms used for hyperspectral image analysis in different fields of application. The benefits, drawbacks and suitability of each are fully discussed, along with examples of their application. Users will find state-of-the art information on the machinery for hyperspectral image acquisition, along with a critical assessment of the usage of hyperspectral imaging in diverse scientific fields.
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236.250000 USD

Hyperspectral Imaging: Volume 32

Paperback / softback
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This book presents up-to-date information on clinical and research applications of imaging in peripheral arterial disease (PAD). It provides high-quality images useful not only in the diagnosis of PAD but also for use in clinical trials aimed at the development of novel therapies such as angiogenic agents and stem cells. ...
Imaging in Peripheral Arterial Disease: Clinical and Research Applications
This book presents up-to-date information on clinical and research applications of imaging in peripheral arterial disease (PAD). It provides high-quality images useful not only in the diagnosis of PAD but also for use in clinical trials aimed at the development of novel therapies such as angiogenic agents and stem cells. The book begins with coverage of the applications of the four major imaging modalities in a clinical setting: ultrasound, computed tomography angiography (CTA), magnetic resonance angiography (MRA), and digital subtraction angiography (DSA). It also discusses the ankle brachial index (ABI) as a screening technique to establish the presence of PAD. Subsequent chapters focus on the advantages and limitations of various research applications of imaging in PAD including contrast ultrasound for measuring perfusion; MRI for assessing perfusion, energetics, plaque volume, and characteristics; and radionuclide imaging for perfusion and inflammation. Imaging in Peripheral Arterial Disease: Clinical and Research Applications is an essential resource for physicians, researchers, residents, and fellows in cardiology, radiology, imaging, nuclear medicine, diagnostic radiology, and vascular surgery.
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146.990000 USD

Imaging in Peripheral Arterial Disease: Clinical and Research Applications

Hardback
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This book discusses the modeling and analysis of magnetic resonance imaging (MRI) data acquired from the human brain. The data processing pipelines described rely on R. The book is intended for readers from two communities: Statisticians who are interested in neuroimaging and looking for an introduction to the acquired data ...
Magnetic Resonance Brain Imaging: Modeling and Data Analysis Using R
This book discusses the modeling and analysis of magnetic resonance imaging (MRI) data acquired from the human brain. The data processing pipelines described rely on R. The book is intended for readers from two communities: Statisticians who are interested in neuroimaging and looking for an introduction to the acquired data and typical scientific problems in the field; and neuroimaging students wanting to learn about the statistical modeling and analysis of MRI data. Offering a practical introduction to the field, the book focuses on those problems in data analysis for which implementations within R are available. It also includes fully worked examples and as such serves as a tutorial on MRI analysis with R, from which the readers can derive their own data processing scripts. The book starts with a short introduction to MRI and then examines the process of reading and writing common neuroimaging data formats to and from the R session. The main chapters cover three common MR imaging modalities and their data modeling and analysis problems: functional MRI, diffusion MRI, and Multi-Parameter Mapping. The book concludes with extended appendices providing details of the non-parametric statistics used and the resources for R and MRI data.The book also addresses the issues of reproducibility and topics like data organization and description, as well as open data and open science. It relies solely on a dynamic report generation with knitr and uses neuroimaging data publicly available in data repositories. The PDF was created executing the R code in the chunks and then running LaTeX, which means that almost all figures, numbers, and results were generated while producing the PDF from the sources.
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83.990000 USD

Magnetic Resonance Brain Imaging: Modeling and Data Analysis Using R

by Karsten Tabelow, Joerg Polzehl
Paperback / softback
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This book reviews the state of the art in deep learning approaches to high-performance robust disease detection, robust and accurate organ segmentation in medical image computing (radiological and pathological imaging modalities), and the construction and mining of large-scale radiology databases. It particularly focuses on the application of convolutional neural networks, ...
Deep Learning and Convolutional Neural Networks for Medical Imaging and Clinical Informatics
This book reviews the state of the art in deep learning approaches to high-performance robust disease detection, robust and accurate organ segmentation in medical image computing (radiological and pathological imaging modalities), and the construction and mining of large-scale radiology databases. It particularly focuses on the application of convolutional neural networks, and on recurrent neural networks like LSTM, using numerous practical examples to complement the theory. The book's chief features are as follows: It highlights how deep neural networks can be used to address new questions and protocols, and to tackle current challenges in medical image computing; presents a comprehensive review of the latest research and literature; and describes a range of different methods that employ deep learning for object or landmark detection tasks in 2D and 3D medical imaging. In addition, the book examines a broad selection of techniques for semantic segmentation using deep learning principles in medical imaging; introduces a novel approach to text and image deep embedding for a large-scale chest x-ray image database; and discusses how deep learning relational graphs can be used to organize a sizable collection of radiology findings from real clinical practice, allowing semantic similarity-based retrieval.The intended reader of this edited book is a professional engineer, scientist or a graduate student who is able to comprehend general concepts of image processing, computer vision and medical image analysis. They can apply computer science and mathematical principles into problem solving practices. It may be necessary to have a certain level of familiarity with a number of more advanced subjects: image formation and enhancement, image understanding, visual recognition in medical applications, statistical learning, deep neural networks, structured prediction and image segmentation.
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157.490000 USD

Deep Learning and Convolutional Neural Networks for Medical Imaging and Clinical Informatics

Hardback
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This book presents the advances in super-resolution microscopy in physics and biomedical optics for nanoscale imaging. In the last decade, super-resolved fluorescence imaging has opened new horizons in improving the resolution of optical microscopes far beyond the classical diffraction limit, leading to the Nobel Prize in Chemistry in 2014. This ...
Label-Free Super-Resolution Microscopy
This book presents the advances in super-resolution microscopy in physics and biomedical optics for nanoscale imaging. In the last decade, super-resolved fluorescence imaging has opened new horizons in improving the resolution of optical microscopes far beyond the classical diffraction limit, leading to the Nobel Prize in Chemistry in 2014. This book represents the first comprehensive review of a different type of super-resolved microscopy, which does not rely on using fluorescent markers. Such label-free super-resolution microscopy enables potentially even broader applications in life sciences and nanoscale imaging, but is much more challenging and it is based on different physical concepts and approaches. A unique feature of this book is that it combines insights into mechanisms of label-free super-resolution with a vast range of applications from fast imaging of living cells to inorganic nanostructures. This book can be used by researchers in biological and medical physics. Due to its logically organizational structure, it can be also used as a teaching tool in graduate and upper-division undergraduate-level courses devoted to super-resolved microscopy, nanoscale imaging, microscopy instrumentation, and biomedical imaging.
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167.990000 USD

Label-Free Super-Resolution Microscopy

Hardback
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The recognition of oxidative stress as a major factor in health, aging, and disease has led to a surge in research aimed at uncovering effective countermeasures in the form of antioxidants. Unique in its two-fold protective function, alpha-lipoic acid has drawn unprecedented interest as a coenzyme in mitochondrial energy metabolism ...
Lipoic Acid: Energy Production, Antioxidant Activity and Health Effects
The recognition of oxidative stress as a major factor in health, aging, and disease has led to a surge in research aimed at uncovering effective countermeasures in the form of antioxidants. Unique in its two-fold protective function, alpha-lipoic acid has drawn unprecedented interest as a coenzyme in mitochondrial energy metabolism and as an antioxidant and cell redox modulator. Mounting data regarding its potential health benefits demands an authoritative, single-source reference to codify current knowledge and guide future research. A state-of-the-science compilation, Lipoic Acid follows the history of this potent coenzyme and the latest discoveries regarding the chemistry, biological action, and significance in energy production, antioxidant activity, and health. The book is divided into three sections: * Section I: Discovery and Molecular Structure reviews the early studies leading to the discovery of alpha-lipoic acid and explains the molecular structure, biosynthesis, and the characterization of lipoic acid and its chemical derivatives. * Section II: Metabolic Aspects describes in detail the human pharmacokinetics of alpha-lipoic acid including the lipoic acid-derived dehydrogenase complexes and their roles in energy metabolism. It also explains antioxidant activity and redox modulation and how lipoic acid induces Phase II detoxification enzymes through activation of Nrf2-dependent gene expression. * Section III Clinical Aspects discusses enzyme deficiency disorders and the effects of lipoic acid on insulin. It defines lipoic acid influence on signaling pathways and AMP-activated kinase, and considers the therapeutic implications for treatment of metabolic syndromes and the improvement of mitochondrial function by lipoic acid supplementation. Contributions from leading in
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78.700000 USD

Lipoic Acid: Energy Production, Antioxidant Activity and Health Effects

Paperback / softback
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This book introduces and reviews all of the currently available methods being used for computational electroencephalogram (EEG) analysis, from the fundamentals through to the state-of-the-art. The aim of the book is to help biomedical engineers and medical doctors who use EEG to better understand the methods and applications of computational ...
Computational EEG Analysis: Methods and Applications
This book introduces and reviews all of the currently available methods being used for computational electroencephalogram (EEG) analysis, from the fundamentals through to the state-of-the-art. The aim of the book is to help biomedical engineers and medical doctors who use EEG to better understand the methods and applications of computational EEG analysis from a single, well-organized resource. Following a brief introduction to the principles of EEG and acquisition techniques, the book is divided into two main sections. The first of these covers analysis methods, beginning with preprocessing, and then describing EEG spectral analysis, event-related potential analysis, source imaging and multimodal neuroimaging, and functional connectivity analysis. The following section covers application of EEG analysis to specific fields, including the diagnosis of psychiatric diseases and neurological disorders, brain-computer interfacing, and social neuroscience. Aimed at practicing medical specialists, engineers, researchers and advanced students, the book features contributions from world-renowned biomedical engineers working across a broad spectrum of computational EEG analysis techniques and EEG applications.
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115.490000 USD

Computational EEG Analysis: Methods and Applications

Paperback / softback
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This open access book provides a comprehensive overview of the application of the newest laser and microscope/ophthalmoscope technology in the field of high resolution imaging in microscopy and ophthalmology. Starting by describing High-Resolution 3D Light Microscopy with STED and RESOLFT, the book goes on to cover retinal and anterior segment ...
High Resolution Imaging in Microscopy and Ophthalmology: New Frontiers in Biomedical Optics
This open access book provides a comprehensive overview of the application of the newest laser and microscope/ophthalmoscope technology in the field of high resolution imaging in microscopy and ophthalmology. Starting by describing High-Resolution 3D Light Microscopy with STED and RESOLFT, the book goes on to cover retinal and anterior segment imaging and image-guided treatment and also discusses the development of adaptive optics in vision science and ophthalmology. Using an interdisciplinary approach, the reader will learn about the latest developments and most up to date technology in the field and how these translate to a medical setting. High Resolution Imaging in Microscopy and Ophthalmology - New Frontiers in Biomedical Optics has been written by leading experts in the field and offers insights on engineering, biology, and medicine, thus being a valuable addition for scientists, engineers, and clinicians with technical and medical interest who would like to understand the equipment, the applications and the medical/biological background. Lastly, this book is dedicated to the memory of Dr. Gerhard Zinser, co-founder of Heidelberg Engineering GmbH, a scientist, a husband, a brother, a colleague, and a friend.
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62.990000 USD

High Resolution Imaging in Microscopy and Ophthalmology: New Frontiers in Biomedical Optics

Hardback
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This book expands the debate on the future of science and technology at the Curious2018 - Future Insight Conference, held on the occasion of Merck's 350-year anniversary. In the respective chapters, some of the world's top scientists, managers and entrepreneurs explore breakthrough technologies and how they can be applied to ...
Curious2018: Future Insights in Science and Technology
This book expands the debate on the future of science and technology at the Curious2018 - Future Insight Conference, held on the occasion of Merck's 350-year anniversary. In the respective chapters, some of the world's top scientists, managers and entrepreneurs explore breakthrough technologies and how they can be applied to make a better world for humanity. Divided into three parts, the book begins with an introduction to the vision of the conference and to the importance of curiosity for innovation, while also exploring the latest scientific developments that are shaping the future of healthcare, medicine, the life and material sciences, digitalization and new ways of working together. In the second part, particular attention is paid to new therapies and diagnostics; here, readers will learn how synthetic biology and chemistry are being used to solve problems that are essential to the future of humanity. The role of in-silico research is also discussed. In the final part of the book, readers will find some thoughts on ethical principles guiding our application of science and technology to create a bright future for humanity. Given its interdisciplinary appeal, the book will inspire curiosity in a wide readership, from scholars and researchers to professionals with an interest in exploring the future of science and technology, solving the problems of today, and paving the way for a better tomorrow. Chapters 1, 2, 3 and 17 are available open access under a Creative Commons Attribution-NonCommercial 4.0 International License via link.springer.com.
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115.490000 USD

Curious2018: Future Insights in Science and Technology

Hardback
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Nucleic Acids as Gene Anticancer Drug Delivery Therapy highlights the most recent developments in cancer treatment using nucleic acids, nanoparticles and polymer nanoparticles for genomic nanocarriers as drug delivery, including promising opportunities for targeted and combination therapy. The development of a wide spectrum of nanoscale technologies is beginning to change ...
Nucleic Acids as Gene Anticancer Drug Delivery Therapy
Nucleic Acids as Gene Anticancer Drug Delivery Therapy highlights the most recent developments in cancer treatment using nucleic acids, nanoparticles and polymer nanoparticles for genomic nanocarriers as drug delivery, including promising opportunities for targeted and combination therapy. The development of a wide spectrum of nanoscale technologies is beginning to change the scientific landscape in terms of disease diagnosis, treatment, and prevention. This book presents the use of nanotechnology for medical applications, focusing on its use for anticancer drug delivery. Various intelligent drug delivery systems such as inorganic nanoparticles and polymer-based drug delivery are discussed. The use of smart drug delivery systems seems to be a promising approach for developing intelligent therapeutic systems for cancer immunotherapies and is discussed in detail along with nucleic acid-targeted drug delivery combination therapy for cancer. Nucleic Acids as Gene Anticancer Drug Delivery Therapy will be a useful reference for pharmaceutical scientists, pharmacologiests, and those involved in nanotechnology and cancer research.
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210.000000 USD

Nucleic Acids as Gene Anticancer Drug Delivery Therapy

by Loutfy H. Madkour
Paperback / softback
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This book contains contributions from computational biomechanics specialists who present and exchange opinions on the opportunities for applying their techniques to computer-integrated medicine, including computer-aided surgery and diagnostic systems. Computational Biomechanics for Medicine collects peer-reviewed chapters from the annual Computational Biomechanics for Medicine Workshop, in conjunction with the Medical Image ...
Computational Biomechanics for Medicine: Personalisation, Validation and Therapy
This book contains contributions from computational biomechanics specialists who present and exchange opinions on the opportunities for applying their techniques to computer-integrated medicine, including computer-aided surgery and diagnostic systems. Computational Biomechanics for Medicine collects peer-reviewed chapters from the annual Computational Biomechanics for Medicine Workshop, in conjunction with the Medical Image Computing and Computer Assisted Intervention [MICCAI] Society conference. The works are dedicated to research in the field of methods and applications of computational biomechanics to medical image analysis, image-guided surgery, surgical simulation, surgical intervention planning, disease diagnosis and prognosis, analysis of injury mechanisms, implant and prosthesis design, artificial organ design, and medical robotics. These chapters will appeal to a wide range of researchers and students within the fields of engineering and medicine, as well as those working in computational science.
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262.490000 USD

Computational Biomechanics for Medicine: Personalisation, Validation and Therapy

Hardback
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This book focuses on applications of micro CT, CBCT and CT in medicine and engineering, comprehensively explaining the basic principles of these techniques in detail, and describing their increasing use in the imaging field. It particularly highlights the scanning procedure, which represents the most crucial step in micro CT, and ...
Micro-computed Tomography (micro-CT) in Medicine and Engineering
This book focuses on applications of micro CT, CBCT and CT in medicine and engineering, comprehensively explaining the basic principles of these techniques in detail, and describing their increasing use in the imaging field. It particularly highlights the scanning procedure, which represents the most crucial step in micro CT, and discusses in detail the reconstruction process and the artifacts related to the scanning processes, as well as the imaging software used in analysis. Written by international experts, the book illustrates the application of micro CT in different areas, such as dentistry, medicine, tissue engineering, aerospace engineering, geology, material engineering, civil engineering and additive manufacturing. Covering different areas of application, the book is of interest not only to specialists in the respective fields, but also to broader audience of professionals working in the fields of imaging and analysis, as well as to students of the different disciplines.
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146.990000 USD

Micro-computed Tomography (micro-CT) in Medicine and Engineering

Hardback
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This book provides state-of-the-art information on advances in the diagnosis and treatment of pulmonary aspergillosis to help specialists and clinical practitioners make appropriate decisions concerning the management of patients with this condition. The incidence of pulmonary aspergillosis has increased steadily due to the widespread use of broad-spectrum antibiotics, cytotoxic drugs, ...
Pulmonary Aspergillosis: Diagnosis and Cases
This book provides state-of-the-art information on advances in the diagnosis and treatment of pulmonary aspergillosis to help specialists and clinical practitioners make appropriate decisions concerning the management of patients with this condition. The incidence of pulmonary aspergillosis has increased steadily due to the widespread use of broad-spectrum antibiotics, cytotoxic drugs, immunosuppressive agents and adrenal hormones, as well as the growing number of organ transplantations and AIDS patients. The book discusses various aspects of the disease, including its history, characteristics, laboratory examination, imaging features, clinical diagnosis, differential diagnosis and treatment principles, and also presents illustrated case studies. Focusing on different characteristics in imaging and pathology, and addressing diagnostic difficulties in-depth, this clinical reference work brings together recent clinical investigations to making it a valuable resource for practitioners in the fields of respiratory and infectious diseases, oncology, intensive care, diagnostic imaging, pathology and microbiology.
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178.490000 USD

Pulmonary Aspergillosis: Diagnosis and Cases

Hardback
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This book introduces the latest optical coherence tomography (OCT) imaging and computerized automatic image analysis techniques, and their applications in the diagnosis and treatment of retinal diseases. Discussing the basic principles and the clinical applications of OCT imaging, OCT image preprocessing, as well as the automatic detection and quantitative analysis ...
Retinal Optical Coherence Tomography Image Analysis
This book introduces the latest optical coherence tomography (OCT) imaging and computerized automatic image analysis techniques, and their applications in the diagnosis and treatment of retinal diseases. Discussing the basic principles and the clinical applications of OCT imaging, OCT image preprocessing, as well as the automatic detection and quantitative analysis of retinal anatomy and pathology, it includes a wealth of clinical OCT images, and state-of-the-art research that applies novel image processing, pattern recognition and machine learning methods to real clinical data. It is a valuable resource for researchers in both medical image processing and ophthalmic imaging.
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204.55 USD

Retinal Optical Coherence Tomography Image Analysis

Hardback
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