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There is an ever-expanding range of implants used in Orthopaedic Surgery. Nearly 200,000 joint replacement procedures are done in UK every year. The performance of these implants is assessed on radiographs. This is of interest to Orthopaedic surgeons and Radiologists alike. Information on interpretation of these radiographs is not readily ...
Radiology of Orthopedic Implants
There is an ever-expanding range of implants used in Orthopaedic Surgery. Nearly 200,000 joint replacement procedures are done in UK every year. The performance of these implants is assessed on radiographs. This is of interest to Orthopaedic surgeons and Radiologists alike. Information on interpretation of these radiographs is not readily available in an easily readable format. This book will assist both trainees and practicing orthopedic surgeons and radiologists in assessing the radiologic appearance of implants and their potential for future performance.
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187.68 USD

Radiology of Orthopedic Implants

Hardback
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The book offers a comprehensive and up-to-date guide to the cutting edge arthroscopic transosseous techniques for the treatment of rotator cuff tears, which are gradually taking over from the common open surgical approach, defined as the gold standard for RCR. With the help of numerous figures, it presents step by ...
Arthroscopic Transosseous Rotator Cuff Repair: Tips and Tricks
The book offers a comprehensive and up-to-date guide to the cutting edge arthroscopic transosseous techniques for the treatment of rotator cuff tears, which are gradually taking over from the common open surgical approach, defined as the gold standard for RCR. With the help of numerous figures, it presents step by step a novel all-arthroscopic anchorless transosseous suture technique that is less invasive and easier to perform. After discussing the etiopathogenesis, histopathology and radiological classification of rotator cuff tears, the book reviews all possible arthroscopic procedures and explores in detail suture management, describing single and double tunnel options. It also examines the complications and post-operative rehabilitation and imaging, while the closing chapter addresses the economic aspects of daily use. Intended primarily for arthroscopic surgeons interested in the field of shoulder joint repair, this exhaustive guide is also a valuable resource for residents and shoulder specialists.
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114.450000 USD

Arthroscopic Transosseous Rotator Cuff Repair: Tips and Tricks

by Marcello Osimani, Alessandro Castagna, Claudio Chillemi
Mixed media product
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All hollow organs, such as blood vessels, the gastrointestinal tract, airways, male and female reproductive systems, and the urinary bladder are primarily composed of smooth muscle. Such organs regulate flow, propulsion and mixing of luminal contents and storage by the contraction and relaxation of smooth muscle cells. Smooth muscle cells ...
Signal Transduction and Smooth Muscle
All hollow organs, such as blood vessels, the gastrointestinal tract, airways, male and female reproductive systems, and the urinary bladder are primarily composed of smooth muscle. Such organs regulate flow, propulsion and mixing of luminal contents and storage by the contraction and relaxation of smooth muscle cells. Smooth muscle cells respond to numerous inputs, including pressure, shear stress, intrinsic and extrinsic innervation, hormones and other circulating molecules, as well as autocrine and paracrine factors. This book is a review of smooth muscle cell regulation in the cardiovascular, reproductive, GI, and other organ systems with emphasis on calcium and receptor signaling.
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168.92 USD

Signal Transduction and Smooth Muscle

Hardback
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This second edition of Protein Purification provides a guide to the major chromatographic techniques, including non-affinity absorption techniques, affinity procedures, non-absorption techniques and methods for monitoring protein purity. The new edition of the book has been organized to encourage incremental learning about the topic, starting with the properties of water, ...
Protein Purification
This second edition of Protein Purification provides a guide to the major chromatographic techniques, including non-affinity absorption techniques, affinity procedures, non-absorption techniques and methods for monitoring protein purity. The new edition of the book has been organized to encourage incremental learning about the topic, starting with the properties of water, progressing through the characteristics of amino acids and proteins which relate to the purification process. There is an overview of protein strategy and equipment, followed by discussions and examples of each technique and their applications. The basic theory and simple explanations given in Protein Purification make it an ideal handbook for final year undergraduates, and postgraduates, who are conducting research projects. It will also be a useful guide to more experienced researchers who need a good overview of the techniques and products used in protein purification. Key Features * Guide to the major techniques used in protein purification * Includes flowcharts to help the reader slect the best purification strategy * Contains step-by-step protocols that guide the reader through each technique and its use * Includes exercises and solutions
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68.25 USD

Protein Purification

by Philip Bonner
Paperback / softback
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This book focuses on the envelope of Gram-positive bacteria including its composition, the latest discoveries in the mechanisms behind its assembly, and its role in pathogenesis. Furthermore, new applications in biotechnology and vaccine development involving these bacteria are discussed in detail. This concise volume consists of eleven chapters by prominent ...
Protein and Sugar Export and Assembly in Gram-positive Bacteria
This book focuses on the envelope of Gram-positive bacteria including its composition, the latest discoveries in the mechanisms behind its assembly, and its role in pathogenesis. Furthermore, new applications in biotechnology and vaccine development involving these bacteria are discussed in detail. This concise volume consists of eleven chapters by prominent experts in the field, which review the latest findings and current state of knowledge on a range of diverse yet interlinked aspects. This book is written for all researchers, clinicians and technicians engaged in basic or applied science projects on Gram-positive bacteria.
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230.990000 USD

Protein and Sugar Export and Assembly in Gram-positive Bacteria

Paperback / softback
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This book introduces and reviews all of the currently available methods being used for computational electroencephalogram (EEG) analysis, from the fundamentals through to the state-of-the-art. The aim of the book is to help biomedical engineers and medical doctors who use EEG to better understand the methods and applications of computational ...
Computational EEG Analysis: Methods and Applications
This book introduces and reviews all of the currently available methods being used for computational electroencephalogram (EEG) analysis, from the fundamentals through to the state-of-the-art. The aim of the book is to help biomedical engineers and medical doctors who use EEG to better understand the methods and applications of computational EEG analysis from a single, well-organized resource. Following a brief introduction to the principles of EEG and acquisition techniques, the book is divided into two main sections. The first of these covers analysis methods, beginning with preprocessing, and then describing EEG spectral analysis, event-related potential analysis, source imaging and multimodal neuroimaging, and functional connectivity analysis. The following section covers application of EEG analysis to specific fields, including the diagnosis of psychiatric diseases and neurological disorders, brain-computer interfacing, and social neuroscience. Aimed at practicing medical specialists, engineers, researchers and advanced students, the book features contributions from world-renowned biomedical engineers working across a broad spectrum of computational EEG analysis techniques and EEG applications.
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157.490000 USD

Computational EEG Analysis: Methods and Applications

Hardback
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Simulating blood cells for biomedical applications is a challenging goal. Whether you want to investigate blood flow behavior on the cell scale, or use a blood cell model for fast computational prototyping in microfluidics, Computational Blood Cell Mechanics will help you get started, and show you the path forward. The ...
Computational Blood Cell Mechanics: Road Towards Models and Biomedical Applications
Simulating blood cells for biomedical applications is a challenging goal. Whether you want to investigate blood flow behavior on the cell scale, or use a blood cell model for fast computational prototyping in microfluidics, Computational Blood Cell Mechanics will help you get started, and show you the path forward. The text presents a step-by-step approach to cell model building that can be adopted when developing and validating models for biomedical applications, such as filtering and sorting cells, or examining flow and deformations of individual cells under various conditions. It starts with basic building-blocks that, together, model the red blood cell membrane according to its physical properties, before moving on to discuss several issues that may pose problems along the way, and finally leads to suggestions on how to set up computational experiments. More details available at www.compbloodcell.eu
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156.98 USD

Computational Blood Cell Mechanics: Road Towards Models and Biomedical Applications

by Iveta Jancigova, Ivan Cimrak
Hardback
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This book covers the most recent advances in using nanoparticles for biomedical imaging, including magnetic resonance imaging (MRI), magnetic particle imaging (MPI), nuclear medicine, ultrasound (US) imaging, computed tomography (CT), and optical imaging. Topics include nanoparticles for MRI and MPI, siRNA delivery, theranostic nanoparticles for PET imaging of drug delivery, ...
Design and Applications of Nanoparticles in Biomedical Imaging
This book covers the most recent advances in using nanoparticles for biomedical imaging, including magnetic resonance imaging (MRI), magnetic particle imaging (MPI), nuclear medicine, ultrasound (US) imaging, computed tomography (CT), and optical imaging. Topics include nanoparticles for MRI and MPI, siRNA delivery, theranostic nanoparticles for PET imaging of drug delivery, US nanoparticles for imaging drug delivery, inorganic nanoparticles for targeted CT imaging, and quantum dots for optical imaging. This book serves as a valuable resource for the fundamental science of diagnostic nanoparticles and their interactions with biological targets, providing a practical handbook for improved detection of disease and its clinical implementation.
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230.990000 USD

Design and Applications of Nanoparticles in Biomedical Imaging

Paperback / softback
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While systems biology and pharmacodynamics have evolved in parallel, there are significant interrelationships that can enhance drug discovery and enable optimized therapy for each patient. Systems pharmacology is the relatively new discipline that is the interface between these two methods. This book is the first to cover the expertise from ...
Systems Pharmacology and Pharmacodynamics
While systems biology and pharmacodynamics have evolved in parallel, there are significant interrelationships that can enhance drug discovery and enable optimized therapy for each patient. Systems pharmacology is the relatively new discipline that is the interface between these two methods. This book is the first to cover the expertise from systems biology and pharmacodynamics researchers, describing how systems pharmacology may be developed and refined further to show practical applications in drug development. There is a growing awareness that pharmaceutical companies should reduce the high attrition in the pipeline due to insufficient efficacy or toxicity found in proof-of-concept and/or Phase II studies. Systems Pharmacology and Pharmacodynamics discusses the framework for integrating information obtained from understanding physiological/pathological pathways (normal body function system vs. perturbed system due to disease) and pharmacological targets in order to predict clinical efficacy and adverse events through iterations between mathematical modeling and experimentation.
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262.490000 USD

Systems Pharmacology and Pharmacodynamics

Paperback / softback
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This thesis describes the authors' pioneering efforts in the conceptualization and implementation of combined platinum-based immuno-chemotherapeutics, which represent a significant paradigm shift from the conventional approach of directly targeting cancer. The work described has opened up a rich and largely unexplored area for platinum-based drug design, and ultimately paves the ...
Rethinking Platinum Anticancer Drug Design: Towards Targeted and Immuno-chemotherapeutic Approaches
This thesis describes the authors' pioneering efforts in the conceptualization and implementation of combined platinum-based immuno-chemotherapeutics, which represent a significant paradigm shift from the conventional approach of directly targeting cancer. The work described has opened up a rich and largely unexplored area for platinum-based drug design, and ultimately paves the way for superior immuno-chemotherapeutics with better clinical outcome for patients. Historically, the contribution of the immune system to chemotherapy outcomes has been neglected, as anticancer drugs were believed to be immunosuppressive. However, this has been challenged by contemporary evidence suggesting that many chemotherapeutics, including platinum-based agents, stimulate the innate and/or adaptive immune system and that these secret allies contribute tangibly to clinical outcomes. A multi-pronged immuno-chemotherapeutic approach not only shrinks tumors, but more importantly, reactivate dormant immune responses to malignancies, eliminating residual cancer cells.
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157.490000 USD

Rethinking Platinum Anticancer Drug Design: Towards Targeted and Immuno-chemotherapeutic Approaches

by Daniel Yuan Qiang Wong
Hardback
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This volume presents readers with the latest techniques to study nanoimaging and nanoprobing in application to a broad range of biological systems. The chapters in this book are divided into five parts, and cover topics such as imaging and probing of biomacromolecules including high-speed imaging and probing with AFM; probing ...
Nanoscale Imaging: Methods and Protocols
This volume presents readers with the latest techniques to study nanoimaging and nanoprobing in application to a broad range of biological systems. The chapters in this book are divided into five parts, and cover topics such as imaging and probing of biomacromolecules including high-speed imaging and probing with AFM; probing chromatin structure with magnetic tweezers; and fluorescence correlation spectroscopy on genomic DNA in living cells. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and through, Nanoscale Imaging: Methods and Protocols is a valuable resource for anyone interested in learning more about this developing and expanding field.
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293.990000 USD

Nanoscale Imaging: Methods and Protocols

Hardback
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Notable experts in the field of neuroimaging provide comprehensive overviews of advances in functional and structural aspects of both common and uncommon brain disorders. Functional imaging is evolving quickly but researchers and clinicians do not always have a strong understanding of the fundamental basis of the imaging techniques that they ...
The Neuroimaging of Brain Diseases: Structural and Functional Advances
Notable experts in the field of neuroimaging provide comprehensive overviews of advances in functional and structural aspects of both common and uncommon brain disorders. Functional imaging is evolving quickly but researchers and clinicians do not always have a strong understanding of the fundamental basis of the imaging techniques that they use. By focusing on both structure and function this book will provide a strong foundation for emerging developments in the field.
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188.990000 USD

The Neuroimaging of Brain Diseases: Structural and Functional Advances

Hardback
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This book is a practical guide to chest CTs for non-radiologists. A succinct and focused book, Chest CT for Non-Radiologists is designed to give the reader just the level of information they need to know. Chapters begin with the basics of a chest CT, including when they are necessary and ...
Chest CT for Non-Radiologists: A Practical Guide
This book is a practical guide to chest CTs for non-radiologists. A succinct and focused book, Chest CT for Non-Radiologists is designed to give the reader just the level of information they need to know. Chapters begin with the basics of a chest CT, including when they are necessary and the basic procedures, so physicians and medical professionals can best counsel their patients. The book then moves into various parts of the chest and the common diseases and presentations that would be found in a chest CT (lung fibrosis, pulmonary nodules, etc.). It teaches the reader what to look for and how to provide the most accurate and effective diagnosis for their patients. There are also several de-identified CT scans that allow the reader to test his or her skills. This is an ideal resource for non-radiologist physicians -- including pulmonologists, internal medicine physicians, emergency medicine physicians, and critical care specialists, residents, and medical students -- to learn the basics of the chest CT and thereby provide optimal care for their patients.
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89.240000 USD

Chest CT for Non-Radiologists: A Practical Guide

by Monica A. Pernia M., Ronaldo Collo Go, Mary M. Salvatore
Paperback
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This textbook offers a comprehensive guide to interventional radiology (IR) for medical students, residents, nurse practitioners, physician assistants, and fellows. IR is constantly evolving to meet the growing demands of patient care by applying cutting-edge technology to minimally invasive image-guided procedures. A dynamic specialty, interventional radiology has gained significant traction ...
IR Playbook: A Comprehensive Introduction to Interventional Radiology
This textbook offers a comprehensive guide to interventional radiology (IR) for medical students, residents, nurse practitioners, physician assistants, and fellows. IR is constantly evolving to meet the growing demands of patient care by applying cutting-edge technology to minimally invasive image-guided procedures. A dynamic specialty, interventional radiology has gained significant traction and interest in recent years, with combined IR/DR residencies rising to meet the increasing demand. This book addresses this growing need for a reference in IR, allowing students to gain a solid foundation to prepare them for their careers. The book is divided into two main sections, with many images and key point boxes throughout that offer high-yield pearls along with the specific How To's necessary for practice. The first section is designed to give readers an introduction to IR, including radiation safety, commonly used devices, patient care, and anatomy. The second portion divides into sections covering major body areas, diseases, conditions, and interventions. These chapters cover procedures including pathophysiology, indications for treatment, as well as alternative treatments before delving into interventional therapy. IR Playbook gives medical students, residents, and trainees a full perspective of interventional radiology.
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156.450000 USD

IR Playbook: A Comprehensive Introduction to Interventional Radiology

Hardback
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This book focuses on the lobar anatomy of the breast and on the sick lobe concept - a novel theory of breast cancer development that is gaining ever wider acceptance - and explores their significance for innovative surgical treatment. Special attention is paid to the role of ductal echography, a ...
Lobar Approach to Breast Ultrasound
This book focuses on the lobar anatomy of the breast and on the sick lobe concept - a novel theory of breast cancer development that is gaining ever wider acceptance - and explores their significance for innovative surgical treatment. Special attention is paid to the role of ductal echography, a technique capable of clearly depicting the structures of cancer in relation to the structures of the sick lobe. Having established a sound theoretical and practical basis through detailed coverage and correlation of anatomy, pathology, and imaging appearances, the book goes on to describe a revolutionary surgical approach particularly suitable for the treatment of multifocal and multicentric breast carcinomas. Such tumors account for more than a third of all cases of breast carcinoma and are often treated by mastectomy. The proposed new breast-conserving technique yields excellent cosmetic results and entails a very low risk of recurrence. The book will appeal to a wide readership, including radiologists, surgeons, oncologists, pathologists, as well as residents.
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114.450000 USD

Lobar Approach to Breast Ultrasound

Hardback
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This book gives a state-of-the-art view by recognized researchers of the nanotechnologies required for future integrated systems leading to innovations in energy, the environment, and biotechnologies. Nanostructures that would be difficult to form using the current semiconductor technology will be realized using a combination of bottom-up and top-down processes, including ...
Intelligent Nanosystems for Energy, Information and Biological Technologies
This book gives a state-of-the-art view by recognized researchers of the nanotechnologies required for future integrated systems leading to innovations in energy, the environment, and biotechnologies. Nanostructures that would be difficult to form using the current semiconductor technology will be realized using a combination of bottom-up and top-down processes, including hybrid nanostructures made of inorganic and organic/biological materials. Bio-sensing, imaging, and cell or molecular manipulation are discussed in Chapters 2-7. The acquisition of basic knowledge on the cellular level will lead to curing serious diseases. Also, nanofabrication technologies, discussed in Chapters 8-15, will lead to next-generation solar cells, secondary batteries, and advanced electronic circuits using nanostructured materials, thus providing solutions for serious energy and environment issues. Prospective readers of this book include graduate students as well as researchers and engineers working in this field.
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188.990000 USD

Intelligent Nanosystems for Energy, Information and Biological Technologies

Paperback / softback
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This book highlights the latest advances in functional micro/nano imaging probes and their applications for biomedical imaging and therapy. Given the rapid emergence of transdisciplinary research and applications in materials, chemical probes and translational medicine in recent years, scientists in these areas are expected to keep up to date on ...
Advances in Functional Micro-/Nanoimaging Probes
This book highlights the latest advances in functional micro/nano imaging probes and their applications for biomedical imaging and therapy. Given the rapid emergence of transdisciplinary research and applications in materials, chemical probes and translational medicine in recent years, scientists in these areas are expected to keep up to date on the latest technologies and advances to promote comprehensive innovations. Addressing this need, the book presents recently introduced features, emerging techniques, and new strategies, complemented by detailed illustrations. Covering the status quo and offering an outlook on the future, it benefits all readers with an interest in functional materials, especially micro/nano imaging materials for biomedical imaging applications, providing them with both vital updates and inspiration for their own research.
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146.990000 USD

Advances in Functional Micro-/Nanoimaging Probes

Hardback
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The interactions of cells with their surrounding extracellular matrix (ECM) plays a pivotal role in driving normal cell behavior, from development to tissue differentiation and function. At the cellular level, organ homeostasis depends on a productive communication between cells and ECM, which eventually leads to the normal phenotypic repertoire that ...
Discoidin Domain Receptors in Health and Disease
The interactions of cells with their surrounding extracellular matrix (ECM) plays a pivotal role in driving normal cell behavior, from development to tissue differentiation and function. At the cellular level, organ homeostasis depends on a productive communication between cells and ECM, which eventually leads to the normal phenotypic repertoire that characterize each cell type in the organism. A failure to establish these normal interactions and to interpret the cues emanating from the ECM is one of the major causes in abnormal development and the pathogenesis of multiple diseases. To recognize and act upon the biophysical signals that are generated by the cross talk between cells and ECM, the cells developed specific receptors, among them a unique set of receptor tyrosine kinases (RTKs), known as the Discoidin Domain Receptors (DDRs). The DDRs are the only RTKs that specifically bind to and are activated by collagen, a major protein component of the ECM. Hence, the DDRs are part of the signaling networks that translate information from the ECM, and thus they are key regulators of cell-matrix interactions. Under physiological conditions, DDRs control cell and tissue homeostasis by acting on collagen sensors; transducing signals that regulate cell polarity, tissue morphogenesis, cell differentiation, and collagen deposition. DDRs play a key role in diseases that are characterized by dysfunction of the stromal component, which lead to abnormal collagen deposition and the resulting fibrotic response that disrupt normal organ function in disease of the cardiovascular system, lungs and kidneys, just to mention a few. In cancer, DDRs are hijacked by tumor and stromal cells to disrupt normal cell-collagen communication and initiate pro-oncogenic programs. Importantly, several cancer types exhibit DDR mutations, which are thought to alter receptor function, and contribute to cancer progression. Therefore, the strong causative association between altered RTK function and disease it is been translated today in the development of specific tyrosine kinase inhibitors targeting DDRs for various disease conditions. In spite of the accumulating evidence highlighting the importance of DDRs in health and diseases, there is still much to learn about these unique RTKs, as of today there is a lack in the medical literature of a book dedicated solely to DDRs. This is the first comprehensive volume dedicated to DDRs, which will fill a gap in the field and serve those interested in the scientific community to learn more about these important receptors in health and disease.
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230.990000 USD

Discoidin Domain Receptors in Health and Disease

Paperback / softback
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This book highlights the impact of nutrients on early placentation processes and their relevance for fetal growth and pregnancy outcome. The role of maternal nutrition on fetal growth and development has been evidenced in many epidemiological studies that included infamous Dutch famine, Helsinki Birth cohort and others. Fetal programming hypothesis ...
Early Nutrition and Lifestyle Factors: Effects on First Trimester Placenta
This book highlights the impact of nutrients on early placentation processes and their relevance for fetal growth and pregnancy outcome. The role of maternal nutrition on fetal growth and development has been evidenced in many epidemiological studies that included infamous Dutch famine, Helsinki Birth cohort and others. Fetal programming hypothesis states that the nutritional and other environmental conditions under which an individual develops from pre-conception to birth has a major impact on the future health of the newborn child. The developmental environment of the fetus is primarily dependent on two major factors that are maternal nutritional state (excess/low/imbalance) and placental function. Placentation is characterized by the extensive remodeling of the maternal uterine vasculature producing low-resistance blood vessels that facilitate the exchange of nutrients and wastes between the mother and the fetus. Cellular and molecular mechanisms involved in human placental blood vessel formation, which are now well established, are discussed.
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209.990000 USD

Early Nutrition and Lifestyle Factors: Effects on First Trimester Placenta

by Sanjay Basak, Asim K. Duttaroy
Paperback / softback
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The Computational Biomechanics for Medicine titles provide an opportunity for specialists in computational biomechanics to present their latest methodologies and advancements. This volume comprises eighteen of the newest approaches and applications of computational biomechanics, from researchers in Australia, New Zealand, USA, UK, Switzerland, Scotland, France and Russia. Some of the ...
Computational Biomechanics for Medicine: Imaging, Modeling and Computing
The Computational Biomechanics for Medicine titles provide an opportunity for specialists in computational biomechanics to present their latest methodologies and advancements. This volume comprises eighteen of the newest approaches and applications of computational biomechanics, from researchers in Australia, New Zealand, USA, UK, Switzerland, Scotland, France and Russia. Some of the interesting topics discussed are: tailored computational models; traumatic brain injury; soft-tissue mechanics; medical image analysis; and clinically-relevant simulations. One of the greatest challenges facing the computational engineering community is to extend the success of computational mechanics to fields outside traditional engineering, in particular to biology, the biomedical sciences, and medicine. We hope the research presented within this book series will contribute to overcoming this grand challenge.
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262.490000 USD

Computational Biomechanics for Medicine: Imaging, Modeling and Computing

Paperback / softback
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Artificial organs may be considered as small-scale process plants, in which heat, mass and momentum transfer operations and, possibly, chemical transformations are carried out. This book proposes a novel analysis of artificial organs based on the typical bottom-up approach used in process engineering. Starting from a description of the fundamental ...
Artificial Organ Engineering
Artificial organs may be considered as small-scale process plants, in which heat, mass and momentum transfer operations and, possibly, chemical transformations are carried out. This book proposes a novel analysis of artificial organs based on the typical bottom-up approach used in process engineering. Starting from a description of the fundamental physico-chemical phenomena involved in the process, the whole system is rebuilt as an interconnected ensemble of elemental unit operations. Each artificial organ is presented with a short introduction provided by expert clinicians. Devices commonly used in clinical practice are reviewed and their performance is assessed and compared by using a mathematical model based approach. Whilst mathematical modelling is a fundamental tool for quantitative descriptions of clinical devices, models are kept simple to remain focused on the essential features of each process. Postgraduate students and researchers in the field of chemical and biomedical engineering will find that this book provides a novel and useful tool for the analysis of existing devices and, possibly, the design of new ones. This approach will also be useful for medical researchers who want to get a deeper insight into the basic working principles of artificial organs.
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178.490000 USD

Artificial Organ Engineering

by Luca Turchetti, Vincenzo Piemonte, Luigi Marrelli, Maria Cristina Annesini
Paperback / softback
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With a focus on anatomy and sonoantomy, this beautifully illustrated updated edition captures the latest advances in the rapidly growing field of ultrasound-guided pain medicine and MSK procedures. This atlas is divided into seven sections that provide an overview and focus on interventional approaches and advancements. Authored by international experts, ...
Atlas of Ultrasound-Guided Procedures in Interventional Pain Management
With a focus on anatomy and sonoantomy, this beautifully illustrated updated edition captures the latest advances in the rapidly growing field of ultrasound-guided pain medicine and MSK procedures. This atlas is divided into seven sections that provide an overview and focus on interventional approaches and advancements. Authored by international experts, each clinical chapter features a maximal number of instructive illustrations and sonograms and provides a description of sonoanatomy, instructions on performing the procedure and how to confirm appropriate needle placement. This book will help encourage and stimulate physicians to master approaches in interventional MSK and pain management.
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261.450000 USD

Atlas of Ultrasound-Guided Procedures in Interventional Pain Management

Hardback
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This book is written for researchers, undergraduate students and postgraduate students, physicians and traditional medicine practitioners who develop research in the field of neurosciences, phytochemistry and ethnopharmacology or can be useful for their practice. Topics discussed include the description of depression, its biochemical causes, the targets of antidepressant drugs, animal ...
Herbal Medicine in Depression: Traditional Medicine to Innovative Drug Delivery
This book is written for researchers, undergraduate students and postgraduate students, physicians and traditional medicine practitioners who develop research in the field of neurosciences, phytochemistry and ethnopharmacology or can be useful for their practice. Topics discussed include the description of depression, its biochemical causes, the targets of antidepressant drugs, animal and cell models commonly used in the research of this pathology, medicinal plants and bioactive compounds with antidepressant activity used in traditional medicine, advances in nanotechnology for drug delivery to the brain and finally the future challenges for researchers studying this pathology.
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262.490000 USD

Herbal Medicine in Depression: Traditional Medicine to Innovative Drug Delivery

Paperback / softback
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This volume comprises of 21 selected chapters, including two overview chapters devoted to abdominal imaging in clinical applications supported computer aided diagnosis approaches as well as different techniques for solving the pectoral muscle extraction problem in the preprocessing part of the CAD systems for detecting breast cancer in its early ...
Medical Imaging in Clinical Applications: Algorithmic and Computer-Based Approaches
This volume comprises of 21 selected chapters, including two overview chapters devoted to abdominal imaging in clinical applications supported computer aided diagnosis approaches as well as different techniques for solving the pectoral muscle extraction problem in the preprocessing part of the CAD systems for detecting breast cancer in its early stage using digital mammograms. The aim of this book is to stimulate further research in medical imaging applications based algorithmic and computer based approaches and utilize them in real-world clinical applications. The book is divided into four parts, Part-I: Clinical Applications of Medical Imaging, Part-II: Classification and clustering, Part-III: Computer Aided Diagnosis (CAD) Tools and Case Studies and Part-IV: Bio-inspiring based Computer Aided diagnosis techniques.
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262.490000 USD

Medical Imaging in Clinical Applications: Algorithmic and Computer-Based Approaches

Paperback / softback
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This book provides a concise yet comprehensive source of information on the classification, evaluation, diagnosis, and management of vascular lesions of the orbit and face. It highlights recent technological innovations and new treatments that have significantly improved the ability to accurately evaluate and successfully treat these lesions with reduced complications. ...
Vascular Lesions of the Orbit and Face: Imaging and Management
This book provides a concise yet comprehensive source of information on the classification, evaluation, diagnosis, and management of vascular lesions of the orbit and face. It highlights recent technological innovations and new treatments that have significantly improved the ability to accurately evaluate and successfully treat these lesions with reduced complications. Some of these advances include new imaging modalities, intravascular and intralesional treatment approaches, photodynamic therapy, and additional medical therapies. Many of these advances have led to paradigm shifts in the understanding and management of vascular lesions of the orbit and face. This book, written by experts in the fields of ophthalmology, dermatology, diagnostic and interventional radiology, and oculoplastic surgery, features structured, in-depth chapters that can also be quickly consulted as a reference guide. It is an excellent resource for those in training as well as seasoned practitioners wishing to acquaint themselves with the newest diagnostic and treatment techniques for orbital vascular lesions.
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125.990000 USD

Vascular Lesions of the Orbit and Face: Imaging and Management

Paperback / softback
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This book offers an overview of our current understanding of host defense peptides and their potential for clinical applications as well as some of the obstacles to this. The chapters, written by leading experts in the field, detail the number and diversity of host defense peptides, and discuss the therapeutic ...
Host Defense Peptides and Their Potential as Therapeutic Agents
This book offers an overview of our current understanding of host defense peptides and their potential for clinical applications as well as some of the obstacles to this. The chapters, written by leading experts in the field, detail the number and diversity of host defense peptides, and discuss the therapeutic potential not only of antibacterial, but also of antifungal, antiviral, plant antimicrobial and anticancer host defense peptides. The authors provide new insights into their mechanisms of action and their immunomodulatory properties, and review recent advances in the design of novel therapeutic molecules. Lastly, their potential to prevent preterm births and Staphylococcus aureus infections is highlighted. The book is of interest to researchers, industry and clinicians alike.
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209.990000 USD

Host Defense Peptides and Their Potential as Therapeutic Agents

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This thesis reports studies on the substrate specificity of crucial ketosynthase (KS) domains from trans-AT Polyketide Synthases (PKSs). Using a combination of electrospray ionisation-mass spectrometry (ESI-MS) and simple N-acetyl cysteamine (SNAC) substrate mimics, the specificity of a range of KS domains from the bacillaene and psymberin PKSs have been succsessfully ...
Using Mass Spectrometry for Biochemical Studies on Enzymatic Domains from Polyketide Synthases
This thesis reports studies on the substrate specificity of crucial ketosynthase (KS) domains from trans-AT Polyketide Synthases (PKSs). Using a combination of electrospray ionisation-mass spectrometry (ESI-MS) and simple N-acetyl cysteamine (SNAC) substrate mimics, the specificity of a range of KS domains from the bacillaene and psymberin PKSs have been succsessfully studied with regard to the initial acylation step of KS-catalysis. In addition, the ability to alter the substrate tolerance of KS domains by simple point mutations in the active site has been demonstrated. A series of acyl-ACPs have been synthesised using a novel methodology and employed to probe the substrate specificity of both KS domains and the previously uncharcterised acyl hydrolase domain, PedC. KS-catalysed chain elongation reactions have also been conducted and monitored by ESI-MS/MS. All KS domains studied exhibited higher substrate specificity at the elongation step than in the preceeding acylation step. Furthermore, a mechanism of reversible acylation is proposed using the PsyA ACP1-KS1 di-domain. The findings in this thesis provide important insights into mechanisms of KS specificity and show that mutagenesis can be used to expand the repertoire of acceptable substrates for future PKS engineering.
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146.990000 USD

Using Mass Spectrometry for Biochemical Studies on Enzymatic Domains from Polyketide Synthases

by Matthew Jenner
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This detailed volume includes a rich variety of applications using various instrumentations, probes, disease models, and targets in order to account for the multidisciplinary nature of the use of in vivo fluorescence imagine. The book also includes chapters on the emerging fields of cell tracking, image-guided treatment, and fluorescence imaging ...
In Vivo Fluorescence Imaging: Methods and Protocols
This detailed volume includes a rich variety of applications using various instrumentations, probes, disease models, and targets in order to account for the multidisciplinary nature of the use of in vivo fluorescence imagine. The book also includes chapters on the emerging fields of cell tracking, image-guided treatment, and fluorescence imaging in the second NIR window, as well as protocols for evaluation methods before and after in vivo imaging. Written for the highly successful Methods in Molecular Biology series, chapters include brief introductions to their respective topics, lists of the necessary materials and reagents, step-by-step readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, In Vivo Fluorescence Imaging: Methods and Protocols serves as a valuable reference for researchers from numerous fields who wish to become more familiar with in vivo fluorescence imaging techniques.
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178.490000 USD

In Vivo Fluorescence Imaging: Methods and Protocols

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This thesis focuses on the development of efficient and scalable total syntheses of natural products that can be used as preferred scaffolds for anti-infective drug discovery. It describes the total synthesis of two classes of antimicrobial non-ribosomal peptides (NRPs) - teixobactin and the skyllamycins - with subsequent biological evaluation. The ...
Total Synthesis of Natural Products with Antimicrobial Activity
This thesis focuses on the development of efficient and scalable total syntheses of natural products that can be used as preferred scaffolds for anti-infective drug discovery. It describes the total synthesis of two classes of antimicrobial non-ribosomal peptides (NRPs) - teixobactin and the skyllamycins - with subsequent biological evaluation. The first part describes the first total synthesis of teixobactin by means of a solid-phase peptide synthesis-macrolactamisation approach, yielding a synthetic natural product that can combat a number of clinically relevant Gram-positive bacterial pathogens. The second part describes the first total synthesis of skyllamycins A-C, a family of structurally complex cyclic NRPs, which inhibit the growth of the Pseudomonas aeruginosa biofilms that are responsible for significant mortality among cystic fibrosis patients.
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167.990000 USD

Total Synthesis of Natural Products with Antimicrobial Activity

by Andrew Giltrap
Hardback
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This book presents a detailed review of the state of the art in deep learning approaches for semantic object detection and segmentation in medical image computing, and large-scale radiology database mining. A particular focus is placed on the application of convolutional neural networks, with the theory supported by practical examples. ...
Deep Learning and Convolutional Neural Networks for Medical Image Computing: Precision Medicine, High Performance and Large-Scale Datasets
This book presents a detailed review of the state of the art in deep learning approaches for semantic object detection and segmentation in medical image computing, and large-scale radiology database mining. A particular focus is placed on the application of convolutional neural networks, with the theory supported by practical examples. Features: highlights how the use of deep neural networks can address new questions and protocols, as well as improve upon existing challenges in medical image computing; discusses the insightful research experience of Dr. Ronald M. Summers; presents a comprehensive review of the latest research and literature; describes a range of different methods that make use of deep learning for object or landmark detection tasks in 2D and 3D medical imaging; examines a varied selection of techniques for semantic segmentation using deep learning principles in medical imaging; introduces a novel approach to interleaved text and image deep mining on a large-scale radiology image database.
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145.950000 USD

Deep Learning and Convolutional Neural Networks for Medical Image Computing: Precision Medicine, High Performance and Large-Scale Datasets

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