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This thesis describes the authors' pioneering efforts in the conceptualization and implementation of combined platinum-based immuno-chemotherapeutics, which represent a significant paradigm shift from the conventional approach of directly targeting cancer. The work described has opened up a rich and largely unexplored area for platinum-based drug design, and ultimately paves the ...
Rethinking Platinum Anticancer Drug Design: Towards Targeted and Immuno-chemotherapeutic Approaches
This thesis describes the authors' pioneering efforts in the conceptualization and implementation of combined platinum-based immuno-chemotherapeutics, which represent a significant paradigm shift from the conventional approach of directly targeting cancer. The work described has opened up a rich and largely unexplored area for platinum-based drug design, and ultimately paves the way for superior immuno-chemotherapeutics with better clinical outcome for patients. Historically, the contribution of the immune system to chemotherapy outcomes has been neglected, as anticancer drugs were believed to be immunosuppressive. However, this has been challenged by contemporary evidence suggesting that many chemotherapeutics, including platinum-based agents, stimulate the innate and/or adaptive immune system and that these secret allies contribute tangibly to clinical outcomes. A multi-pronged immuno-chemotherapeutic approach not only shrinks tumors, but more importantly, reactivate dormant immune responses to malignancies, eliminating residual cancer cells.
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157.490000 USD

Rethinking Platinum Anticancer Drug Design: Towards Targeted and Immuno-chemotherapeutic Approaches

by Daniel Yuan Qiang Wong
Hardback
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Notable experts in the field of neuroimaging provide comprehensive overviews of advances in functional and structural aspects of both common and uncommon brain disorders. Functional imaging is evolving quickly but researchers and clinicians do not always have a strong understanding of the fundamental basis of the imaging techniques that they ...
The Neuroimaging of Brain Diseases: Structural and Functional Advances
Notable experts in the field of neuroimaging provide comprehensive overviews of advances in functional and structural aspects of both common and uncommon brain disorders. Functional imaging is evolving quickly but researchers and clinicians do not always have a strong understanding of the fundamental basis of the imaging techniques that they use. By focusing on both structure and function this book will provide a strong foundation for emerging developments in the field.
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188.990000 USD

The Neuroimaging of Brain Diseases: Structural and Functional Advances

Hardback
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With a focus on anatomy and sonoantomy, this beautifully illustrated updated edition captures the latest advances in the rapidly growing field of ultrasound-guided pain medicine and MSK procedures. This atlas is divided into seven sections that provide an overview and focus on interventional approaches and advancements. Authored by international experts, ...
Atlas of Ultrasound-Guided Procedures in Interventional Pain Management
With a focus on anatomy and sonoantomy, this beautifully illustrated updated edition captures the latest advances in the rapidly growing field of ultrasound-guided pain medicine and MSK procedures. This atlas is divided into seven sections that provide an overview and focus on interventional approaches and advancements. Authored by international experts, each clinical chapter features a maximal number of instructive illustrations and sonograms and provides a description of sonoanatomy, instructions on performing the procedure and how to confirm appropriate needle placement. This book will help encourage and stimulate physicians to master approaches in interventional MSK and pain management.
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261.450000 USD

Atlas of Ultrasound-Guided Procedures in Interventional Pain Management

Hardback
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This volume presents readers with the latest techniques to study nanoimaging and nanoprobing in application to a broad range of biological systems. The chapters in this book are divided into five parts, and cover topics such as imaging and probing of biomacromolecules including high-speed imaging and probing with AFM; probing ...
Nanoscale Imaging: Methods and Protocols
This volume presents readers with the latest techniques to study nanoimaging and nanoprobing in application to a broad range of biological systems. The chapters in this book are divided into five parts, and cover topics such as imaging and probing of biomacromolecules including high-speed imaging and probing with AFM; probing chromatin structure with magnetic tweezers; and fluorescence correlation spectroscopy on genomic DNA in living cells. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and through, Nanoscale Imaging: Methods and Protocols is a valuable resource for anyone interested in learning more about this developing and expanding field.
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293.990000 USD

Nanoscale Imaging: Methods and Protocols

Hardback
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Medicinal Chemistry teaches essential concepts by focusing on how the field is actually practiced, melding real-world research experience with basic principles and modern methods. Written by practicing medicinal chemists, this textbook is intended for advanced undergraduates and first-year graduate students in biology, chemistry, and biochemistry. Pre-medical or pre-pharmacy students and ...
Medicinal Chemistry
Medicinal Chemistry teaches essential concepts by focusing on how the field is actually practiced, melding real-world research experience with basic principles and modern methods. Written by practicing medicinal chemists, this textbook is intended for advanced undergraduates and first-year graduate students in biology, chemistry, and biochemistry. Pre-medical or pre-pharmacy students and professionals entering the drug discovery field will also find it a useful reference. Building on a foundation of synthetic organic chemistry and structural biology, the book interweaves therapeutics, case studies, historical context, and techniques for discovering, developing, and optimizing new drugs. Chapters are richly illustrated and include problems and annotated journal references with accompanying exercises and answers.
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105.79 USD

Medicinal Chemistry

by Donna M Huryn, Norma K Dunlap
Paperback
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This book focuses on the lobar anatomy of the breast and on the sick lobe concept - a novel theory of breast cancer development that is gaining ever wider acceptance - and explores their significance for innovative surgical treatment. Special attention is paid to the role of ductal echography, a ...
Lobar Approach to Breast Ultrasound
This book focuses on the lobar anatomy of the breast and on the sick lobe concept - a novel theory of breast cancer development that is gaining ever wider acceptance - and explores their significance for innovative surgical treatment. Special attention is paid to the role of ductal echography, a technique capable of clearly depicting the structures of cancer in relation to the structures of the sick lobe. Having established a sound theoretical and practical basis through detailed coverage and correlation of anatomy, pathology, and imaging appearances, the book goes on to describe a revolutionary surgical approach particularly suitable for the treatment of multifocal and multicentric breast carcinomas. Such tumors account for more than a third of all cases of breast carcinoma and are often treated by mastectomy. The proposed new breast-conserving technique yields excellent cosmetic results and entails a very low risk of recurrence. The book will appeal to a wide readership, including radiologists, surgeons, oncologists, pathologists, as well as residents.
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114.450000 USD

Lobar Approach to Breast Ultrasound

Hardback
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This book offers a comprehensive but straightforward, practical handbook on ultrasound (US)-guided nerve blocks. It presents the normal US anatomy of peripheral nerves, clinical aspects of nerve entrapment and different procedures / techniques for each block. Axial or peripheral chronic radicular pain can be particularly severe and debilitating for the ...
Ultrasound-Guided Peripheral Nerve Blocks
This book offers a comprehensive but straightforward, practical handbook on ultrasound (US)-guided nerve blocks. It presents the normal US anatomy of peripheral nerves, clinical aspects of nerve entrapment and different procedures / techniques for each block. Axial or peripheral chronic radicular pain can be particularly severe and debilitating for the patient. The aim of treatment is to provide medium-/ long-term pain relief, and consequently to restore function. The therapeutic nerve block, performed with a perineural injection of anaesthetic, steroid or painkiller, is generally used once conservative treatments have proven unsuccessful and is aimed to avoid surgical options. Ultrasound guidance, offering the direct and real-time visualization of the needle and adjacent relevant anatomic structures, significantly increases the accuracy and safety of nerve blocks reducing the risk of intraneural or intravascular injection and the potential damage to the surrounding structures, but also enhances the efficacy of the block itself, reducing its onset and drug doses. This practical volume addresses the needs of physicians dealing with pain management, e.g. anaesthesiologists, radiologists, orthopaedists and physiatrists, with various levels of experience, ranging from physicians in training to those who already perform peripheral nerve blocks with traditional techniques and who want to familiarize with US guided procedures.
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134.80 USD

Ultrasound-Guided Peripheral Nerve Blocks

Hardback
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The second edition of this important work provides a broad range of cardiac CT angiography (CCTA) cases covering normal anatomy, congenital coronary anomalies, coronary artery disease, percutaneous coronary intervention, postsurgical coronary revascularization, and extra-coronary abnormalities. It is designed to help practicing radiologists, cardiologists, and cardiothoracic surgeons understand the current issues ...
Coronary Artery CTA: A Case-Based Atlas
The second edition of this important work provides a broad range of cardiac CT angiography (CCTA) cases covering normal anatomy, congenital coronary anomalies, coronary artery disease, percutaneous coronary intervention, postsurgical coronary revascularization, and extra-coronary abnormalities. It is designed to help practicing radiologists, cardiologists, and cardiothoracic surgeons understand the current issues involved with clinical, interventional, and surgical management of coronary artery CTA. Each case consists of detailed CCTA images, a brief history, diagnosis, discussion, and pearls and pitfalls. This updated and expanded edition includes new chapters on principles of cardiac CT, patient preparation, cardiomyopathies, pediatric cardiac CT, cardiac CT in the emergency department, CT-FFR, and reporting cardiac CT.
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239.73 USD

Coronary Artery CTA: A Case-Based Atlas

Hardback
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Neuroimaging of Pain
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293.990000 USD

Neuroimaging of Pain

Hardback
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Host Defense Peptides and Their Potential as Therapeutic Agents
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209.990000 USD

Host Defense Peptides and Their Potential as Therapeutic Agents

Paperback
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Using Mass Spectrometry for Biochemical Studies on Enzymatic Domains from Polyketide Synthases
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146.990000 USD

Using Mass Spectrometry for Biochemical Studies on Enzymatic Domains from Polyketide Synthases

by Matthew Jenner
Paperback
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Herbal Medicine in Depression: Traditional Medicine to Innovative Drug Delivery
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262.490000 USD

Herbal Medicine in Depression: Traditional Medicine to Innovative Drug Delivery

Paperback
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Reviews of Physiology, Biochemistry and Pharmacology Vol. 170
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178.490000 USD

Reviews of Physiology, Biochemistry and Pharmacology Vol. 170

Paperback
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Acute Ischemic Stroke: Medical, Endovascular, and Surgical Techniques
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230.990000 USD

Acute Ischemic Stroke: Medical, Endovascular, and Surgical Techniques

Hardback
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In Vivo Fluorescence Imaging: Methods and Protocols
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178.490000 USD

In Vivo Fluorescence Imaging: Methods and Protocols

Paperback
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Vascular Lesions of the Orbit and Face: Imaging and Management
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125.990000 USD

Vascular Lesions of the Orbit and Face: Imaging and Management

Paperback
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Pharmaceutics: Development and Applications
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150.100000 USD

Pharmaceutics: Development and Applications

Hardback
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The Tree of Life: An Expose of Physical Regenesis on the Three-Fold Plane of Bodily, Chemical and Spiritual Operation (Classic Reprint)
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10.050000 USD

The Tree of Life: An Expose of Physical Regenesis on the Three-Fold Plane of Bodily, Chemical and Spiritual Operation (Classic Reprint)

by George W Carey
Paperback
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Diseases of the Central Airways: A Clinical Guide
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157.490000 USD

Diseases of the Central Airways: A Clinical Guide

Paperback
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This superb color atlas sets a new standard in neuroanatomy by presenting around 300 detailed thin-sectioned images of the human head, including the brain, with 0.1-mm intervals and a pixel size of 0.1 mm x 0.1 mm. A new reference system employed for this purpose is clearly explained, and structures ...
Cross-Sectional Atlas of the Human Head: With 0.1-mm pixel size color images
This superb color atlas sets a new standard in neuroanatomy by presenting around 300 detailed thin-sectioned images of the human head, including the brain, with 0.1-mm intervals and a pixel size of 0.1 mm x 0.1 mm. A new reference system employed for this purpose is clearly explained, and structures are fully annotated in the horizontal, coronal, and sagittal planes. Recent advances in 7T MRI and 7T TDI have considerably enhanced imaging of the human brain, thereby impacting on both neuroscience research and clinical practice. Moreover, the information gained from initiatives involving photography of thin slices of human cadavers, such as the Visible Human Projects, Visible Korean and Chinese Visible Human, has enriched knowledge of neuroanatomy and thereby facilitated the interpretation of such ultra-high-field resolution images. The exquisite images contained within this atlas will be invaluable in providing both researchers and clinicians with important new insights.
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167.990000 USD

Cross-Sectional Atlas of the Human Head: With 0.1-mm pixel size color images

by Jin Seo Park
Hardback
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This book is a collation of translational research outcomes in the area of life research, which was formerly used mainly for academic pursuits. The studies described focus on innovative interdisciplinary approaches to unraveling problems in life sciences and biomedicine using biodiversity exploration and green technology. The techniques and models presented ...
Perspectives in Translational Research in Life Sciences and Biomedicine: Translational Outcomes Research in Life Sciences and Translational Medicine, Volume 2
This book is a collation of translational research outcomes in the area of life research, which was formerly used mainly for academic pursuits. The studies described focus on innovative interdisciplinary approaches to unraveling problems in life sciences and biomedicine using biodiversity exploration and green technology. The techniques and models presented offer a ready reckoner for researchers in academic institutions and industry, and also provide valuable insights into fundamental research. The book discusses topics such as tissue engineering to create lineage-specific cells for tissue-specific regeneration; how combination cultures of commensalistic bacteria can help boost immunity; development of functional food from natural products from plant, animal, and microbial sources in the nutraceuticals domain; as well as synthesis and mechanisms in nanomedicine and nanoscaffolds in biomedicine. The studies and discourses described touch upon topics that explore biodiversity for the development of disease models, toxicity studies, developmental studies, and harvesting of bioactive compounds for alternative income generation and poverty alleviation, and as a result, bring about economic and ecologic sustainability. This multidimensional and multidisciplinary book focuses on tissue-specific targeting by nanodrugs, development of bioengineering formats for cell- based, nutraceutical-based, functional-food-based and antibody-based green therapy designed tackle multifaceted diseases and syndromes.
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188.990000 USD

Perspectives in Translational Research in Life Sciences and Biomedicine: Translational Outcomes Research in Life Sciences and Translational Medicine, Volume 2

by Ena Ray Banerjee
Hardback
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The field of materials science and technology has undergone revolutionary advances due to the development of novel analytical tools, functional materials, and multidisciplinary approaches to engineering. Additionally, theoretical predictions combined with increasingly improved models and computational capabilities are making impressive contributions to the progress of materials science and technology. In ...
Materials Science of DNA
The field of materials science and technology has undergone revolutionary advances due to the development of novel analytical tools, functional materials, and multidisciplinary approaches to engineering. Additionally, theoretical predictions combined with increasingly improved models and computational capabilities are making impressive contributions to the progress of materials science and technology. In particular, the materials science of DNA has emerged as a vital area of research and is expected to immensely broaden the horizon of material science and nanotechnology in this century. Materials Science of DNA highlights the most important subjects and perspectives in the field, with the aim of stimulating the interdisciplinary community and bringing this intensively interesting, emerging field of molecular-scale materials science to maturation. The editors have not only been involved in the research of materials science of DNA for the past decade, but also lead the series of International Biotronics Workshops supported by the US Air Force Research Laboratory. Biotechnology and DNA-based biopolymers are not only applicable for genomic sequencing and clinical diagnosis and treatment, but can also have a major impact on nonbiotech applications-such as electronics and photonics- opening up a whole new field for bioengineering. New concepts and insights gained from DNA research are expected to prove genuinely useful in a variety of devices in nano, micro, and macro dimensions in the future. Where silicon has been the building block of inorganic electronics and photonics, DNA holds promise to become the building block for organic electronics and photonics.
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66.53 USD

Materials Science of DNA

Paperback
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Insects have evolved very unique and interesting tactics using chemical signals to survive. Chemical ecology illustrates the working of the biological network by means of chemical analyses. Recent advances in analytical technology have opened the way to a better understanding of the more complicated and abyssal interactions of insects with ...
Chemical Ecology in Insects: Applications and Associations with Plants and Microbes
Insects have evolved very unique and interesting tactics using chemical signals to survive. Chemical ecology illustrates the working of the biological network by means of chemical analyses. Recent advances in analytical technology have opened the way to a better understanding of the more complicated and abyssal interactions of insects with other organisms including plants and microbes. This book covers recent research on insects and chemical communications and presents the current status about challenges faced by chemical ecologists for the management of pests in agriculture and human health.
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184.28 USD

Chemical Ecology in Insects: Applications and Associations with Plants and Microbes

Hardback
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Bioethanol and Natural Resources: Substrates, Chemistry and Engineered Systems provides a comprehensive review of feedstocks, physiochemical and biological pretreatments, molecular substrates, cellulolytic and ligninolytic enzymes, and advanced technologies for producing bioethanol. Although this book provides a review of first-generation bioethanol feedstocks, chemistry, and processes, there is an emphasis on second-generation ...
Bioethanol and Natural Resources: Substrates, Chemistry and Engineered Systems
Bioethanol and Natural Resources: Substrates, Chemistry and Engineered Systems provides a comprehensive review of feedstocks, physiochemical and biological pretreatments, molecular substrates, cellulolytic and ligninolytic enzymes, and advanced technologies for producing bioethanol. Although this book provides a review of first-generation bioethanol feedstocks, chemistry, and processes, there is an emphasis on second-generation cellulosic ethanol production. With rapid advances in biofuels technologies and the continued global dependency on unsustainable extraction of fossil fuels, this text is timely. Although it is intended to be used as a supplemental text for advanced undergraduate or graduate level courses, the book is accessible to a non-academic audience. This book provides a unique opportunity to understand bioethanol production from the basic concepts and processes to the most cutting-edge technologies under development.
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184.28 USD

Bioethanol and Natural Resources: Substrates, Chemistry and Engineered Systems

by Ruben Michael Ceballos
Hardback
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an impressive text that addresses a glaring gap in the teaching of physical chemistry, being specifically focused on biologically-relevant systems along with a practical focus.... the ample problems and tutorials throughout are much appreciated. -Tobin R. Sosnick, Professor and Chair of Biochemistry and Molecular Biology, University of Chicago Presents both ...
Biomolecular Thermodynamics: From Theory to Application
an impressive text that addresses a glaring gap in the teaching of physical chemistry, being specifically focused on biologically-relevant systems along with a practical focus.... the ample problems and tutorials throughout are much appreciated. -Tobin R. Sosnick, Professor and Chair of Biochemistry and Molecular Biology, University of Chicago Presents both the concepts and equations associated with statistical thermodynamics in a unique way that is at visual, intuitive, and rigorous. This approach will greatly benefit students at all levels. -Vijay S. Pande, Henry Dreyfus Professor of Chemistry, Stanford University a masterful tour de force.... Barrick's rigor and scholarship come through in every chapter. -Rohit V. Pappu, Edwin H. Murty Professor of Engineering, Washington University in St. Louis This book provides a comprehensive, contemporary introduction to developing a quantitative understanding of how biological macromolecules behave using classical and statistical thermodynamics. The author focuses on practical skills needed to apply the underlying equations in real life examples. The text develops mechanistic models, showing how they connect to thermodynamic observables, presenting simulations of thermodynamic behavior, and analyzing experimental data. The reader is presented with plenty of exercises and problems to facilitate hands-on learning through mathematical simulation. Douglas E. Barrick is a professor in the Department of Biophysics at Johns Hopkins University. He earned his Ph.D. in biochemistry from Stanford University, and a Ph.D. in biophysics and structural biology from the University of Oregon.
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122.85 USD

Biomolecular Thermodynamics: From Theory to Application

by Douglas Barrick
Paperback
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This fully updated and revised new edition provides a comprehensive, state-of-the art review of this field, and will serve as a valuable resource for clinicians, surgeons and researchers with an interest in prostate cancer. The book reviews new data about molecular characteristics of the disease, profiles the new grading system ...
Active Surveillance for Localized Prostate Cancer: A New Paradigm for Clinical Management
This fully updated and revised new edition provides a comprehensive, state-of-the art review of this field, and will serve as a valuable resource for clinicians, surgeons and researchers with an interest in prostate cancer. The book reviews new data about molecular characteristics of the disease, profiles the new grading system for prostate cancer introduced in 2015, and provides new perspectives about imaging of prostate cancer, as well as the role of targeted biopsies. The text summarizes the role of biomarkers and MRI in patient selection and management and details the world wide results of active surveillance. Specific chapters address communication and ethical issues, QOL outcomes, economic aspects, and psycho-social aspects of surveillance. The role of focal therapy for low risk disease is summarized, and the data supporting preventive interventions during surveillance reviewed. This text will serve as a very useful resource for physicians and researchers dealing with, and interested in this common malignancy, as it provides a concise yet comprehensive summary of the current status of the field that will help guide patient management and stimulate investigative efforts.
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157.490000 USD

Active Surveillance for Localized Prostate Cancer: A New Paradigm for Clinical Management

Hardback
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This book describes the fundamentals of three-dimensional (3D) printing, addresses the practical aspects of establishing a 3D printing service in a medical facility, and explains the enormous potential value of rendering images as 3D printed models capable of providing tactile feedback and tangible information on both anatomic and pathologic states. ...
3D Printing in Medicine: A Practical Guide for Medical Professionals
This book describes the fundamentals of three-dimensional (3D) printing, addresses the practical aspects of establishing a 3D printing service in a medical facility, and explains the enormous potential value of rendering images as 3D printed models capable of providing tactile feedback and tangible information on both anatomic and pathologic states. Individual chapters also focus on selected areas of applications for 3D printing, including musculoskeletal, craniomaxillofacial, cardiovascular, and neurosurgery applications. Challenges and opportunities related to training, materials and equipment, and guidelines are addressed, and the overall costs of a 3D printing lab and the balancing of these costs against clinical benefits are discussed. Radiologists, surgeons, and other physicians will find this book to be a rich source of information on the practicalities and expanding medical applications of 3D printing.
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114.450000 USD

3D Printing in Medicine: A Practical Guide for Medical Professionals

Mixed media product
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This book offers detailed guidance on the use of imaging in the context of bariatric surgery. After a summary of the types of surgical intervention, the role of imaging prior to and after surgery is explained, covering both the normal patient and the patient with complications. The most common pathologic ...
Imaging in Bariatric Surgery
This book offers detailed guidance on the use of imaging in the context of bariatric surgery. After a summary of the types of surgical intervention, the role of imaging prior to and after surgery is explained, covering both the normal patient and the patient with complications. The most common pathologic features that may be encountered in daily practice are identified and illustrated, and in addition the treatment of complications by means of interventional radiology and endoscopy is described. The authors are acknowledged international experts in the field, and the text is supported by surgical graphs and flow charts as well as numerous images. Overweight and obesity are very common problems estimated to affect nearly 30% of the world's population; nowadays, bariatric surgery is a safe and effective treatment option for people with severe obesity. The increasing incidence of bariatric surgery procedures makes it imperative that practitioners have a sound knowledge of the imaging appearances of postoperative anatomy and potential complications, and the book has been specifically designed to address the lack of knowledge in this area.
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94.490000 USD

Imaging in Bariatric Surgery

Hardback
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This book provides comprehensive information on Diagnostic Imaging for polytrauma patients. It provides extensive and detailed explanations of the semiotics of traumatic injuries, the correlation with the trauma's mechanism of action, and the meaning and appearance of prognostic indicators. The book begins with a discussion of the management of polytrauma ...
Diagnostic Imaging in Polytrauma Patients
This book provides comprehensive information on Diagnostic Imaging for polytrauma patients. It provides extensive and detailed explanations of the semiotics of traumatic injuries, the correlation with the trauma's mechanism of action, and the meaning and appearance of prognostic indicators. The book begins with a discussion of the management of polytrauma patients. Particular attention is given to the role of radiology in management, and each chapter includes an assessment of the radiological findings to be used as a clinical decision-making tool. Several typical cases are shown, supplemented by a wealth of images. The book offers a useful tool both for radiologists, who will find in it a valuable guide to correctly diagnosing traumatic injuries, and for clinicians, who will come to better understand the findings of the diagnostic tests performed on their patients
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219.450000 USD

Diagnostic Imaging in Polytrauma Patients

Mixed media product
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Lippincott Illustrated Reviews: Bioquimica
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81.90 USD

Lippincott Illustrated Reviews: Bioquimica

by Denise Ferrier
Paperback
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