The jihad began in El Reno, west of Oklahoma City. Something is killing America's livestock. A deadly plague is spreading in the nation's heartland, threatening to bring the country to its knees. British scientist Dr. Paul Caine is determined to find out the truth. As a suspect in the suspicious death of a Pakistani virologist during an international conference in San Francisco he is called upon by FBI Special Agent Angela Garcia to help trace the origin of the disease before it spreads out of control. But other interests are also involved. Who is the mysterious and sexy Chen Xiao Lin and why is she pursuing Caine? And what is the connection to Mainland Chinese separatists? Caine finds himself the unwitting key in a global conspiracy and he must overcome personal loyalties to uncover the origin of the plague and stop it before it is too late.