Provides a thorough, state-of-the-art review of the periplasm, the extracytoplasmic compartment found in gram-negative bacteria. * Details important aspects of the physiology of pathogenic microorganisms, a selection of current drug resistance strategies, and lipopolysaccharide biosynthesis. * Provides insights into the evolution of cellular compartments and their benefit to living organisms. * Discusses the basic biological functions of the periplasm and their physiological relevance, including protein transport, folding, and quality control; bioenergetics; solute transport; stress responses; cell division; and cell architecture. * Serves as a resource for medical practitioners and students of biology, microbiology, biochemistry, structural biology, and biotechnology This title is published by the American Society of Microbiology Press and distributed by Taylor and Francis in rest of world territories.