Spectral Tailoring for Boron Neutron Capture Therapy

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Since the first clinical trials on Boron Neutron Capture Therapy (BNCT) in the 1950s, BNCT research has been mainly focused on the treatment of (deep-seated) brain tumors, in particular, glioblastoma multiforme. Promising work to treat other cancers at other locations and even other diseases are in progress. Therefore, the chemists, medical doctors, physicists and biologists involved in BNCT are not only continuing to investigate and improve the (brain) clinical results, but are also investigating the new applications in BNCT. The work presented here is in the field of physics and deals, from three different viewpoints, with obtaining the optimal source neutron energy to optimize BNCT. The optimal source neutron energy is defined such as to obtain as many as possible (n,a)-absorptions due to 10B in the tumors and as low as possible total neutron dose in the healthy tissues and organs at risk.