An overview of the current understanding of how phagocytes recognize and respond to potentially pathogenic microbes. * Provides a current understanding of the role of the phagocyte in host defense. * Details the range of professional phagocyte cell lineages, including macrophages, PMNs, and dendritic cells. * Outlines the functions of and challenges to the professional phagocyte. * Improves our understanding of the cellular basis of antimicrobial responses. * Integrates cell and molecular biology with immunological perspectives. This title is published by the American Society of Microbiology Press and distributed by Taylor and Francis in rest of world territories.