Perinatal and Multigeneration Carcinogenesis

Paperback / softback
This study reviews and links together all aspects of research on problems connected with exposure of individuals to carcinogenic agents which may cause cancers in their offspring - or in subsequent generations - either by a transplacental effect from mother to fetus, or by a genetic effect on the germ cells before conception. It covers exposure analysis in animals, metabolism of carcinogens, molecular biological study of the role of oncogenes, multi-generation animal experiments and human epidemiological studies. Agents considered include polycyclic aromatic hydrocarbons, drugs such as diethylstilbestrol, and viruses and radiation, with particular focus on studies related to the atomic bombings of Hiroshima and Nagasaki. The text is based on the presentations of 30 international experts at a symposium held in Leningrad in June 1988.