Origin of Life: Chemical Approach

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Dedicated to the fond memory of two great pioneers of this science, Leslie E. Orgel and Stanley L. Miller, this compilation of reviews and original manuscripts provides an overview of the current state of the art, written by some of the eminent players in this creative domain of explorative chemistry . Since we are still far from finding a definitive answer to the most fundamental of questions in science, chemistry here is defined in its broadest sense. It is against this background that the contributions cover such a wide range of theories, including chemistry and selection, evolution of the pioneer organism, chemical aspects of synthetic biology, ribozyme catalysis of metabolism in the RNA world, intractable mixtures and the origin of life, the chemical etiology of nucleic acids, interstellar amino acids, and even the chemistry that preceded life's origin. The majority of the articles reproduced in this volume originally appeared in a special issue of Chemistry & Biodiversity under the title On Chemistry Leading to Life's Origin .