Molecular Pathology of Gastroenterological Cancer: Application to Clinical Practice

The past 20 years have seen remarkable progress in the research, diagnosis, and therapy of gastroenterological cancer. It has been shown that the development and progression of gastric and colon cancers require multiple alternations affecting DNA mismatch repair genes, oncogenes, and tumor-suppressor genes. Pathogenetic research has also demonstrated that the majority of gastrointestinal cancers express telomerase activity, with overexpression of telomerase RNA, providing powerful new tools for early detection. This volume brings together the most recent information on carcinogenesis, biology, molecular genetics, pathology, and molecular diagnosis of gastroenterological cancer, with contributions by renowned researchers from Japan and other parts of the world. Among the topics are experimental stomach carcinogenesis, molecular bases of human stomach carcinogenesis, critical determinants of human colon cancer metastasis, and telomere and telomerase in gastrointestinal cancer. Molecular Pathology of Gastroenterological Cancer is a vital source for oncologists, gastroenterologists, pathologists, epidemiologists, surgeons, and other clinicians.