This manual is a synthesis of current methodologies pertinent to the intensive hatchery culture of bivalve molluscs. It encompasses both the similarities and differences in approach in rearing clams, oysters and scallops in different climatic zones. All aspects of the culture process are described, together with basic considerations in choosing a site for hatchery development and in the design of a suitable facility. It also includes the post-hatchery handling of larvae in remote setting and also of spat in both land- and sea-based nurseries. This document is intended to assist both technicians entering the field as well as entrepreneurs researching investment opportunities in bivalve culture.